Towards knowledge-based gene expression data mining

The field of gene expression data analysis has grown in the past few years from being purely data-centric to integrative, aiming at complementing microarray analysis with data and knowledge from diverse available sources. In this review, we report on the plethora of gene expression data mining techniques and focus on their evolution toward knowledge-based data analysis approaches. In particular, we discuss recent developments in gene expression-based analysis methods used in association and classification studies, phenotyping and reverse engineering of gene networks

Run-time risk management in adaptive ICT systems

We will present results of the SERSCIS project related to risk management and mitigation strategies in adaptive multi-stakeholder ICT systems. The SERSCIS approach involves using semantic threat models to support automated design-time threat identification and mitigation analysis. The focus of this paper is the use of these models at run-time for automated threat detection and diagnosis. This is based on a combination of semantic reasoning and Bayesian inference applied to run-time system monitoring data. The resulting dynamic risk management approach is compared to a conventional ISO 27000 type approach, and validation test results presented from an Airport Collaborative Decision Making (A-CDM) scenario involving data exchange between multiple airport service providers

Automated data integration for developmental biological research

In an era exploding with genome-scale data, a major challenge for developmental biologists is how to extract significant clues from these publicly available data to benefit our studies of individual genes, and how to use them to improve our understanding of development at a systems level. Several studies have successfully demonstrated new approaches to classic developmental questions by computationally integrating various genome-wide data sets. Such computational approaches have shown great potential for facilitating research: instead of testing 20,000 genes, researchers might test 200 to the same effect. We discuss the nature and state of this art as it applies to developmental research