Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Metals have unique characteristics such as variable coordination modes, redox activity, and reactivity being indispensable for several biochemical processes in cells. Due to their reactivity, their concentration is tightly regulated inside the cells, and abnormal concentrations are associated with many disorders, such as cancer. As such metal complexes turned out to be very attractive as potential anticancer agents. The discovery of cisplatin was a crucial moment, which prompted the interest in Pt(II) and other metal complexes as potential anticancer agents. This chapter highlights the state of the art on metal complexes in cancer therapy, highlighting their uptake mechanisms, biological targets, toxicity, and drug resistance. Finally, based on the importance of selective target of cancer cells, drug delivery systems will also be discussed

Woman, Life, Freedom : A Movement in Progress in Iran

On September 16, 2022, a new movement began in Iran. It shows the potential to be a serious uprising. The death of an Iranian woman in the street in Tehran, the capital of Iran, due to being beaten by morality police because she was wearing an unappropriated hijab sparked the uprising. Her death was a result of wearing an “inappropriate” hijab. This was an excuse that turned on people’s anger not only because of hijab but also because there are many other combinations of causes to bring out people for protest. This movement was started because people were dissatisfied with how the government managed the whole system and the use of pressure to control people, especially women, in different aspects of their lives. The slogan “Woman, Life, Freedom,” which has been used in all of the demonstrations that have taken place both inside and outside of Iran, shows what the Iranian people exact need, woman’s rights, the ability to provide at least essential living requirements, and the possibility to talk against dissatisfactions. Now “Woman, Life, Freedom” has become a movement

After Bergson: Temporal Countermoves in Ahmet Hamdi Tanpinar\u27s The Time Regulation Institute and Uwe Johnson\u27s Speculations about Jakob

As modernity, that hopeful age of man and reason, broke from the inside out –– with World War 2, with Holocaust, with totalitarian attempts at modernization across the globe –– many frustrated artists turned their attention to dissecting and criticizing it, if not abandoning it wholly for something better. One specific focus of this pushback has been how modernity perceived daily and historical time, its philosophical arms-supplier being Henri Bergson, the fin-de-siecle French thinker on time. Here I read two 1950s novels, one from authoritarian-capitalist Turkey and the other from communist East Germany, as philosophical novels inspired by Bergson –– Ahmet Hamdi Tanpinar’s The Time Regulation Institute and Uwe Johnson’s Speculations about Jakob –– and catalogue the many intriguing ways in which they criticize the abstract time of hours and seconds and the linear and teleological understanding of history. In the end arises a cross-national upholding of Bergsonian duration, an understanding of time as movement instead of a series of moments, both in the life of the individual and that of political peoples, from which blooms a recognition of human freedom

The Syrophoenician Woman

Matthew 15:21-28

Behind the Lines

This creative writing thesis contains fiction by Idalis Nieves

The Penobskan Porcupine Panic

This creative writing thesis takes its origins from a ten-page story written for a fiction class in the spring of 2015 and inspired by the song Penobska Oakwalk from the band Quilt

Charles M. Breder, Jr.: Bahamas and Florida

Dr. Charles M. Breder, a well known ichthyologist, kept meticulous field diaries throughout his career. This publication is a transcription of field notes recorded during the Bacon Andros Expeditions, and trips to Florida, Ohio and Illinois during the 1930s. Breder's work in Andros included exploration of a "blue hole", inland ecosystems, and collection of marine and terrestrial specimens. Anecdotes include descriptions of camping on the beach, the "filly-mingoes" (flamingos) of Andros Island, the Marine Studios of Jacksonville, FL, a trip to Havana, and the birth of seahorses. This publication is part of a series of transcriptions of Dr. Breder's diaries. (PDF contains 55 pages