Design of stable metabolic networks

In this work, we propose eigenvalue optimization combined with Lyapunov theory concepts to ensure stability of the Embden—Meyerhof–Parnas pathway, the pentosephosphate pathway, the phosphotransferase system and fermentation reactions of Escherichia coli. We address the design of a metabolic network for the maximization of different metabolite production rates. The first case study focuses on serine production, based on a model that consists of 18 differential equations corresponding to dynamic mass balances for extracellular glucose and intracellular metabolites, and thirty kinetic rate expressions. A second case study addresses the design problem to maximize ethanol production, based on a dynamic model that involves mass balancesfor 25 metabolites and 38 kinetic rate equations. The nonlinear optimization problem including stability constraints has been solved with reduced space Successive Quadratic Programming techniques. Numerical results provide useful insights on the stability properties of the studied kinetic models.Fil: Di Maggio, Jimena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Blanco, Anibal Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Bandoni, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Diaz Ricci, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Díaz, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentin

Optimal Control of Fuzzy Systems with Application to Rigid Body Attitude Control

In this chapter, the author presents a theoretical result on the optimal control of nonlinear dynamic systems. In this theoretical result, the author presents the optimal control problem for nonlinear dynamic systems and shows that this problem can be solved by utilizing the dynamic programming approach and the inverse optimal approach. The author employs the dynamic programming approach to derive the Hamilton-Jacobi-Bellman (H-J-B) equation associated with the optimal control problem for nonlinear dynamic systems. Then, the author presents an analytic way to solve the H-J-B equation with the help of the inverse optimal approach. Based on the theoretical result presented in this chapter, the author establishes an optimal control design for TS-type fuzzy systems that guarantees the global asymptotic stability of an equilibrium point and the optimality with respect to a cost function and provides good convergence rates of state trajectories to an equilibrium point. The author considers the three-axis attitude stabilization problem of a rigid body to illustrate the optimal control design method for TS-type fuzzy systems. The author designs the optimal three-axis attitude stabilizing control law for a rigid body based on this optimal control design method and analyzes its control performance by numerical simulations

Output-Feedback Control of Nonlinear Systems using Control Contraction Metrics and Convex Optimization

Control contraction metrics (CCMs) are a new approach to nonlinear control design based on contraction theory. The resulting design problems are expressed as pointwise linear matrix inequalities and are and well-suited to solution via convex optimization. In this paper, we extend the theory on CCMs by showing that a pair of "dual" observer and controller problems can be solved using pointwise linear matrix inequalities, and that when a solution exists a separation principle holds. That is, a stabilizing output-feedback controller can be found. The procedure is demonstrated using a benchmark problem of nonlinear control: the Moore-Greitzer jet engine compressor model.Comment: Conference submissio