744 research outputs found
Characterizing neuromorphologic alterations with additive shape functionals
The complexity of a neuronal cell shape is known to be related to its
function. Specifically, among other indicators, a decreased complexity in the
dendritic trees of cortical pyramidal neurons has been associated with mental
retardation. In this paper we develop a procedure to address the
characterization of morphological changes induced in cultured neurons by
over-expressing a gene involved in mental retardation. Measures associated with
the multiscale connectivity, an additive image functional, are found to give a
reasonable separation criterion between two categories of cells. One category
consists of a control group and two transfected groups of neurons, and the
other, a class of cat ganglionary cells. The reported framework also identified
a trend towards lower complexity in one of the transfected groups. Such results
establish the suggested measures as an effective descriptors of cell shape
Classification of pathology in diabetic eye disease
Proliferative diabetic retinopathy is a complication of diabetes that can eventually lead to blindness. Early identification of this complication reduces the risk of blindness by initiating timely treatment. We report the utility of pattern analysis tools linked with a simple linear discriminant analysis that not only identifies new vessel growth in the retinal fundus but also localises the area of pathology. Ten fluorescein images were analysed using seven feature descriptors including area, perimeter, circularity, curvature, entropy, wavelet second moment and the correlation dimension. Our results indicate that traditional features such as area or perimeter measures of neovascularisation associated with proliferative retinopathy were not sensitive enough to detect early proliferative retinopathy (SNR = 0.76, 0.75 respectively). The wavelet second moment provided the best discrimination with a SNR of 1.17. Combining second moment, curvature and global correlation dimension provided a 100% discrimination (SNR = 1)
Multiscale Geometric Methods for Data Sets II: Geometric Multi-Resolution Analysis
Data sets are often modeled as point clouds in , for large. It is
often assumed that the data has some interesting low-dimensional structure, for
example that of a -dimensional manifold , with much smaller than .
When is simply a linear subspace, one may exploit this assumption for
encoding efficiently the data by projecting onto a dictionary of vectors in
(for example found by SVD), at a cost for data points. When
is nonlinear, there are no "explicit" constructions of dictionaries that
achieve a similar efficiency: typically one uses either random dictionaries, or
dictionaries obtained by black-box optimization. In this paper we construct
data-dependent multi-scale dictionaries that aim at efficient encoding and
manipulating of the data. Their construction is fast, and so are the algorithms
that map data points to dictionary coefficients and vice versa. In addition,
data points are guaranteed to have a sparse representation in terms of the
dictionary. We think of dictionaries as the analogue of wavelets, but for
approximating point clouds rather than functions.Comment: Re-formatted using AMS styl
Medical image enhancement
Each image acquired from a medical imaging system is often part of a two-dimensional (2-D) image set whose total presents a three-dimensional (3-D) object for diagnosis. Unfortunately, sometimes these images are of poor quality. These distortions cause an inadequate object-of-interest presentation, which can result in inaccurate image analysis. Blurring is considered a serious problem. Therefore, ādeblurringā an image to obtain better quality is an important issue in medical image processing. In our research, the image is initially decomposed. Contrast improvement is achieved by modifying the coefficients obtained from the decomposed image. Small coefficient values represent subtle details and are amplified to improve the visibility of the corresponding details. The stronger image density variations make a major contribution to the overall dynamic range, and have large coefficient values. These values can be reduced without much information loss
Coarse Graining of Data via Inhomogeneous Diffusion Condensation
Big data often has emergent structure that exists at multiple levels of
abstraction, which are useful for characterizing complex interactions and
dynamics of the observations. Here, we consider multiple levels of abstraction
via a multiresolution geometry of data points at different granularities. To
construct this geometry we define a time-inhomogeneous diffusion process that
effectively condenses data points together to uncover nested groupings at
larger and larger granularities. This inhomogeneous process creates a deep
cascade of intrinsic low pass filters on the data affinity graph that are
applied in sequence to gradually eliminate local variability while adjusting
the learned data geometry to increasingly coarser resolutions. We provide
visualizations to exhibit our method as a continuously-hierarchical clustering
with directions of eliminated variation highlighted at each step. The utility
of our algorithm is demonstrated via neuronal data condensation, where the
constructed multiresolution data geometry uncovers the organization, grouping,
and connectivity between neurons.Comment: 14 pages, 7 figure
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