Veni Vidi Vici, A Three-Phase Scenario For Parameter Space Analysis in Image Analysis and Visualization

Automatic analysis of the enormous sets of images is a critical task in life sciences. This faces many challenges such as: algorithms are highly parameterized, significant human input is intertwined, and lacking a standard meta-visualization approach. This paper proposes an alternative iterative approach for optimizing input parameters, saving time by minimizing the user involvement, and allowing for understanding the workflow of algorithms and discovering new ones. The main focus is on developing an interactive visualization technique that enables users to analyze the relationships between sampled input parameters and corresponding output. This technique is implemented as a prototype called Veni Vidi Vici, or "I came, I saw, I conquered." This strategy is inspired by the mathematical formulas of numbering computable functions and is developed atop ImageJ, a scientific image processing program. A case study is presented to investigate the proposed framework. Finally, the paper explores some potential future issues in the application of the proposed approach in parameter space analysis in visualization

Measuring charged current neutrino interactions in the electromagnetic calorimeters of the ND280 detector

This thesis presents a study of neutrino interactions within the electromagnetic calorimeters (ECals) of the Tokai-to-Kamioka (T2K) off -axis near detector (ND280), using data collected from T2K Run II and Run III. Neutrino oscillation physics is a rapidly advancing field, with the recent discovery of non-zero [Symbol appears here. To view, please open pdf attachment]13 allowing the possibility of measuring CP-violation in the lepton sector. The current neutrino beam experiments must make precise measurements of the oscillation parameters and to do this require an improved understanding of neutrino interactions, which can only come through better measurements of neutrino cross-sections. This thesis describes the development of a neutrino event selection using a boosted decision tree multi-variate analysis to separate interactions within the ND280 ECals from entering backgrounds. This is then used to provide a selection of neutrino event samples from each ECal module, which are inputs to a X2 fit that is used to extract the [Symbols appears here. To view, please open pdf attachment] charged current inclusive cross-section, which was found to be [Mathematical equation appears here. To view, please open pdf attachment].Open Acces

Robust Multiple Signal Classification via Probability Measure Transformation

In this paper, we introduce a new framework for robust multiple signal classification (MUSIC). The proposed framework, called robust measure-transformed (MT) MUSIC, is based on applying a transform to the probability distribution of the received signals, i.e., transformation of the probability measure defined on the observation space. In robust MT-MUSIC, the sample covariance is replaced by the empirical MT-covariance. By judicious choice of the transform we show that: 1) the resulting empirical MT-covariance is B-robust, with bounded influence function that takes negligible values for large norm outliers, and 2) under the assumption of spherically contoured noise distribution, the noise subspace can be determined from the eigendecomposition of the MT-covariance. Furthermore, we derive a new robust measure-transformed minimum description length (MDL) criterion for estimating the number of signals, and extend the MT-MUSIC framework to the case of coherent signals. The proposed approach is illustrated in simulation examples that show its advantages as compared to other robust MUSIC and MDL generalizations

A Modular Approach to Lung Nodule Detection from Computed Tomography Images Using Artificial Neural Networks and Content Based Image Representation

Lung cancer is one of the most lethal cancer types. Research in computer aided detection (CAD) and diagnosis for lung cancer aims at providing effective tools to assist physicians in cancer diagnosis and treatment to save lives. In this dissertation, we focus on developing a CAD framework for automated lung cancer nodule detection from 3D lung computed tomography (CT) images. Nodule detection is a challenging task that no machine intelligence can surpass human capability to date. In contrast, human recognition power is limited by vision capacity and may suffer from work overload and fatigue, whereas automated nodule detection systems can complement expert’s efforts to achieve better detection performance. The proposed CAD framework encompasses several desirable properties such as mimicking physicians by means of geometric multi-perspective analysis, computational efficiency, and the most importantly producing high performance in detection accuracy. As the central part of the framework, we develop a novel hierarchical modular decision engine implemented by Artificial Neural Networks. One advantage of this decision engine is that it supports the combination of spatial-level and feature-level information analysis in an efficient way. Our methodology overcomes some of the limitations of current lung nodule detection techniques by combining geometric multi-perspective analysis with global and local feature analysis. The proposed modular decision engine design is flexible to modifications in the decision modules; the engine structure can adopt the modifications without having to re-design the entire system. The engine can easily accommodate multi-learning scheme and parallel implementation so that each information type can be processed (in parallel) by the most adequate learning technique of its own. We have also developed a novel shape representation technique that is invariant under rigid-body transformation and we derived new features based on this shape representation for nodule detection. We implemented a prototype nodule detection system as a demonstration of the proposed framework. Experiments have been conducted to assess the performance of the proposed methodologies using real-world lung CT data. Several performance measures for detection accuracy are used in the assessment. The results show that the decision engine is able to classify patterns efficiently with very good classification performance