A review of physics-based models in prognostics: application to gears and bearings of rotating machinery

Health condition monitoring for rotating machinery has been developed for many years due to its potential to reduce the cost of the maintenance operations and increase availability. Covering aspects include sensors, signal processing, health assessment and decision-making. This article focuses on prognostics based on physics-based models. While the majority of the research in health condition monitoring focuses on data-driven techniques, physics-based techniques are particularly important if accuracy is a critical factor and testing is restricted. Moreover, the benefits of both approaches can be combined when data-driven and physics-based techniques are integrated. This article reviews the concept of physics-based models for prognostics. An overview of common failure modes of rotating machinery is provided along with the most relevant degradation mechanisms. The models available to represent these degradation mechanisms and their application for prognostics are discussed. Models that have not been applied to health condition monitoring, for example, wear due to metal–metal contact in hydrodynamic bearings, are also included due to its potential for health condition monitoring. The main contribution of this article is the identification of potential physics-based models for prognostics in rotating machinery

Physics-based analysis of Affymetrix microarray data

We analyze publicly available data on Affymetrix microarrays spike-in experiments on the human HGU133 chipset in which sequences are added in solution at known concentrations. The spike-in set contains sequences of bacterial, human and artificial origin. Our analysis is based on a recently introduced molecular-based model [E. Carlon and T. Heim, Physica A 362, 433 (2006)] which takes into account both probe-target hybridization and target-target partial hybridization in solution. The hybridization free energies are obtained from the nearest-neighbor model with experimentally determined parameters. The molecular-based model suggests a rescaling that should result in a "collapse" of the data at different concentrations into a single universal curve. We indeed find such a collapse, with the same parameters as obtained before for the older HGU95 chip set. The quality of the collapse varies according to the probe set considered. Artificial sequences, chosen by Affymetrix to be as different as possible from any other human genome sequence, generally show a much better collapse and thus a better agreement with the model than all other sequences. This suggests that the observed deviations from the predicted collapse are related to the choice of probes or have a biological origin, rather than being a problem with the proposed model.Comment: 11 pages, 10 figure

Physics-based visual characterization of molecular interaction forces

Molecular simulations are used in many areas of biotechnology, such as drug design and enzyme engineering. Despite the development of automatic computational protocols, analysis of molecular interactions is still a major aspect where human comprehension and intuition are key to accelerate, analyze, and propose modifications to the molecule of interest. Most visualization algorithms help the users by providing an accurate depiction of the spatial arrangement: the atoms involved in inter-molecular contacts. There are few tools that provide visual information on the forces governing molecular docking. However, these tools, commonly restricted to close interaction between atoms, do not consider whole simulation paths, long-range distances and, importantly, do not provide visual cues for a quick and intuitive comprehension of the energy functions (modeling intermolecular interactions) involved. In this paper, we propose visualizations designed to enable the characterization of interaction forces by taking into account several relevant variables such as molecule-ligand distance and the energy function, which is essential to understand binding affinities. We put emphasis on mapping molecular docking paths obtained from Molecular Dynamics or Monte Carlo simulations, and provide time-dependent visualizations for different energy components and particle resolutions: atoms, groups or residues. The presented visualizations have the potential to support domain experts in a more efficient drug or enzyme design process.Peer ReviewedPostprint (author's final draft

Interacting with Acoustic Simulation and Fabrication

Incorporating accurate physics-based simulation into interactive design tools is challenging. However, adding the physics accurately becomes crucial to several emerging technologies. For example, in virtual/augmented reality (VR/AR) videos, the faithful reproduction of surrounding audios is required to bring the immersion to the next level. Similarly, as personal fabrication is made possible with accessible 3D printers, more intuitive tools that respect the physical constraints can help artists to prototype designs. One main hurdle is the sheer amount of computation complexity to accurately reproduce the real-world phenomena through physics-based simulation. In my thesis research, I develop interactive tools that implement efficient physics-based simulation algorithms for automatic optimization and intuitive user interaction.Comment: ACM UIST 2017 Doctoral Symposiu

Major challenges in prognostics: study on benchmarking prognostic datasets

Even though prognostics has been defined to be one of the most difficult tasks in Condition Based Maintenance (CBM), many studies have reported promising results in recent years. The nature of the prognostics problem is different from diagnostics with its own challenges. There exist two major approaches to prognostics: data-driven and physics-based models. This paper aims to present the major challenges in both of these approaches by examining a number of published datasets for their suitability for analysis. Data-driven methods require sufficient samples that were run until failure whereas physics-based methods need physics of failure progression