8,191 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Adaptive Online Sequential ELM for Concept Drift Tackling
A machine learning method needs to adapt to over time changes in the
environment. Such changes are known as concept drift. In this paper, we propose
concept drift tackling method as an enhancement of Online Sequential Extreme
Learning Machine (OS-ELM) and Constructive Enhancement OS-ELM (CEOS-ELM) by
adding adaptive capability for classification and regression problem. The
scheme is named as adaptive OS-ELM (AOS-ELM). It is a single classifier scheme
that works well to handle real drift, virtual drift, and hybrid drift. The
AOS-ELM also works well for sudden drift and recurrent context change type. The
scheme is a simple unified method implemented in simple lines of code. We
evaluated AOS-ELM on regression and classification problem by using concept
drift public data set (SEA and STAGGER) and other public data sets such as
MNIST, USPS, and IDS. Experiments show that our method gives higher kappa value
compared to the multiclassifier ELM ensemble. Even though AOS-ELM in practice
does not need hidden nodes increase, we address some issues related to the
increasing of the hidden nodes such as error condition and rank values. We
propose taking the rank of the pseudoinverse matrix as an indicator parameter
to detect underfitting condition.Comment: Hindawi Publishing. Computational Intelligence and Neuroscience
Volume 2016 (2016), Article ID 8091267, 17 pages Received 29 January 2016,
Accepted 17 May 2016. Special Issue on "Advances in Neural Networks and
Hybrid-Metaheuristics: Theory, Algorithms, and Novel Engineering
Applications". Academic Editor: Stefan Hauf
Evolving spiking neural networks for temporal pattern recognition in the presence of noise
Creative Commons - Attribution-NonCommercial-NoDerivs 3.0 United StatesNervous systems of biological organisms use temporal patterns of spikes to encode sensory input, but the mechanisms that underlie the recognition of such patterns are unclear. In the present work, we explore how networks of spiking neurons can be evolved to recognize temporal input patterns without being able to adjust signal conduction delays. We evolve the networks with GReaNs, an artificial life platform that encodes the topology of the network (and the weights of connections) in a fashion inspired by the encoding of gene regulatory networks in biological genomes. The number of computational nodes or connections is not limited in GReaNs, but here we limit the size of the networks to analyze the functioning of the networks and the effect of network size on the evolvability of robustness to noise. Our results show that even very small networks of spiking neurons can perform temporal pattern recognition in the presence of input noiseFinal Published versio
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