1,976,559 research outputs found

    Up or Down? How Culture and Color Affect Judgments

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    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.In the Mainland China stock market, an upmarket is represented by the color red, whereas a downmarket is represented by the color green. Elsewhere, including the Chinese Hong Kong stock market, the color representations are the opposite. Three studies were conducted to examine the red-up–green-down effect for Mainland Chinese as well as the green-up–red-down effect for Hong Kong people. Study 1 showed that Mainland Chinese tended to predict greater economic growth (study 1a) and higher growth in consumption trends (study 1b) when the experimental materials were presented in red than in green, whereas Hong Kong participants exhibited the opposite tendencies. Study 2 found that Mainland Chinese implicitly associated red and green with up and down, respectively; Hong Kong people, however, implicitly associated green and red with up and down, respectively. Study 3 further indicated that Mainland Chinese were more likely to predict good outcomes when scenarios were presented in red, whereas Hong Kong participants were more likely to predict good outcomes when scenarios were presented in green. These findings suggest that culturally specific environment cues could influence human prediction and judgment. Implications for judgment generally are discussed

    Early warning: a people-centred approach to early warning systems and the 'last mile'

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    The people-centred approach to early warning focuses on how communities can understand threats and avoid them. Disasters are partly caused by external hazards, but they also stem simply from vulnerability: people being in the wrong place without adequate protection. Perhaps the most well-known risk assessment method of recent years is the “vulnerability and capacity assessment”, developed by the Red Cross Red Crescent. There is a consensus that information must extend to communities so as to facilitate their adoption of protective actions. The linking of early warning and early action with development aspirations is what motivates people to engage. Factors as diverse as knowledge, power, culture, environment, lifestyle and personality often determine whether people heed warnings. Engaging people outside any warning system is called the “last mile” – a term that expresses the sentiment that warnings often do not reach those who need them most. Addressing vulnerability in disaster reduction is often similar to promoting development, but in the developed world “top-down” approaches to risk assessment and early warning dominate

    Drugs for preventing red blood cell dehydration in people with sickle cell disease.

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    BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications. Recent research has focused on therapies to rehydrate the sickled cells by reducing the loss of water and ions from them. Little is known about the effectiveness and safety of such drugs. This is an updated version of a previously published review. OBJECTIVES: To assess the relative risks and benefits of drugs to rehydrate sickled red blood cells. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group\u27s Haemoglobinopathies Trials Register.Last search of the Group\u27s Trials Register: 28 November 2015. SELECTION CRITERIA: Randomized or quasi-randomized controlled trials of drugs to rehydrate sickled red blood cells compared to placebo or an alternative treatment. DATA COLLECTION AND ANALYSIS: Both authors independently selected studies for inclusion, assessed study quality and extracted data. MAIN RESULTS: Of the 51 studies identified, three met the inclusion criteria. The first study tested the effectiveness of zinc sulphate to prevent sickle cell-related crises in a total of 145 participants and showed a significant reduction in painful crises over one and a half years, mean difference -2.83 (95% confidence interval -3.51 to -2.15). However, analysis was restricted due to limited statistical data. Changes to red cell parameters and blood counts were inconsistent. No serious adverse events were noted in the study.The second study was a Phase II dose-finding study of senicapoc (a Gardos channel blocker) compared to placebo. Compared to the placebo group the high dose senicapoc showed significant improvement in change in hemoglobin level, number and proportion of dense red blood cells, red blood cell count and indices and hematocrit. The results with low-dose senicapoc were similar to the high-dose senicapoc group but of lesser magnitude. There was no difference in the frequency of painful crises between the three groups. A subsequent Phase III study of senicapoc was terminated early since there was no difference observed between the treatment and control groups in the primary end point of painful crises. AUTHORS\u27 CONCLUSIONS: While the results of zinc for reducing sickle-related crises are encouraging, larger and longer-term multicenter studies are needed to evaluate the effectiveness of this therapy for people with sickle cell disease.While the Phase II and the prematurely terminated phase III studies of senicapoc showed that the drug improved red cell survival (depending on dose), this did not lead to fewer painful crises.We will continue to run searches to identify any potentially relevant trials; however, we do not plan to update other sections of the review until new trials are published

    Drugs for preventing red blood cell dehydration in people with sickle cell disease.

    Get PDF
    BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications. Recent research has focused on therapies to rehydrate the sickled cells by reducing the loss of water and ions from them. Little is known about the effectiveness and safety of such drugs. This is an updated version of a previously published review. OBJECTIVES: To assess the relative risks and benefits of drugs to rehydrate sickled red blood cells. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group\u27s Haemoglobinopathies Trials Register. We also searched online trials registries for any ongoing trials (01 July 2018).Last search of the Group\u27s Haemoglobinopathies Trials Register: 08 October 2018. SELECTION CRITERIA: Randomized or quasi-randomized controlled trials of drugs to rehydrate sickled red blood cells compared to placebo or an alternative treatment. DATA COLLECTION AND ANALYSIS: Both authors independently selected studies for inclusion, assessed study quality and extracted data. MAIN RESULTS: Of the 51 studies identified, three met the inclusion criteria, including 524 people with sickle cell disease aged between 12 and 65 years of age. One study tested the effectiveness of zinc sulphate as compared to placebo and the remaining two assessed senicapoc versus placebo. No deaths were seen in any of the studies (low-quality evidence). The zinc sulphate study showed a significant reduction in painful crises (in a total of 145 participants) over one and a half years, mean difference -2.83 (95% confidence interval -3.51 to -2.15) (moderate-quality evidence). However, analysis was restricted due to limited statistical data. Changes to red blood cell parameters and blood counts were inconsistent (very low-quality evidence). No serious adverse events were noted in the study. The Phase II dose-finding study of senicapoc (a Gardos channel blocker) compared to placebo showed that the high dose senicapoc showed significant improvement in change in hemoglobin level, the number and proportion of dense red blood cells, red blood cell count and indices and hematocrit value (very low-quality evidence). The results with low-dose senicapoc were similar to the high-dose senicapoc group but of lesser magnitude. There was no difference in the frequency of painful crises between the three groups (low-quality evidence). A subsequent Phase III study of senicapoc was terminated early since there was no difference observed between the treatment and control groups in the primary end point of painful crises. AUTHORS\u27 CONCLUSIONS: While the results of zinc for reducing sickle-related crises are encouraging, larger and longer-term multicenter studies are needed to evaluate the effectiveness of this therapy for people with sickle cell disease.While the Phase II and the prematurely terminated phase III studies of senicapoc showed that the drug improved red blood cell survival (depending on dose), this did not lead to fewer painful crises.Given this is no longer an active area of research, this review will no longer be regularly updated

    Refugees, Internally Displaced Persons, And International Humanitarian Law

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    The fact that war is the primary cause of people being uprooted prompts us to ask what protection the law of armed conflict affords refugees and displaced persons. How does humanitarian law protect groups of civilians from being forced to flee? What protection does it offer those who have nevertheless been uprooted, and how does that protection interrelate with refugee law? How can the Red Cross and Red Crescent organizations, in particular the International Committee of the Red Cross (“ICRC”), come to the aid of refugees and displaced persons? These are the questions this Article aims to answer. First, however, let us recall what international humanitarian law is

    [Review of] Fred McTaggart. Wolf That I Am: In Search of the Red Earth People

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    Fred McTaggart\u27s engaging narrative Wolf That I Am: In Search of the Red Earth People is as much a personalized story of self discovery as it is a discussion of surviving Mesquakie folklore. In the early 1970s, as a graduate student at the University of Iowa, McTaggart set out to gather and to analyze the folk stories told among Mesquakies, known historically to the non-Indian world as the combined Indian tribes of the Sac and Fox. Today the main body of this Native American group resides on a tribally-owned settlement (decidely [decidedly] not a government-controlled reservation as mentioned in the foreword) located along the Iowa River in east central Iowa

    Vulnerability report: inside the process of seeking asylum in Australia

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    This Report provides rare insights into the day to day realities of people seeking asylum to highlight the personal and human dimension of their plight.  This Report is the first of what will be an annual research contribution by Red Cross on key matters of social concern in Australia.This Vulnerability Report allows Red Cross and the wider community to hear about the nature and extent of vulnerability from the perspective of people seeking asylum. It helps us to understand the realities they face and to look for ways to ensure that, whether people return to their country of origin or are settled in Australia, they are supported during the time their application for asylum is processed.The five recommendations reached in the Report - with which UNHCR wholly concurs – provide a principled and sensible call for action.&nbsp

    Nicaraguan revolution : the people in red and black

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    En el presente artículo se analiza el proceso histórico-social de la revolución sandinista de 1979 haciendo foco en la huella que ésta dejó en los nicaragüenses. Nos proponemos realizar un recorrido por el proceso de la revolución sandinista nicaragüense, analizar sus antecedentes y posibles causas, así como también las consecuencias que trajo a este país centroamericano. También se analizará, someramente, el destino de la revolución con la ofensiva neoliberal en la década de los noventa. Se hará especial hincapié en la dimensión simbólica y cultural que hasta hoy conserva dicha revolución, pero sin dejar de hacer mención a las variables estructurales que condicionaron este proceso. La investigación se nutre de distintas fuentes documentales, así como de entrevistas y de una de las manifestaciones más ricas de la cultura: la música.The present article analyzes the socio-historical process of the Sandinista Revolution of 1979 focusing on the imprint that marked the life of Nicaraguan people. We aim to take a tour around the Nicaraguan Revolution process, analyze its background and potential causes, as well as the consequences that brought to this Central American country. We will also investigate, superficially, the fate of the revolution with a neoliberal offensive in the nineteenth century. Emphasis will be placed on the cultural and symbolic dimension that such revolution maintains until today, not to forget the structural variables which conditioned this process. The research draws on different documentary sources, such as interviews and one of the richest manifestations of culture: music.Fil: Palazzolo, Natalia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociale

    An Aching for Affection

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    As humans, we’ve needed companionship from the beginning of time. Therefore, what does a true relationship look like in today’s society? In this world of newly emerging relationships, many people have either experienced, seen, or heard of a toxic relationship. This article dives deep into what makes a toxic relationship, how to notice the red flags, and how to ultimately fix or end it
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