Regularized Surface and Point Landmarks Based Efficient Non-Rigid Medical Image Registration

Medical image registration is one of the fundamental tasks in medical image processing. It has various applications in field of image guided surgery (IGS) and computer assisted diagnosis (CAD). A set of non-linear methods have been already developed for inter-subject and intra-subject 3D medical image registration. However, efficient registration in terms of accuracy and speed is one of the most demanded of today surgical navigation (SN) systems. This paper is a result of a series of experiments which utilizes Fast Radial Basis Function (RBF) technique to register one or more medical images non-rigidly. Initially, a set of curves are extracted using a combined watershed and active contours algorithm and then tiled and converted to a regular surface using a global parameterization algorithm. It is shown that the registration accuracy improves when higher number of salient features (i.e. anatomical point landmarks and surfaces) are used and it also has no impact on the speed of the algorithm. The results show that the target registration error is less than 2 mm and has sub-second performance on intra-subject registration of MR image real datasets. It is observed that the Fast RBF algorithm is relatively insensitive to the increasing number of point landmarks used as compared with the competing feature based algorithms

Adversarial Deformation Regularization for Training Image Registration Neural Networks

We describe an adversarial learning approach to constrain convolutional neural network training for image registration, replacing heuristic smoothness measures of displacement fields often used in these tasks. Using minimally-invasive prostate cancer intervention as an example application, we demonstrate the feasibility of utilizing biomechanical simulations to regularize a weakly-supervised anatomical-label-driven registration network for aligning pre-procedural magnetic resonance (MR) and 3D intra-procedural transrectal ultrasound (TRUS) images. A discriminator network is optimized to distinguish the registration-predicted displacement fields from the motion data simulated by finite element analysis. During training, the registration network simultaneously aims to maximize similarity between anatomical labels that drives image alignment and to minimize an adversarial generator loss that measures divergence between the predicted- and simulated deformation. The end-to-end trained network enables efficient and fully-automated registration that only requires an MR and TRUS image pair as input, without anatomical labels or simulated data during inference. 108 pairs of labelled MR and TRUS images from 76 prostate cancer patients and 71,500 nonlinear finite-element simulations from 143 different patients were used for this study. We show that, with only gland segmentation as training labels, the proposed method can help predict physically plausible deformation without any other smoothness penalty. Based on cross-validation experiments using 834 pairs of independent validation landmarks, the proposed adversarial-regularized registration achieved a target registration error of 6.3 mm that is significantly lower than those from several other regularization methods.Comment: Accepted to MICCAI 201

Dense 3D Face Correspondence

We present an algorithm that automatically establishes dense correspondences between a large number of 3D faces. Starting from automatically detected sparse correspondences on the outer boundary of 3D faces, the algorithm triangulates existing correspondences and expands them iteratively by matching points of distinctive surface curvature along the triangle edges. After exhausting keypoint matches, further correspondences are established by generating evenly distributed points within triangles by evolving level set geodesic curves from the centroids of large triangles. A deformable model (K3DM) is constructed from the dense corresponded faces and an algorithm is proposed for morphing the K3DM to fit unseen faces. This algorithm iterates between rigid alignment of an unseen face followed by regularized morphing of the deformable model. We have extensively evaluated the proposed algorithms on synthetic data and real 3D faces from the FRGCv2, Bosphorus, BU3DFE and UND Ear databases using quantitative and qualitative benchmarks. Our algorithm achieved dense correspondences with a mean localisation error of 1.28mm on synthetic faces and detected $14$ anthropometric landmarks on unseen real faces from the FRGCv2 database with 3mm precision. Furthermore, our deformable model fitting algorithm achieved 98.5% face recognition accuracy on the FRGCv2 and 98.6% on Bosphorus database. Our dense model is also able to generalize to unseen datasets.Comment: 24 Pages, 12 Figures, 6 Tables and 3 Algorithm

Stratified decision forests for accurate anatomical landmark localization in cardiac images

Accurate localization of anatomical landmarks is an important step in medical imaging, as it provides useful prior information for subsequent image analysis and acquisition methods. It is particularly useful for initialization of automatic image analysis tools (e.g. segmentation and registration) and detection of scan planes for automated image acquisition. Landmark localization has been commonly performed using learning based approaches, such as classifier and/or regressor models. However, trained models may not generalize well in heterogeneous datasets when the images contain large differences due to size, pose and shape variations of organs. To learn more data-adaptive and patient specific models, we propose a novel stratification based training model, and demonstrate its use in a decision forest. The proposed approach does not require any additional training information compared to the standard model training procedure and can be easily integrated into any decision tree framework. The proposed method is evaluated on 1080 3D highresolution and 90 multi-stack 2D cardiac cine MR images. The experiments show that the proposed method achieves state-of-theart landmark localization accuracy and outperforms standard regression and classification based approaches. Additionally, the proposed method is used in a multi-atlas segmentation to create a fully automatic segmentation pipeline, and the results show that it achieves state-of-the-art segmentation accuracy

Scaled, patient-specific 3D vertebral model reconstruction based on 2D lateral fluoroscopy

Backgrounds: Accurate three-dimensional (3D) models of lumbar vertebrae are required for image-based 3D kinematics analysis. MRI or CT datasets are frequently used to derive 3D models but have the disadvantages that they are expensive, time-consuming or involving ionizing radiation (e.g., CT acquisition). An alternative method using 2D lateral fluoroscopy was developed. Materials and methods: A technique was developed to reconstruct a scaled 3D lumbar vertebral model from a single two-dimensional (2D) lateral fluoroscopic image and a statistical shape model of the lumbar vertebrae. Four cadaveric lumbar spine segments and two statistical shape models were used for testing. Reconstruction accuracy was determined by comparison of the surface models reconstructed from the single lateral fluoroscopic images to the ground truth data from 3D CT segmentation. For each case, two different surface-based registration techniques were used to recover the unknown scale factor, and the rigid transformation between the reconstructed surface model and the ground truth model before the differences between the two discrete surface models were computed. Results: Successful reconstruction of scaled surface models was achieved for all test lumbar vertebrae based on single lateral fluoroscopic images. The mean reconstruction error was between 0.7 and 1.6mm. Conclusions: A scaled, patient-specific surface model of the lumbar vertebra from a single lateral fluoroscopic image can be synthesized using the present approach. This new method for patient-specific 3D modeling has potential applications in spine kinematics analysis, surgical planning, and navigatio

DEFORM'06 - Proceedings of the Workshop on Image Registration in Deformable Environments

Preface These are the proceedings of DEFORM'06, the Workshop on Image Registration in Deformable Environments, associated to BMVC'06, the 17th British Machine Vision Conference, held in Edinburgh, UK, in September 2006. The goal of DEFORM'06 was to bring together people from different domains having interests in deformable image registration. In response to our Call for Papers, we received 17 submissions and selected 8 for oral presentation at the workshop. In addition to the regular papers, Andrew Fitzgibbon from Microsoft Research Cambridge gave an invited talk at the workshop. The conference website including online proceedings remains open, see http://comsee.univ-bpclermont.fr/events/DEFORM06. We would like to thank the BMVC'06 co-chairs, Mike Chantler, Manuel Trucco and especially Bob Fisher for is great help in the local arrangements, Andrew Fitzgibbon, and the Programme Committee members who provided insightful reviews of the submitted papers. Special thanks go to Marc Richetin, head of the CNRS Research Federation TIMS, which sponsored the workshop. August 2006 Adrien Bartoli Nassir Navab Vincent Lepeti

Constraint-Based Simulation for Non-Rigid Real-Time Registration

International audienceIn this paper we propose a method to address the problem of non-rigid registration in real-time. We use Lagrange multipliers and soft sliding constraints to combine data acquired from dynamic image sequence and a biomechanical model of the structure of interest. The biomechanical model plays a role of regulariza-tion to improve the robustness and the flexibility of the registration. We apply our method to a pre-operative 3D CT scan of a porcine liver that is registered to a sequence of 2D dynamic MRI slices during the respiratory motion. The finite element simulation provides a full 3D representation (including heterogeneities such as vessels, tumor,. . .) of the anatomical structure in real-time