Nonlinear quantile mixed models

In regression applications, the presence of nonlinearity and correlation among observations offer computational challenges not only in traditional settings such as least squares regression, but also (and especially) when the objective function is non-smooth as in the case of quantile regression. In this paper, we develop methods for the modeling and estimation of nonlinear conditional quantile functions when data are clustered within two-level nested designs. This work represents an extension of the linear quantile mixed models of Geraci and Bottai (2014, Statistics and Computing). We develop a novel algorithm which is a blend of a smoothing algorithm for quantile regression and a second order Laplacian approximation for nonlinear mixed models. To assess the proposed methods, we present a simulation study and two applications, one in pharmacokinetics and one related to growth curve modeling in agriculture.Comment: 26 pages, 8 figures, 8 table

Detection of risk factors for obesity in early childhood with quantile regression methods for longitudinal data

This article compares and discusses three different statistical methods for investigating risk factors for overweight and obesity in early childhood by means of the LISA study, a recent German birth cohort study with 3097 children. Since the definition of overweight and obesity is typically based on upper quantiles (90% and 97%) of the age specific body mass index (BMI) distribution, our aim was to model the influence of risk factors and age on these quantiles while as far as possible taking the longitudinal data structure into account. The following statistical regression models were chosen: additive mixed models, generalized additive models for location, scale and shape (GAMLSS), and distribution free quantile regression models. The methods were compared empirically by cross-validation and for the data at hand no model could be rated superior. Motivated by previous studies we explored whether there is an age-specific skewness of the BMI distribution. The investigated data does not suggest such an effect, even after adjusting for risk factors. Concerning risk factors, our results mainly confirm results obtained in previous studies. From a methodological point of view, we conclude that GAMLSS and distribution free quantile regression are promising approaches for longitudinal quantile regression, requiring, however, further extensions to fully account for longitudinal data structures

Instrumental variables quantile regression for panel data with measurement errors

This paper develops an instrumental variables estimator for quantile regression in panel data with fixed effects. Asymptotic properties of the instrumental variables estimator are studied for large N and T when Na/T ! 0, for some a > 0. Wald and Kolmogorov-Smirnov type tests for general linear restrictions are developed. The estimator is applied to the problem of measurement errors in variables, which induces endogeneity and as a result bias in the model. We derive an approximation to the bias in the quantile regression fixed effects estimator in the presence of measurement error and show its connection to similar effects in standard least squares models. Monte Carlo simulations are conducted to evaluate the finite sample properties of the estimator in terms of bias and root mean squared error. Finally, the methods are applied to a model of firm investment. The results show interesting heterogeneity in the Tobin’s q and cash flow sensitivities of investment. In both cases, the sensitivities are monotonically increasing along the quantiles

Estimating spatial quantile regression with functional coefficients: A robust semiparametric framework

This paper considers an estimation of semiparametric functional (varying)-coefficient quantile regression with spatial data. A general robust framework is developed that treats quantile regression for spatial data in a natural semiparametric way. The local M-estimators of the unknown functional-coefficient functions are proposed by using local linear approximation, and their asymptotic distributions are then established under weak spatial mixing conditions allowing the data processes to be either stationary or nonstationary with spatial trends. Application to a soil data set is demonstrated with interesting findings that go beyond traditional analysis.Comment: Published in at http://dx.doi.org/10.3150/12-BEJ480 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Partially linear censored quantile regression

Censored regression quantile (CRQ) methods provide a powerful and flexible approach to the analysis of censored survival data when standard linear models are felt to be appropriate. In many cases however, greater flexibility is desired to go beyond the usual multiple regression paradigm. One area of common interest is that of partially linear models: one (or more) of the explanatory covariates are assumed to act on the response through a non-linear function. Here the CRQ approach of Portnoy (J Am Stat Assoc 98:1001–1012, 2003) is extended to this partially linear setting. Basic consistency results are presented. A simulation experiment and unemployment example justify the value of the partially linear approach over methods based on the Cox proportional hazards model and on methods not permitting nonlinearity