Enhancing reuse of data and biological material in medical research : from FAIR to FAIR-Health

The known challenge of underutilization of data and biological material from biorepositories as potential resources formedical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and reusability—entitled FAIR Principles (Findability, Accessibility, Interoperability, and Reusability)—are likely to address only parts of the problem. In this article,we argue that biologicalmaterial and data should be viewed as a unified resource. This approach would facilitate access to complete provenance information, which is a prerequisite for reproducibility and meaningful integration of the data. A unified view also allows for optimization of long-term storage strategies, as demonstrated in the case of biobanks.Wepropose an extension of the FAIR Principles to include the following additional components: (1) quality aspects related to research reproducibility and meaningful reuse of the data, (2) incentives to stimulate effective enrichment of data sets and biological material collections and its reuse on all levels, and (3) privacy-respecting approaches for working with the human material and data. These FAIR-Health principles should then be applied to both the biological material and data. We also propose the development of common guidelines for cloud architectures, due to the unprecedented growth of volume and breadth of medical data generation, as well as the associated need to process the data efficiently.peer-reviewe

Collaborative Reuse of Streaming Dataflows in IoT Applications

Distributed Stream Processing Systems (DSPS) like Apache Storm and Spark Streaming enable composition of continuous dataflows that execute persistently over data streams. They are used by Internet of Things (IoT) applications to analyze sensor data from Smart City cyber-infrastructure, and make active utility management decisions. As the ecosystem of such IoT applications that leverage shared urban sensor streams continue to grow, applications will perform duplicate pre-processing and analytics tasks. This offers the opportunity to collaboratively reuse the outputs of overlapping dataflows, thereby improving the resource efficiency. In this paper, we propose \emph{dataflow reuse algorithms} that given a submitted dataflow, identifies the intersection of reusable tasks and streams from a collection of running dataflows to form a \emph{merged dataflow}. Similar algorithms to unmerge dataflows when they are removed are also proposed. We implement these algorithms for the popular Apache Storm DSPS, and validate their performance and resource savings for 35 synthetic dataflows based on public OPMW workflows with diverse arrival and departure distributions, and on 21 real IoT dataflows from RIoTBench.Comment: To appear in IEEE eScience Conference 201

From Causes for Database Queries to Repairs and Model-Based Diagnosis and Back

In this work we establish and investigate connections between causes for query answers in databases, database repairs wrt. denial constraints, and consistency-based diagnosis. The first two are relatively new research areas in databases, and the third one is an established subject in knowledge representation. We show how to obtain database repairs from causes, and the other way around. Causality problems are formulated as diagnosis problems, and the diagnoses provide causes and their responsibilities. The vast body of research on database repairs can be applied to the newer problems of computing actual causes for query answers and their responsibilities. These connections, which are interesting per se, allow us, after a transition -inspired by consistency-based diagnosis- to computational problems on hitting sets and vertex covers in hypergraphs, to obtain several new algorithmic and complexity results for database causality.Comment: To appear in Theory of Computing Systems. By invitation to special issue with extended papers from ICDT 2015 (paper arXiv:1412.4311

The ‘Right’ Price for Art Collectibles. A Quantile Hedonic Regression Investigation of Picasso Paintings

Different art objects are likely to be priced by means of different systems of hedonic characteristics; more precisely, different evaluation procedures for high and low price items are often postulated. However, the empirical evidence on this point is scant. The main purpose of this paper is to fill this gap by using the quantile hedonic regression approach. The empirical evidence, based on a data set of 716 Picasso paintings sold at auction worldwide, highlights the critical role of the price classes in determining the evaluation criteria of art items.hedonic price; auction; quantile regression; painting; Picasso