362 research outputs found

    Reducing Streaking Artifacts in Quantitative Susceptibility Mapping

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    It is well known that reconstruction algorithms in quantitative susceptibility mapping often contain streaking artifacts. These are nondesirable objects that contaminate the image, and the possibility of removing or at least reducing them has a great practical interest. In [J. K. Choi, H. S. Park, S. Wang, Y. Wang, and J. K. Seo, SIAM J. Imaging Sci., 7 (2014), pp. 1669-1689], the cause of the artifacts is identified as propagation of singularities for a wave-type operator. In this work, we analyze such singularities using microlocal techniques and propose some strategies to reduce the artifacts.Peer reviewe

    Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications.

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    Quantitative susceptibility mapping (QSM) is a recently developed MRI technique for quantifying the spatial distribution of magnetic susceptibility within biological tissues. It first uses the frequency shift in the MRI signal to map the magnetic field profile within the tissue. The resulting field map is then used to determine the spatial distribution of the underlying magnetic susceptibility by solving an inverse problem. The solution is achieved by deconvolving the field map with a dipole field, under the assumption that the magnetic field is a result of the superposition of the dipole fields generated by all voxels and that each voxel has its unique magnetic susceptibility. QSM provides improved contrast to noise ratio for certain tissues and structures compared to its magnitude counterpart. More importantly, magnetic susceptibility is a direct reflection of the molecular composition and cellular architecture of the tissue. Consequently, by quantifying magnetic susceptibility, QSM is becoming a quantitative imaging approach for characterizing normal and pathological tissue properties. This article reviews the mechanism generating susceptibility contrast within tissues and some associated applications

    Hybrid data fidelity term approach for quantitative susceptibility mapping

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    PURPOSE: Susceptibility maps are usually derived from local magnetic field estimations by minimizing a functional composed of a data consistency term and a regularization term. The data-consistency term measures the difference between the desired solution and the measured data using typically the L2-norm. It has been proposed to replace this L2-norm with the L1-norm, due to its robustness to outliers and reduction of streaking artifacts arising from highly noisy or strongly perturbed regions. However, in regions with high SNR, the L1-norm yields a suboptimal denoising performance. In this work, we present a hybrid data fidelity approach that uses the L1-norm and subsequently the L2-norm to exploit the strengths of both norms. METHODS: We developed a hybrid data fidelity term approach for QSM (HD-QSM) based on linear susceptibility inversion methods, with total variation regularization. Each functional is solved with ADMM. The HD-QSM approach is a two-stage method that first finds a fast solution of the L1-norm functional and then uses this solution to initialize the L2-norm functional. In both norms we included spatially variable weights that improve the quality of the reconstructions. RESULTS: The HD-QSM approach produced good quantitative reconstructions in terms of structural definition, noise reduction, and avoiding streaking artifacts comparable with nonlinear methods, but with higher computational efficiency. Reconstructions performed with this method achieved first place at the lowest RMS error category in stage 1 of the 2019 QSM Reconstruction Challenge. CONCLUSIONS: The proposed method allows robust and accurate QSM reconstructions, obtaining superior performance to state-of-the-art methods

    Maximum Spherical Mean Value (mSMV) Filtering for Whole Brain Quantitative Susceptibility Mapping

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    To develop a tissue field filtering algorithm, called maximum Spherical Mean Value (mSMV), for reducing shadow artifacts in quantitative susceptibility mapping (QSM) of the brain without requiring brain tissue erosion.Residual background field is a major source of shadow artifacts in QSM. The mSMV algorithm filters large field values near the border, where the maximum value of the harmonic background field is located. The effectiveness of mSMV for artifact removal was evaluated by comparing with existing QSM algorithms in numerical brain simulation as well as using in vivo human data acquired from 11 healthy volunteers and 93 patients. Numerical simulation showed that mSMV reduces shadow artifacts and improves QSM accuracy. Better shadow reduction, as demonstrated by lower QSM variation in the gray matter and higher QSM image quality score, was also observed in healthy subjects and in patients with hemorrhages, stroke and multiple sclerosis. The mSMV algorithm allows QSM maps that are substantially equivalent to those obtained using SMV-filtered dipole inversion without eroding the volume of interest.Comment: 12 pages, 5 figure
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