43,666 research outputs found

    Geometric origin of coincidences and hierarchies in the landscape

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    We show that the geometry of cutoffs on eternal inflation strongly constrains predictions for the timescales of vacuum domination, curvature domination, and observation. We consider three measure proposals: the causal patch, the fat geodesic, and the apparent horizon cutoff, which is introduced here for the first time. We impose neither anthropic requirements nor restrictions on landscape vacua. For vacua with positive cosmological constant, all three measures predict the double coincidence that most observers live at the onset of vacuum domination and just before the onset of curvature domination. The hierarchy between the Planck scale and the cosmological constant is related to the number of vacua in the landscape. These results require only mild assumptions about the distribution of vacua (somewhat stronger assumptions are required by the fat geodesic measure). At this level of generality, none of the three measures are successful for vacua with negative cosmological constant. Their applicability in this regime is ruled out unless much stronger anthropic requirements are imposed.Comment: 34 pages, 5 figure

    Combining Coarse-Grained Protein Models with Replica-Exchange All-Atom Molecular Dynamics

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    We describe a combination of all-atom simulations with CABS, a well-established coarse-grained protein modeling tool, into a single multiscale protocol. The simulation method has been tested on the C-terminal beta hairpin of protein G, a model system of protein folding. After reconstructing atomistic details, conformations derived from the CABS simulation were subjected to replica-exchange molecular dynamics simulations with OPLS-AA and AMBER99sb force fields in explicit solvent. Such a combination accelerates system convergence several times in comparison with all-atom simulations starting from the extended chain conformation, demonstrated by the analysis of melting curves, the number of native-like conformations as a function of time and secondary structure propagation. The results strongly suggest that the proposed multiscale method could be an efficient and accurate tool for high-resolution studies of protein folding dynamics in larger systems.Comment: 12 pages, 4 figure

    Vacuum Structure and the Arrow of Time

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    We find ourselves in an extended era of entropy production. Unlike most other observations, the arrow of time is usually regarded as a constraint on initial conditions. I argue, however, that it primarily constrains the vacuum structure of the theory. I exhibit simple scalar field potentials in which low-entropy initial conditions are not necessary, or not sufficient, for an arrow of time to arise. I argue that the string theory landscape gives rise to an arrow of time independently of the initial entropy, assuming a plausible condition on the lifetime of its metastable vacua. The dynamical resolution of the arrow of time problem arises from the same structural properties of the string landscape that allow it to solve the cosmological constant problem without producing an empty universe, particularly its high dimensionality and the large difference in vacuum energy between neighboring vacua.Comment: 31 pages JHEP format, 3 figure

    The blob and the block. When the rhetoric of the smooth and the striated went all wrong

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    This paper conforms to a view of architecture and the distribution of urban space as bio-political parameters of dominance and resistance. Using G. Deleuze & F. Guattari’s seminal essay on 1444. The Smooth and the Striated, I intend to show how Global Capitalism, by replicating the discourse of the smooth and the ungraspable, has voided Dialectics of its subversive potential.El presente artículo contempla la arquitectura y la distribución del espacio urbano como parámetros biopolíticos de dominación y resistencia. Valiéndose del ensayo 1444. Lo liso y lo estriado, de Gilles Deleuze & Felix Guattari, se pretende demostrar cómo el capitalismo global, gracias a su capacidad para emular el discurso de lo fluido y lo intangible, habrá conseguido despojar a lo dialéctico de su potencial subversivo

    Building Damage-Resilient Dominating Sets in Complex Networks against Random and Targeted Attacks

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    We study the vulnerability of dominating sets against random and targeted node removals in complex networks. While small, cost-efficient dominating sets play a significant role in controllability and observability of these networks, a fixed and intact network structure is always implicitly assumed. We find that cost-efficiency of dominating sets optimized for small size alone comes at a price of being vulnerable to damage; domination in the remaining network can be severely disrupted, even if a small fraction of dominator nodes are lost. We develop two new methods for finding flexible dominating sets, allowing either adjustable overall resilience, or dominating set size, while maximizing the dominated fraction of the remaining network after the attack. We analyze the efficiency of each method on synthetic scale-free networks, as well as real complex networks
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