724 research outputs found
The LBFGS Quasi-Newtonian Method for Molecular Modeling Prion AGAAAAGA Amyloid Fibrils
Experimental X-ray crystallography, NMR (Nuclear Magnetic Resonance)
spectroscopy, dual polarization interferometry, etc are indeed very powerful
tools to determine the 3-Dimensional structure of a protein (including the
membrane protein); theoretical mathematical and physical computational
approaches can also allow us to obtain a description of the protein 3D
structure at a submicroscopic level for some unstable, noncrystalline and
insoluble proteins. X-ray crystallography finds the X-ray final structure of a
protein, which usually need refinements using theoretical protocols in order to
produce a better structure. This means theoretical methods are also important
in determinations of protein structures. Optimization is always needed in the
computer-aided drug design, structure-based drug design, molecular dynamics,
and quantum and molecular mechanics. This paper introduces some optimization
algorithms used in these research fields and presents a new theoretical
computational method - an improved LBFGS Quasi-Newtonian mathematical
optimization method - to produce 3D structures of Prion AGAAAAGA amyloid
fibrils (which are unstable, noncrystalline and insoluble), from the potential
energy minimization point of view. Because the NMR or X-ray structure of the
hydrophobic region AGAAAAGA of prion proteins has not yet been determined, the
model constructed by this paper can be used as a reference for experimental
studies on this region, and may be useful in furthering the goals of medicinal
chemistry in this field
A Simple and Efficient Algorithm for Nonlinear Model Predictive Control
We present PANOC, a new algorithm for solving optimal control problems
arising in nonlinear model predictive control (NMPC). A usual approach to this
type of problems is sequential quadratic programming (SQP), which requires the
solution of a quadratic program at every iteration and, consequently, inner
iterative procedures. As a result, when the problem is ill-conditioned or the
prediction horizon is large, each outer iteration becomes computationally very
expensive. We propose a line-search algorithm that combines forward-backward
iterations (FB) and Newton-type steps over the recently introduced
forward-backward envelope (FBE), a continuous, real-valued, exact merit
function for the original problem. The curvature information of Newton-type
methods enables asymptotic superlinear rates under mild assumptions at the
limit point, and the proposed algorithm is based on very simple operations:
access to first-order information of the cost and dynamics and low-cost direct
linear algebra. No inner iterative procedure nor Hessian evaluation is
required, making our approach computationally simpler than SQP methods. The
low-memory requirements and simple implementation make our method particularly
suited for embedded NMPC applications
Unconstrained Optimization with MINTOOLKIT for GNU Octave
The paper documents MINTOOLKIT for GNU Octave. MINTOOLKIT provides functions for minimization and numeric differentiation. The main algorithms are BFGS, LBFGS, and simulated annealing. Examples are given.minimization, optmization, software
Global convergence of the nonmonotone MBFGS method for nonconvex unconstrained minimization
AbstractIn this paper, we propose a new nonmonotone Armijo type line search and prove that the MBFGS method proposed by Li and Fukushima with this new line search converges globally for nonconvex minimization. Some numerical experiments show that this nonmonotone MBFGS method is efficient for the given test problems
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