PROCESS AWARE ANALOG-CENTRIC SINGLE LEAD ECG ACQUISITION AND CLASSIFICATION CMOS FRONTEND

The primary objective of this research work is the development of a low power single-lead ECG analog front-end (AFE) architecture which includes acquisition, digitization, process aware efficient gain and frequency control mechanism and a low complexity classifier for the detecting asystole, extreme bardycardia and tachycardia. Recent research on ECG recording systems focuses on the design of a compact single-lead wearable/portable devices with ultra-low-power consumption and in-built hardware for diagnosis and prognosis. Since, the amplitude of the ECG signal varies from hundreds of µV to a few mV, and has a bandwidth of DC to 250 Hz, conventional front-ends use an instrument amplifier followed by a programmable gain amplifier (PGA) to amplify the input ECG signal appropriately. This work presents an mixed signal ECG fronted with an ultra-low power two-stage capacitive-coupled signal conditioning circuit (or an AFE), providing programmable amplification along with tunable 2nd order high pass and lowpass filter characteristics. In the contemporary state-of-the-art ECG recording systems, the gain of the amplifier is controlled by external digital control pins which are in turn dynamically controlled through a DSP. Therefore, an efficient automatic gain control mechanism with minimal area overhead and consuming power in the order of nano watts only. The AGC turns the subsequent ADC on only after output of the PGA (or input of the ADC) reaches a level for which the ADC achieves maximum signal-to-noise-ratio (SNR), hence saving considerable startup power and avoiding the use of DSP. Further, in any practical filter design, the low pass cut-off frequency is prone to deviate from its nominal value across process and temperature variations. Therefore, post-fabrication calibration is essential, before the signal is fed to an ADC, to minimize this deviation, prevent signal degradation due to aliasing of higher frequencies into the bandwidth for classification of ECG signals, to switch to low resolution processing, hence saving power and enhances battery lifetime. Another short-coming noticed in the literature published so far is that the classification algorithm is implemented in digital domain, which turns out to be a power hungry approach. Moreover, Although analog domain implementations of QRS complexes detection schemes have been reported, they employ an external micro-controller to determine the threshold voltage. In this regard, finally a power-efficient low complexity CMOS fully analog classifier architecture and a heart rate estimator is added to the above scheme. It reduces the overall system power consumption by reducing the computational burden on the DSP. The complete proposed scheme consists of (i) an ultra-low power QRS complex detection circuit using an autonomous dynamic threshold voltage, hence discarding the need of any external microcontroller/DSP and calibration (ii) a power efficient analog classifier for the detection of three critical alarm types viz. asystole, extreme bradycardia and tachycardia. Additionally, a heart rate estimator that provides the number of QRS complexes within a period of one minute for cardiac rhythm (CR) and heart rate variability (HRV) analysis. The complete proposed architecture is implemented in UMC 0.18 µm CMOS technology with 1.8 V supply. The functionality of each of the individual blocks are successfully validated using postextraction process corner simulations and through real ECG test signals taken from the PhysioNet database. The capacitive feedback amplifier, Σ∆ ADC, AGC and the AFT are fabricated, and the measurement results are discussed here. The analog classification scheme is successfully validated using embed NXP LPC1768 board, discrete peak detector prototype and FPGA software interfac

Optically Induced Nanostructures

Nanostructuring of materials is a task at the heart of many modern disciplines in mechanical engineering, as well as optics, electronics, and the life sciences. This book includes an introduction to the relevant nonlinear optical processes associated with very short laser pulses for the generation of structures far below the classical optical diffraction limit of about 200 nanometers as well as coverage of state-of-the-art technical and biomedical applications. These applications include silicon and glass wafer processing, production of nanowires, laser transfection and cell reprogramming, optical cleaning, surface treatments of implants, nanowires, 3D nanoprinting, STED lithography, friction modification, and integrated optics. The book highlights also the use of modern femtosecond laser microscopes and nanoscopes as novel nanoprocessing tools

Wireless Techniques for Body-Centric Cooperative Communications

Body-centric and cooperative communications are new trends in telecommunications field. Being concerned with human behaviour, body-centric communication networks, also known as Wireless Body Area Networks (WBANs), are suitable for a wide variety of applications. The advances in the miniaturisation of embedded devices to be placed on or around the body, foster the diffusion of these systems, where the human body is the key element defining communication characteristics. Cooperative communications paradigm, on the other hand, is one of the emerging technologies that promises significantly higher reliability and spectral efficiency in wireless networks. This thesis investigates possible applications of the cooperative communication paradigm to body-centric networks and, more generally, to Wireless Sensor Networks (WSNs). Firstly, communication protocols for WBANs are in the spotlight. Performance achieved by different approaches is evaluated and compared through experimentation providing guidelines for choosing appropriate protocol and setting protocol parameters to meet application requirements. Secondly, a cooperative Multiple Input Multiple Output (MIMO) scheme for WBANs is presented. The scheme, named B-MIMO, exploits the natural heterogeneity of the WBAN propagation channel to improve energy efficiency of the system. Finally, a WSN scenario is considered, where sensor nodes cooperate to establish a massive MIMO-like system. The analysis and subsequent optimisation show the advantages of cooperation in terms of energy efficiency and provide insights on how many nodes should be deployed in such a scenario

Integrated Programmable-Array accelerator to design heterogeneous ultra-low power manycore architectures

There is an ever-increasing demand for energy efficiency (EE) in rapidly evolving Internet-of-Things end nodes. This pushes researchers and engineers to develop solutions that provide both Application-Specific Integrated Circuit-like EE and Field-Programmable Gate Array-like flexibility. One such solution is Coarse Grain Reconfigurable Array (CGRA). Over the past decades, CGRAs have evolved and are competing to become mainstream hardware accelerators, especially for accelerating Digital Signal Processing (DSP) applications. Due to the over-specialization of computing architectures, the focus is shifting towards fitting an extensive data representation range into fewer bits, e.g., a 32-bit space can represent a more extensive data range with floating-point (FP) representation than an integer representation. Computation using FP representation requires numerous encodings and leads to complex circuits for the FP operators, decreasing the EE of the entire system. This thesis presents the design of an EE ultra-low-power CGRA with native support for FP computation by leveraging an emerging paradigm of approximate computing called transprecision computing. We also present the contributions in the compilation toolchain and system-level integration of CGRA in a System-on-Chip, to envision the proposed CGRA as an EE hardware accelerator. Finally, an extensive set of experiments using real-world algorithms employed in near-sensor processing applications are performed, and results are compared with state-of-the-art (SoA) architectures. It is empirically shown that our proposed CGRA provides better results w.r.t. SoA architectures in terms of power, performance, and area

Driving the Network-on-Chip Revolution to Remove the Interconnect Bottleneck in Nanoscale Multi-Processor Systems-on-Chip

The sustained demand for faster, more powerful chips has been met by the availability of chip manufacturing processes allowing for the integration of increasing numbers of computation units onto a single die. The resulting outcome, especially in the embedded domain, has often been called SYSTEM-ON-CHIP (SoC) or MULTI-PROCESSOR SYSTEM-ON-CHIP (MP-SoC). MPSoC design brings to the foreground a large number of challenges, one of the most prominent of which is the design of the chip interconnection. With a number of on-chip blocks presently ranging in the tens, and quickly approaching the hundreds, the novel issue of how to best provide on-chip communication resources is clearly felt. NETWORKS-ON-CHIPS (NoCs) are the most comprehensive and scalable answer to this design concern. By bringing large-scale networking concepts to the on-chip domain, they guarantee a structured answer to present and future communication requirements. The point-to-point connection and packet switching paradigms they involve are also of great help in minimizing wiring overhead and physical routing issues. However, as with any technology of recent inception, NoC design is still an evolving discipline. Several main areas of interest require deep investigation for NoCs to become viable solutions: • The design of the NoC architecture needs to strike the best tradeoff among performance, features and the tight area and power constraints of the onchip domain. • Simulation and verification infrastructure must be put in place to explore, validate and optimize the NoC performance. • NoCs offer a huge design space, thanks to their extreme customizability in terms of topology and architectural parameters. Design tools are needed to prune this space and pick the best solutions. • Even more so given their global, distributed nature, it is essential to evaluate the physical implementation of NoCs to evaluate their suitability for next-generation designs and their area and power costs. This dissertation performs a design space exploration of network-on-chip architectures, in order to point-out the trade-offs associated with the design of each individual network building blocks and with the design of network topology overall. The design space exploration is preceded by a comparative analysis of state-of-the-art interconnect fabrics with themselves and with early networkon- chip prototypes. The ultimate objective is to point out the key advantages that NoC realizations provide with respect to state-of-the-art communication infrastructures and to point out the challenges that lie ahead in order to make this new interconnect technology come true. Among these latter, technologyrelated challenges are emerging that call for dedicated design techniques at all levels of the design hierarchy. In particular, leakage power dissipation, containment of process variations and of their effects. The achievement of the above objectives was enabled by means of a NoC simulation environment for cycleaccurate modelling and simulation and by means of a back-end facility for the study of NoC physical implementation effects. Overall, all the results provided by this work have been validated on actual silicon layout

1996 Laboratory directed research and development annual report

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms

Solid State Circuits Technologies

The evolution of solid-state circuit technology has a long history within a relatively short period of time. This technology has lead to the modern information society that connects us and tools, a large market, and many types of products and applications. The solid-state circuit technology continuously evolves via breakthroughs and improvements every year. This book is devoted to review and present novel approaches for some of the main issues involved in this exciting and vigorous technology. The book is composed of 22 chapters, written by authors coming from 30 different institutions located in 12 different countries throughout the Americas, Asia and Europe. Thus, reflecting the wide international contribution to the book. The broad range of subjects presented in the book offers a general overview of the main issues in modern solid-state circuit technology. Furthermore, the book offers an in depth analysis on specific subjects for specialists. We believe the book is of great scientific and educational value for many readers. I am profoundly indebted to the support provided by all of those involved in the work. First and foremost I would like to acknowledge and thank the authors who worked hard and generously agreed to share their results and knowledge. Second I would like to express my gratitude to the Intech team that invited me to edit the book and give me their full support and a fruitful experience while working together to combine this book

Silicon Nanodevices

This book is a collection of scientific articles which brings research in Si nanodevices, device processing, and materials. The content is oriented to optoelectronics with a core in electronics and photonics. The issue of current technology developments in the nanodevices towards 3D integration and an emerging of the electronics and photonics as an ultimate goal in nanotechnology in the future is presented. The book contains a few review articles to update the knowledge in Si-based devices and followed by processing of advanced nano-scale transistors. Furthermore, material growth and manufacturing of several types of devices are presented. The subjects are carefully chosen to critically cover the scientific issues for scientists and doctoral students

Applications

Volume 3 describes how resource-aware machine learning methods and techniques are used to successfully solve real-world problems. The book provides numerous specific application examples: in health and medicine for risk modelling, diagnosis, and treatment selection for diseases in electronics, steel production and milling for quality control during manufacturing processes in traffic, logistics for smart cities and for mobile communications