Thermal ablation with configurable shapes: a comprehensive, automated model for bespoke tumor treatment.

BACKGROUND Malignant tumors routinely present with irregular shapes and complex configurations. The lack of customization to individual tumor shapes and standardization of procedures limits the success and application of thermal ablation. METHODS We introduced an automated treatment model consisting of (i) trajectory and ablation profile planning, (ii) ablation probe insertion, (iii) dynamic energy delivery (including robotically driven control of the energy source power and location over time, according to a treatment plan bespoke to the tumor shape), and (iv) quantitative ablation margin verification. We used a microwave ablation system and a liver phantom (acrylamide polymer with a thermochromic ink) to mimic coagulation and measure the ablation volume. We estimated the ablation width as a function of power and velocity following a probabilistic model. Four representative shapes of liver tumors < 5 cm were selected from two publicly available databases. The ablated specimens were cut along the ablation probe axis and photographed. The shape of the ablated volume was extracted using a color-based segmentation method. RESULTS The uncertainty (standard deviation) of the ablation width increased with increasing power by ± 0.03 mm (95% credible interval [0.02, 0.043]) per watt increase in power and by ± 0.85 mm (95% credible interval [0, 2.5]) per mm/s increase in velocity. Continuous ablation along a straight-line trajectory resulted in elongated rotationally symmetric ablation shapes. Simultaneous regulation of the power and/or translation velocity allowed to modulate the ablation width at specific locations. CONCLUSIONS This study offers the proof-of-principle of the dynamic energy delivery system using ablation shapes from clinical cases of malignant liver tumors. RELEVANCE STATEMENT The proposed automated treatment model could favor the customization and standardization of thermal ablation for complex tumor shapes. KEY POINTS • Current thermal ablation systems are limited to ellipsoidal or spherical shapes. • Dynamic energy delivery produces elongated rotationally symmetric ablation shapes with varying widths. • For complex tumor shapes, multiple customized ablation shapes could be combined

Reliable data delivery in low energy ad hoc sensor networks

Reliable delivery of data is a classical design goal for reliability-oriented collection routing protocols for ad hoc wireless sensor networks (WSNs). Guaranteed packet delivery performance can be ensured by careful selection of error free links, quick recovery from packet losses, and avoidance of overloaded relay sensor nodes. Due to limited resources of individual senor nodes, there is usually a trade-off between energy spending for packets transmissions and the appropriate level of reliability. Since link failures and packet losses are unavoidable, sensor networks may tolerate a certain level of reliability without significantly affecting packets delivery performance and data aggregation accuracy in favor of efficient energy consumption. However a certain degree of reliability is needed, especially when hop count increases between source sensor nodes and the base station as a single lost packet may result in loss of a large amount of aggregated data along longer hops. An effective solution is to jointly make a trade-off between energy, reliability, cost, and agility while improving packet delivery, maintaining low packet error ratio, minimizing unnecessary packets transmissions, and adaptively reducing control traffic in favor of high success reception ratios of representative data packets. Based on this approach, the proposed routing protocol can achieve moderate energy consumption and high packet delivery ratio even with high link failure rates. The proposed routing protocol was experimentally investigated on a testbed of Crossbow's TelosB motes and proven to be more robust and energy efficient than the current implementation of TinyOS2.x MultihopLQI

JTP: An Energy-conscious Transport Protocol for Wireless Ad Hoc Networks

Within a recently developed low-power ad hoc network system, we present a transport protocol (JTP) whose goal is to reduce power consumption without trading off delivery requirements of applications. JTP has the following features: it is lightweight whereby end-nodes control in-network actions by encoding delivery requirements in packet headers; JTP enables applications to specify a range of reliability requirements, thus allocating the right energy budget to packets; JTP minimizes feedback control traffic from the destination by varying its frequency based on delivery requirements and stability of the network; JTP minimizes energy consumption by implementing in-network caching and increasing the chances that data retransmission requests from destinations "hit" these caches, thus avoiding costly source retransmissions; and JTP fairly allocates bandwidth among flows by backing off the sending rate of a source to account for in-network retransmissions on its behalf. Analysis and extensive simulations demonstrate the energy gains of JTP over one-size-fits-all transport protocols.Defense Advanced Research Projects Agency (AFRL FA8750-06-C-0199

Scalability analysis of large-scale LoRaWAN networks in ns-3

As LoRaWAN networks are actively being deployed in the field, it is important to comprehend the limitations of this Low Power Wide Area Network technology. Previous work has raised questions in terms of the scalability and capacity of LoRaWAN networks as the number of end devices grows to hundreds or thousands per gateway. Some works have modeled LoRaWAN networks as pure ALOHA networks, which fails to capture important characteristics such as the capture effect and the effects of interference. Other works provide a more comprehensive model by relying on empirical and stochastic techniques. This work uses a different approach where a LoRa error model is constructed from extensive complex baseband bit error rate simulations and used as an interference model. The error model is combined with the LoRaWAN MAC protocol in an ns-3 module that enables to study multi channel, multi spreading factor, multi gateway, bi-directional LoRaWAN networks with thousands of end devices. Using the lorawan ns-3 module, a scalability analysis of LoRaWAN shows the detrimental impact of downstream traffic on the delivery ratio of confirmed upstream traffic. The analysis shows that increasing gateway density can ameliorate but not eliminate this effect, as stringent duty cycle requirements for gateways continue to limit downstream opportunities.Comment: 12 pages, submitted to the IEEE Internet of Things Journa

Method Of Applying Acoustic Energy Effective To Alter Transport Or Cell Viability

A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with devices for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cells or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.Georgia Tech Research Corporatio

Traffic eavesdropping based scheme to deliver time-sensitive data in sensor networks

Due to the broadcast nature of wireless channels, neighbouring sensor nodes may overhear packets transmissions from each other even if they are not the intended recipients of these transmissions. This redundant packet reception leads to unnecessary expenditure of battery energy of the recipients. Particularly in highly dense sensor networks, overhearing or eavesdropping overheads can constitute a significant fraction of the total energy consumption. Since overhearing of wireless traffic is unavoidable and sometimes essential, a new distributed energy efficient scheme is proposed in this paper. This new scheme exploits the inevitable overhearing effect as an effective approach in order to collect the required information to perform energy efficient delivery for data aggregation. Based on this approach, the proposed scheme achieves moderate energy consumption and high packet delivery rate notwithstanding the occurrence of high link failure rates. The performance of the proposed scheme is experimentally investigated a testbed of TelosB motes in addition to ns-2 simulations to validate the performed experiments on large-scale network