609 research outputs found
1st INCF Workshop on Sustainability of Neuroscience Databases
The goal of the workshop was to discuss issues related to the sustainability of neuroscience databases, identify problems and propose solutions, and formulate recommendations to the INCF. The report summarizes the discussions of invited participants from the neuroinformatics community as well as from other disciplines where sustainability issues have already been approached. The recommendations for the INCF involve rating, ranking, and supporting database sustainability
Meeting Report from the Second 'Minimum Information for Biological and Biomedical Investigations (MIBBI) workshop
Face-to-face meetings play a central role in the birth and maturation of communities. Intensive workshops filled with presentations, discussions and working group meetings have always been at the heart of the activities of the Genomic Standards Consortium (GSC). Such work-driven meetings are a key way in which the GSC fulfils its mission. Similarly, meeting reports provide a key mechanism for preserving and disseminating the consensus built at such meetings as they describe the range of speakers and participants present, topics covered and key outcomes and priorities agreed upon by the community.This issue contains a total of nine meeting reports, from workshops held between April and October 2010 that are presented to the reader to provide a broad overview of ongoing GSC activities and initiatives
SYSTEMATIC LITERATURE REVIEW: DATA STANDARDIZATION IN HEALTH INFORMATION SYSTEMS
Digitalization within the healthcare sector has resulted in the accumulation of vast amounts of data that can be utilized towards the improvement of health outcomes. Meaningful use of such data, however, requires that it is standardized. Standardization plays a key role in providing a universal language for data that is exchanged through different health systems. Through a systematic literature review, this paper identifies practices that are vital for an effective standardization process. Ontological development, governance and organizational practices are identified as pertinent to the process of standardization and are analyzed and explained through the lens of a multi-thread social activity model by Fomin et al. (2003). This model provides a comprehensive view of related aspects of design, sense-making, and negotiation. The analysis shows that all these aspects take place in all stages of the standardization process, and they are highly dependent on each other and can occur simultaneously
Improving reproducibility and reuse of modelling results in the life sciences
Research results are complex and include a variety of heterogeneous data. This entails major computational challenges to (i) to manage simulation studies, (ii) to ensure model exchangeability, stability and validity, and (iii) to foster communication between partners. I describe techniques to improve the reproducibility and reuse of modelling results. First, I introduce a method to characterise differences in computational models. Second, I present approaches to obtain shareable and reproducible research results. Altogether, my methods and tools foster exchange and reuse of modelling results.Die verteilte Entwicklung von komplexen Simulationsstudien birgt eine groĂe Zahl an informationstechnischen Herausforderungen: (i) Modelle mĂŒssen verwaltet werden; (ii) Reproduzierbarkeit, StabilitĂ€t und GĂŒltigkeit von Ergebnissen muss sichergestellt werden; und (iii) die Kommunikation zwischen Partnern muss verbessert werden. Ich stelle Techniken vor, um die Reproduzierbarkeit und Wiederverwendbarkeit von Modellierungsergebnissen zu verbessern. Meine Implementierungen wurden erfolgreich in internationalen Anwendungen integriert und fördern das Teilen von wissenschaftlichen Ergebnissen
CARMEN [Code, Analysis, Repository & Modelling for e-Neuroscience]
The CARMEN pilot project seeks to create a virtual laboratory for
experimental neurophysiology, enabling the sharing and collaborative
exploitation of data, analysis code and expertise. This study by the DCC
contributes to an understanding of the data curation requirements of the
eScience community, through its extended observation of the CARMEN
neurophysiology communityâs specification and selection of solutions for the
organisation, access and curation of digital research output
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.
Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently counteract the increased excitatory drive to CA1 neurons in AppNL-G-F mice, but that this mechanism fails in older mice. Spatial transcriptomics analysis identifies Pmch as part of the adaptive response in AppNL-G-F mice. Pmch encodes melanin-concentrating hormone (MCH), which is produced in sleep-active lateral hypothalamic neurons that project to CA1 and modulate memory. We show that MCH downregulates synaptic transmission, modulates firing rate homeostasis in hippocampal neurons and reverses the increased excitatory drive to CA1 neurons in AppNL-G-F mice. AppNL-G-F mice spend less time in rapid eye movement (REM) sleep. AppNL-G-F mice and individuals with AD show progressive changes in morphology of CA1-projecting MCH axons. Our findings identify the MCH system as vulnerable in early AD and suggest that impaired MCH-system function contributes to aberrant excitatory drive and sleep defects, which can compromise hippocampus-dependent functions
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