Analysis of Clickstream Data

This thesis is concerned with providing further statistical development in the area of web usage analysis to explore web browsing behaviour patterns. We received two data sources: web log files and operational data files for the websites, which contained information on online purchases. There are many research question regarding web browsing behaviour. Specifically, we focused on the depth-of-visit metric and implemented an exploratory analysis of this feature using clickstream data. Due to the large volume of data available in this context, we chose to present effect size measures along with all statistical analysis of data. We introduced two new robust measures of effect size for two-sample comparison studies for Non-normal situations, specifically where the difference of two populations is due to the shape parameter. The proposed effect sizes perform adequately for non-normal data, as well as when two distributions differ from shape parameters. We will focus on conversion analysis, to investigate the causal relationship between the general clickstream information and online purchasing using a logistic regression approach. The aim is to find a classifier by assigning the probability of the event of online shopping in an e-commerce website. We also develop the application of a mixture of hidden Markov models (MixHMM) to model web browsing behaviour using sequences of web pages viewed by users of an e-commerce website. The mixture of hidden Markov model will be performed in the Bayesian context using Gibbs sampling. We address the slow mixing problem of using Gibbs sampling in high dimensional models, and use the over-relaxed Gibbs sampling, as well as forward-backward EM algorithm to obtain an adequate sample of the posterior distributions of the parameters. The MixHMM provides an advantage of clustering users based on their browsing behaviour, and also gives an automatic classification of web pages based on the probability of observing web page by visitors in the website

Analysing functional genomics data using novel ensemble, consensus and data fusion techniques

Motivation: A rapid technological development in the biosciences and in computer science in the last decade has enabled the analysis of high-dimensional biological datasets on standard desktop computers. However, in spite of these technical advances, common properties of the new high-throughput experimental data, like small sample sizes in relation to the number of features, high noise levels and outliers, also pose novel challenges. Ensemble and consensus machine learning techniques and data integration methods can alleviate these issues, but often provide overly complex models which lack generalization capability and interpretability. The goal of this thesis was therefore to develop new approaches to combine algorithms and large-scale biological datasets, including novel approaches to integrate analysis types from different domains (e.g. statistics, topological network analysis, machine learning and text mining), to exploit their synergies in a manner that provides compact and interpretable models for inferring new biological knowledge. Main results: The main contributions of the doctoral project are new ensemble, consensus and cross-domain bioinformatics algorithms, and new analysis pipelines combining these techniques within a general framework. This framework is designed to enable the integrative analysis of both large- scale gene and protein expression data (including the tools ArrayMining, Top-scoring pathway pairs and RNAnalyze) and general gene and protein sets (including the tools TopoGSA , EnrichNet and PathExpand), by combining algorithms for different statistical learning tasks (feature selection, classification and clustering) in a modular fashion. Ensemble and consensus analysis techniques employed within the modules are redesigned such that the compactness and interpretability of the resulting models is optimized in addition to the predictive accuracy and robustness. The framework was applied to real-word biomedical problems, with a focus on cancer biology, providing the following main results: (1) The identification of a novel tumour marker gene in collaboration with the Nottingham Queens Medical Centre, facilitating the distinction between two clinically important breast cancer subtypes (framework tool: ArrayMining) (2) The prediction of novel candidate disease genes for Alzheimer’s disease and pancreatic cancer using an integrative analysis of cellular pathway definitions and protein interaction data (framework tool: PathExpand, collaboration with the Spanish National Cancer Centre) (3) The prioritization of associations between disease-related processes and other cellular pathways using a new rule-based classification method integrating gene expression data and pathway definitions (framework tool: Top-scoring pathway pairs) (4) The discovery of topological similarities between differentially expressed genes in cancers and cellular pathway definitions mapped to a molecular interaction network (framework tool: TopoGSA, collaboration with the Spanish National Cancer Centre) In summary, the framework combines the synergies of multiple cross-domain analysis techniques within a single easy-to-use software and has provided new biological insights in a wide variety of practical settings

Industrial Symbiosis Recommender Systems

For a long time, humanity has lived upon the paradigm that the amounts of natural resources are unlimited and that the environment has ample regenerative capacity. However, the notion to shift towards sustainability has resulted in a worldwide adoption of policies addressing resource efficiency and preservation of natural resources.One of the key environmental and economic sustainable operations that is currently promoted and enacted in the European Union policy is Industrial Symbiosis. In industrial symbiosis, firms aim to reduce the total material and energy footprint by circulating traditional secondary production process outputs of firms to become part of an input for the production process of other firms.This thesis directs attention to the design considerations for recommender systems in the highly dynamic domain of industrial symbiosis. Recommender systems are a promising technology that may facilitate in multiple facets of the industrial symbiosis creation as they reduce the complexity of decision making. This typical strength of recommender systems has been responsible for improved sales and a higher return of investments. That provides the prospect for industrial symbiosis recommenders to increase the number of synergistic transactions that reduce the total environmental impact of the process industry in particular

Asian Yearbook of International Law, Volume 23 (2017)

The Yearbook aims to promote research, studies and writings in the field of international law in Asia, as well as to provide an intellectual platform for the discussion and dissemination of Asian views and practices on contemporary international legal issues. ; Readership: All interested in International Law and Asian Law