13,569 research outputs found
Holographic quantum error-correcting codes: Toy models for the bulk/boundary correspondence
We propose a family of exactly solvable toy models for the AdS/CFT
correspondence based on a novel construction of quantum error-correcting codes
with a tensor network structure. Our building block is a special type of tensor
with maximal entanglement along any bipartition, which gives rise to an
isometry from the bulk Hilbert space to the boundary Hilbert space. The entire
tensor network is an encoder for a quantum error-correcting code, where the
bulk and boundary degrees of freedom may be identified as logical and physical
degrees of freedom respectively. These models capture key features of
entanglement in the AdS/CFT correspondence; in particular, the Ryu-Takayanagi
formula and the negativity of tripartite information are obeyed exactly in many
cases. That bulk logical operators can be represented on multiple boundary
regions mimics the Rindler-wedge reconstruction of boundary operators from bulk
operators, realizing explicitly the quantum error-correcting features of
AdS/CFT recently proposed by Almheiri et. al in arXiv:1411.7041.Comment: 40 Pages + 25 Pages of Appendices. 38 figures. Typos and
bibliographic amendments and minor correction
Extended two-stage adaptive designswith three target responses forphase II clinical trials
We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization tofind extended two-stage adaptive optimal designs that allow three target response rates for the drug in a phase II trial.Our proposed designs include the celebrated Simon’s two-stage design and its extension that allows two target responserates to be specified for the drug. We show that discrete particle swarm optimization not only frequently outperformsgreedy algorithms, which are currently used to find such designs when there are only a few parameters; it is also capableof solving design problems posed here with more parameters that greedy algorithms cannot solve. In stage 1 of ourproposed designs, futility is quickly assessed and if there are sufficient responders to move to stage 2, one tests one ofthe three target response rates of the drug, subject to various user-specified testing error rates. Our designs aretherefore more flexible and interestingly, do not necessarily require larger expected sample size requirements thantwo-stage adaptive designs. Using a real adaptive trial for melanoma patients, we show our proposed design requires onehalf fewer subjects than the implemented design in the study
A single-photon sampling architecture for solid-state imaging
Advances in solid-state technology have enabled the development of silicon
photomultiplier sensor arrays capable of sensing individual photons. Combined
with high-frequency time-to-digital converters (TDCs), this technology opens up
the prospect of sensors capable of recording with high accuracy both the time
and location of each detected photon. Such a capability could lead to
significant improvements in imaging accuracy, especially for applications
operating with low photon fluxes such as LiDAR and positron emission
tomography.
The demands placed on on-chip readout circuitry imposes stringent trade-offs
between fill factor and spatio-temporal resolution, causing many contemporary
designs to severely underutilize the technology's full potential. Concentrating
on the low photon flux setting, this paper leverages results from group testing
and proposes an architecture for a highly efficient readout of pixels using
only a small number of TDCs, thereby also reducing both cost and power
consumption. The design relies on a multiplexing technique based on binary
interconnection matrices. We provide optimized instances of these matrices for
various sensor parameters and give explicit upper and lower bounds on the
number of TDCs required to uniquely decode a given maximum number of
simultaneous photon arrivals.
To illustrate the strength of the proposed architecture, we note a typical
digitization result of a 120x120 photodiode sensor on a 30um x 30um pitch with
a 40ps time resolution and an estimated fill factor of approximately 70%, using
only 161 TDCs. The design guarantees registration and unique recovery of up to
4 simultaneous photon arrivals using a fast decoding algorithm. In a series of
realistic simulations of scintillation events in clinical positron emission
tomography the design was able to recover the spatio-temporal location of 98.6%
of all photons that caused pixel firings.Comment: 24 pages, 3 figures, 5 table
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