Design, Fabrication, and Validation of a Highly Miniaturized Wirelessly Powered Neural Implant

We have recently witnessed an explosion in the number of neurons that can be recorded and/or stimulated simultaneously during neurophysiological experiments. Experiments have progressed from recording or stimulation with a single electrode to Micro-Electrode Array (MEA) such as the Utah Array. These MEAs can be instrumented with current drivers, neural amplifiers, digitizers and wireless communication links. The broad interest in these MEAs suggests that there is a need for large scale neural recording and stimulation. The ultimate goal is to coordinate the recordings and stimulation of potentially thousands of neurons from many brain areas. Unfortunately, current state-of-the-art MEAs are limited by their scalability and long-term stability because of their physical size and rigid configuration. Furthermore, some applications prioritize a distributed neural interface over one that offers high resolution. Examples of biomedical applications that necessitate an interface with neurons from many sites in the brain include: i) understanding and treating neurological disorders that affect distributed locations throughout the CNS; ii) revolutionizing our understanding of the brain by studying the correlations between neural networks from different regions of the brain and the mechanisms of cognitive functions; and iii) covering larger area in the sensorimotor cortex of amputees to more accurately control robotic prosthetic limbs or better evoke a sense of touch. One solution to make large scale, fully specifiable, electrical stimulation and recording possible, is to disconnect the electrodes from the base, so that they can be arbitrarily placed, using a syringe, freely in the nervous system. To overcome the challenges of system miniaturization, we propose the “microbead”, an ultra-small neural stimulating implant, that is currently implemented in a 130nm CMOS technology with the following characteristics: 200 μm × 200 μm × 80 μm size; optimized wireless powering, all micro-electronics on single chip; and integrated electrodes and coil. The stimulating microbead is validated in a sciatic nerve by generating leg movements. A recording microbead is also investigated with following characteristics: wireless powering using steerable phased coil array, miniaturized front-end, and backscattering telemetry. These microbeads could eventually replace the rigid arrays that are currently the state-of-the-art in electrophysiology set-ups

A Class-E Inductive Powering Link with Backward Data Communications for Implantable Sensor Systems

The design and implementation of a wireless power and data transfer system based on inductive coupling, having the potential to be used in numerous implantable bio-medical sensors and systems, is presented. The system consists of an external (primary) unit and an internal (secondary) unit. The external unit incorporates a high-efficiency switch-mode Class-E amplifier operating at ~200 kHz for driving the primary coil. The secondary unit consists of a parallel resonant coil followed by the power recovery circuitry. Means for backward data communication from the internal to the external unit over the same pair of coils has been realized using a simple FSK-based modulation scheme incorporated into the internal unit. FSK demodulation and associated filtering are integrated with the base inductive powering system. Prototype system test results indicate the inductive link efficiency can exceed 80% under optimum operating conditions with the overall power transfer efficiency of approximately 30%. The communication system is capable of transmitting up to 10kbps of data with the FSK carrier frequency (i.e., middle-frequency) being only 120kHz. The complete system functions reliably over an inter-coil distances exceeding 2.5cm with a 5V dc supply

Intra-Body Communications for Nervous System Applications: Current Technologies and Future Directions

The Internet of Medical Things (IoMT) paradigm will enable next generation healthcare by enhancing human abilities, supporting continuous body monitoring and restoring lost physiological functions due to serious impairments. This paper presents intra-body communication solutions that interconnect implantable devices for application to the nervous system, challenging the specific features of the complex intra-body scenario. The presented approaches include both speculative and implementative methods, ranging from neural signal transmission to testbeds, to be applied to specific neural diseases therapies. Also future directions in this research area are considered to overcome the existing technical challenges mainly associated with miniaturization, power supply, and multi-scale communications.Comment: https://www.sciencedirect.com/science/article/pii/S138912862300163

Doctor of Philosophy

dissertationSince the late 1950s, scientists have been working toward realizing implantable devices that would directly monitor or even control the human body's internal activities. Sophisticated microsystems are used to improve our understanding of internal biological processes in animals and humans. The diversity of biomedical research dictates that microsystems must be developed and customized specifically for each new application. For advanced long-term experiments, a custom designed system-on-chip (SoC) is usually necessary to meet desired specifications. Custom SoCs, however, are often prohibitively expensive, preventing many new ideas from being explored. In this work, we have identified a set of sensors that are frequently used in biomedical research and developed a single-chip integrated microsystem that offers the most commonly used sensor interfaces, high computational power, and which requires minimum external components to operate. Included peripherals can also drive chemical reactions by setting the appropriate voltages or currents across electrodes. The SoC is highly modular and well suited for prototyping in and ex vivo experimental devices. The system runs from a primary or secondary battery that can be recharged via two inductively coupled coils. The SoC includes a 16-bit microprocessor with 32 kB of on chip SRAM. The digital core consumes 350 μW at 10 MHz and is capable of running at frequencies up to 200 MHz. The integrated microsystem has been fabricated in a 65 nm CMOS technology and the silicon has been fully tested. Integrated peripherals include two sigma-delta analog-to-digital converters, two 10-bit digital-to-analog converters, and a sleep mode timer. The system also includes a wireless ultra-wideband (UWB) transmitter. The fullydigital transmitter implementation occupies 68 x 68 μm2 of silicon area, consumes 0.72 μW static power, and achieves an energy efficiency of 19 pJ/pulse at 200 MHz pulse repetition frequency. An investigation of the suitability of the UWB technology for neural recording systems is also presented. Experimental data capturing the UWB signal transmission through an animal head are presented and a statistical model for large-scale signal fading is developed

Beyond solid-state lighting: Miniaturization, hybrid integration, and applications og GaN nano- and micro-LEDs

Gallium Nitride (GaN) light-emitting-diode (LED) technology has been the revolution in modern lighting. In the last decade, a huge global market of efficient, long-lasting and ubiquitous white light sources has developed around the inception of the Nobel-price-winning blue GaN LEDs. Today GaN optoelectronics is developing beyond lighting, leading to new and innovative devices, e.g. for micro-displays, being the core technology for future augmented reality and visualization, as well as point light sources for optical excitation in communications, imaging, and sensing. This explosion of applications is driven by two main directions: the ability to produce very small GaN LEDs (microLEDs and nanoLEDs) with high efficiency and across large areas, in combination with the possibility to merge optoelectronic-grade GaN microLEDs with silicon microelectronics in a fully hybrid approach. GaN LED technology today is even spreading into the realm of display technology, which has been occupied by organic LED (OLED) and liquid crystal display (LCD) for decades. In this review, the technological transition towards GaN micro- and nanodevices beyond lighting is discussed including an up-to-date overview on the state of the art

A Three – tier bio-implantable sensor monitoring and communications platform

One major hindrance to the advent of novel bio-implantable sensor technologies is the need for a reliable power source and data communications platform capable of continuously, remotely, and wirelessly monitoring deeply implantable biomedical devices. This research proposes the feasibility and potential of combining well established, ‘human-friendly' inductive and ultrasonic technologies to produce a proof-of-concept, generic, multi-tier power transfer and data communication platform suitable for low-power, periodically-activated implantable analogue bio-sensors. In the inductive sub-system presented, 5 W of power is transferred across a 10 mm gap between a single pair of 39 mm (primary) and 33 mm (secondary) circular printed spiral coils (PSCs). These are printed using an 8000 dpi resolution photoplotter and fabricated on PCB by wet-etching, to the maximum permissible density. Our ultrasonic sub-system, consisting of a single pair of Pz21 (transmitter) and Pz26 (receiver) piezoelectric PZT ceramic discs driven by low-frequency, radial/planar excitation (-31 mode), without acoustic matching layers, is also reported here for the first time. The discs are characterised by propagation tank test and directly driven by the inductively coupled power to deliver 29 μW to a receiver (implant) employing a low voltage start-up IC positioned 70 mm deep within a homogeneous liquid phantom. No batteries are used. The deep implant is thus intermittently powered every 800 ms to charge a capacitor which enables its microcontroller, operating with a 500 kHz clock, to transmit a single nibble (4 bits) of digitized sensed data over a period of ~18 ms from deep within the phantom, to the outside world. A power transfer efficiency of 83% using our prototype CMOS logic-gate IC driver is reported for the inductively coupled part of the system. Overall prototype system power consumption is 2.3 W with a total power transfer efficiency of 1% achieved across the tiers

Miniaturized antenna and transponder based wireless sensors for internet of things in healthcare

Future medical and healthcare systems will be largely improved by the wide-spreading of internet of things (IoTs). One of the crucial challenges of IoTs for healthcare is at the wireless sensors. Miniaturization of sensor node profile, minimizing power consumption as well as lowering down design/production cost of antenna, RF circuits and sensor modules have become the key issues for realizing more exciting applications in medical and healthcare fields that never seemed to be possible before. In this dissertation work, we first focus on electrically small antenna (ESA) design and fabrication for medical telemetry. A comprehensive analysis of the radiation properties of a novel electrically small folded ellipsoidal ESA is presented, showing its ability to self-resonate and impedance match without external components. It will benefit various size-restricted applications especially with wireless medical implants. The second focus is on healthcare sensors using ESA as the sensing agent, which saves the power and cost by eliminating the need of extra sensing modules. Specifically, miniaturized helix ESAs are integrated with drug reservoirs to function as wireless transponder sensors for real-time drug dosage monitoring. We also introduce a system level innovation of a passive wireless harmonic transponder/harmonic sniffer/frequency hopped interrogator based sensing system. The μL- liquid level resolution and absolute-accuracy passive sensing is demonstrated in the presence of strong direct coupling, background scatters, distance variance as well as near-filed human body movement interference. Furthermore, we investigate how modern ubiquitous wireless sensor networks could take advantage of sensitive nanostructure materials for enhanced performance. Here we propose a new paradigm of chemically-gated mixed modulation on a single homogeneous graphene device in which the chemical exposure directly modulates an electrical carrier signal. To make the device ubiquitously reusable, a method of precisely tuning the charge neutrality point (Vcnp) is introduced by electrochemical calibration with gate voltage pulse sequence. Such chemically gated graphene modulator can be potentially used in a harmonic transponder as a passive ubiquitous sensor node for chemical and bio sensing applications. Overall the research work presented in the dissertation will help enable cost and power-efficient wireless sensor networks in future healthcare IoTs.Electrical and Computer Engineerin

Doctor of Philosophy

dissertationMicroelectromechanical systems (MEMS) resonators on Si have the potential to replace the discrete passive components in a power converter. The main intention of this dissertation is to present a ring-shaped aluminum nitride (AlN) piezoelectric microreson

Wireless Telemetry System for Implantable Sensors

Advanced testing of medical treatments involves experimentation on small laboratory animals, such as genetically modified mice. These subjects are used to help researchers develop medication and cures for humans. To understand the effects of the treatments, innovative telemetry systems are developed, that enable remote real-time cardiac monitoring. The latest research in the field of cardiac monitoring has revealed two major limitations with wireless implantable systems: a) the current size of implantable electronics limits the physical size of the system to larger subjects; and b) the systems only interface with one sensor type (e.g., pressure sensor only). This research focuses on the design of a wireless telemetry system architecture, intended to retrieve blood pressure and volume data. A physical prototype is created that is 2.475 cm3 and weights 4.01 g. This thesis will enable a path towards miniaturization, leading to the incorporation of a wireless system into small laboratory animals

Flexible, stretchable, and transient electronics for integration with the human body

Technologies capable of establishing intimate, long-lived interfaces to the human body have broad utility in continuous measurement of physiological status, with the potential to significantly lower tissue injury and irritation after implants. The development of such soft, biocompatible platforms and integrating them into a biotissue-interfaced system requires suitable choice of materials and engineered structures. Specific directions include overall miniaturization (e.g., Si nanomembrane) or composite material structure (e.g., carbon black doped elastomer) that provide effective mechanics to match those of biological tissues. This dissertation presents combined experimental and theoretical investigations of such functional systems that offer flexibility and stretchability, while maintaining operational performance and mechanical robustness. The dissertation begins with a fundamental study of responsive monocrystalline silicon nanomembrane as a flexible electromechanical sensor element. Subsequent chapters highlight integration with active components for wireless addressing, multiplexing, and local amplification, with multimodal operation in a thin, soft, skin-like platform. The resulting biointegrated system enables (1) sensitive health monitoring system, (2) multifunctional tactile sensor, (3) high-density neural interfaces, and (4) physically transient, implantable electronics, all with the capability of stable operation for long timeframes