Greedy low-rank algorithm for spatial connectome regression

Recovering brain connectivity from tract tracing data is an important computational problem in the neurosciences. Mesoscopic connectome reconstruction was previously formulated as a structured matrix regression problem (Harris et al., 2016), but existing techniques do not scale to the whole-brain setting. The corresponding matrix equation is challenging to solve due to large scale, ill-conditioning, and a general form that lacks a convergent splitting. We propose a greedy low-rank algorithm for connectome reconstruction problem in very high dimensions. The algorithm approximates the solution by a sequence of rank-one updates which exploit the sparse and positive definite problem structure. This algorithm was described previously (Kressner and Sirkovi\'c, 2015) but never implemented for this connectome problem, leading to a number of challenges. We have had to design judicious stopping criteria and employ efficient solvers for the three main sub-problems of the algorithm, including an efficient GPU implementation that alleviates the main bottleneck for large datasets. The performance of the method is evaluated on three examples: an artificial "toy" dataset and two whole-cortex instances using data from the Allen Mouse Brain Connectivity Atlas. We find that the method is significantly faster than previous methods and that moderate ranks offer good approximation. This speedup allows for the estimation of increasingly large-scale connectomes across taxa as these data become available from tracing experiments. The data and code are available online

On the causal interpretation of acyclic mixed graphs under multivariate normality

In multivariate statistics, acyclic mixed graphs with directed and bidirected edges are widely used for compact representation of dependence structures that can arise in the presence of hidden (i.e., latent or unobserved) variables. Indeed, under multivariate normality, every mixed graph corresponds to a set of covariance matrices that contains as a full-dimensional subset the covariance matrices associated with a causally interpretable acyclic digraph. This digraph generally has some of its nodes corresponding to hidden variables. We seek to clarify for which mixed graphs there exists an acyclic digraph whose hidden variable model coincides with the mixed graph model. Restricting to the tractable setting of chain graphs and multivariate normality, we show that decomposability of the bidirected part of the chain graph is necessary and sufficient for equality between the mixed graph model and some hidden variable model given by an acyclic digraph

Low thrust interplanetary trajectory open loop error analysis, volume 1 Final report

Computer program for open-loop error analysis of low thrust interplanetary trajectorie