Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults.

ObjectivesThe current study examined recognition memory dysfunction and its neuroanatomical substrates in cognitively normal older adults and those diagnosed with mild cognitive impairment (MCI).MethodsParticipants completed the Mnemonic Similarity Task, which provides simultaneous measures of recognition memory and mnemonic discrimination. They also underwent structural neuroimaging to assess volume of medial temporal cortex and hippocampal subfields.ResultsAs expected, individuals diagnosed with MCI had significantly worse recognition memory performance and reduced volume across medial temporal cortex and hippocampal subfields relative to cognitively normal older adults. After controlling for diagnostic group differences, however, recognition memory was significantly related to whole hippocampus volume, and to volume of the dentate gyrus/CA3 subfield in particular. Recognition memory was also related to mnemonic discrimination, a fundamental component of episodic memory that has previously been linked to dentate gyrus/CA3 structure and function.DiscussionResults reveal that hippocampal subfield volume is sensitive to individual differences in recognition memory in older adults independent of clinical diagnosis. This supports the notion that episodic memory declines along a continuum within this age group, not just between diagnostic groups

Automated, high accuracy classification of Parkinsonian disorders: a pattern recognition approach

Progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and idiopathic Parkinson’s disease (IPD) can be clinically indistinguishable, especially in the early stages, despite distinct patterns of molecular pathology. Structural neuroimaging holds promise for providing objective biomarkers for discriminating these diseases at the single subject level but all studies to date have reported incomplete separation of disease groups. In this study, we employed multi-class pattern recognition to assess the value of anatomical patterns derived from a widely available structural neuroimaging sequence for automated classification of these disorders. To achieve this, 17 patients with PSP, 14 with IPD and 19 with MSA were scanned using structural MRI along with 19 healthy controls (HCs). An advanced probabilistic pattern recognition approach was employed to evaluate the diagnostic value of several pre-defined anatomical patterns for discriminating the disorders, including: (i) a subcortical motor network; (ii) each of its component regions and (iii) the whole brain. All disease groups could be discriminated simultaneously with high accuracy using the subcortical motor network. The region providing the most accurate predictions overall was the midbrain/brainstem, which discriminated all disease groups from one another and from HCs. The subcortical network also produced more accurate predictions than the whole brain and all of its constituent regions. PSP was accurately predicted from the midbrain/brainstem, cerebellum and all basal ganglia compartments; MSA from the midbrain/brainstem and cerebellum and IPD from the midbrain/brainstem only. This study demonstrates that automated analysis of structural MRI can accurately predict diagnosis in individual patients with Parkinsonian disorders, and identifies distinct patterns of regional atrophy particularly useful for this process

Side-View Face Recognition

Side-view face recognition is a challenging problem with many applications. Especially in real-life scenarios where the environment is uncontrolled, coping with pose variations up to side-view positions is an important task for face recognition. In this paper we discuss the use of side view face recognition techniques to be used in house safety applications. Our aim is to recognize people as they pass through a door, and estimate their location in the house. Here, we compare available databases appropriate for this task, and review current methods for profile face recognition

An M-QAM Signal Modulation Recognition Algorithm in AWGN Channel

Computing the distinct features from input data, before the classification, is a part of complexity to the methods of Automatic Modulation Classification (AMC) which deals with modulation classification was a pattern recognition problem. Although the algorithms that focus on MultiLevel Quadrature Amplitude Modulation (M-QAM) which underneath different channel scenarios was well detailed. A search of the literature revealed indicates that few studies were done on the classification of high order M-QAM modulation schemes like128-QAM, 256-QAM, 512-QAM and1024-QAM. This work is focusing on the investigation of the powerful capability of the natural logarithmic properties and the possibility of extracting Higher-Order Cumulant's (HOC) features from input data received raw. The HOC signals were extracted under Additive White Gaussian Noise (AWGN) channel with four effective parameters which were defined to distinguished the types of modulation from the set; 4-QAM~1024-QAM. This approach makes the recognizer more intelligent and improves the success rate of classification. From simulation results, which was achieved under statistical models for noisy channels, manifest that recognized algorithm executes was recognizing in M-QAM, furthermore, most results were promising and showed that the logarithmic classifier works well over both AWGN and different fading channels, as well as it can achieve a reliable recognition rate even at a lower signal-to-noise ratio (less than zero), it can be considered as an Integrated Automatic Modulation Classification (AMC) system in order to identify high order of M-QAM signals that applied a unique logarithmic classifier, to represents higher versatility, hence it has a superior performance via all previous works in automatic modulation identification systemComment: 18 page