Automatic head computed tomography image noise quantification with deep learning

Purpose: Computed tomography (CT) image noise is usually determined by standard deviation (SD) of pixel values from uniform image regions. This study investigates how deep learning (DL) could be applied in head CT image noise estimation.Methods: Two approaches were investigated for noise image estimation of a single acquisition image: direct noise image estimation using supervised DnCNN convolutional neural network (CNN) architecture, and subtraction of a denoised image estimated with denoising UNet-CNN experimented with supervised and unsupervised noise2noise training approaches. Noise was assessed with local SD maps using 3D- and 2D-CNN architectures. Anthropomorphic phantom CT image dataset (N = 9 scans, 3 repetitions) was used for DL-model comparisons. Mean square error (MSE) and mean absolute percentage errors (MAPE) of SD values were determined using the SD values of subtraction images as ground truth. Open-source clinical head CT low-dose dataset (N-train = 37, N-test( )= 10 subjects) were used to demonstrate DL applicability in noise estimation from manually labeled uniform regions and in automated noise and contrast assessment.Results: The direct SD estimation using 3D-CNN was the most accurate assessment method when comparing in phantom dataset (MAPE = 15.5%, MSE = 6.3HU). Unsupervised noise2noise approach provided only slightly inferior results (MAPE = 20.2%, MSE = 13.7HU). 2DCNN and unsupervised UNet models provided the smallest MSE on clinical labeled uniform regions.Conclusions: DL-based clinical image assessment is feasible and provides acceptable accuracy as compared to true image noise. Noise2noise approach may be feasible in clinical use where no ground truth data is available. Noise estimation combined with tissue segmentation may enable more comprehensive image quality characterization.Peer reviewe

Generalized signal-dependent noise model and parameter estimation for natural images

International audienceThe goal of this paper is to propose a generalized signal-dependent noise model that is more appropriate to describe a natural image acquired by a digital camera than the conventional Additive White Gaussian Noise model widely used in image processing.This non-linear noise model takes into account effects in the image acquisition pipeline of a digital camera. In this paper, an algorithm for estimation of noise model parameters from a single image is designed. Then the proposed noise model is applied with the Local Linear Minimum Mean Square Error filter to design an efficient image denoising method

1 Indirect estimation of signal-dependent noise with non-adaptive heterogeneous samples

Abstract—We consider the estimation of signal-dependent noise from a single image. Unlike conventional algorithms that build a scatterplot of local mean-variance pairs from either small or adaptively selected homogeneous data samples, our proposed approach relies on arbitrarily large patches of heterogeneous data extracted at random from the image. We demonstrate the feasibility of our approach through an extensive theoretical analysis based on mixture of Gaussian distributions. A prototype algorithm is also developed in order to validate the approach on simulated data as well as on real camera raw images. Index Terms—Noise estimation, signal-dependent noise, Poisson noise