Synthesis of multifunctional nanoparticles for imaging and enhancement in therapy

The purpose of this work was to synthesize nanoparticles composed of high atomic number elements and semiconductor material in a core/shell structure for the potential to be used as enhancers for radiotherapy as well as luminescence imaging platforms. Additionally, to quantify their role in free radical production after exposure to ionizing radiation through chemical routes. Spherical gold nanoparticles were synthesized via a citrate stabilizer method. Two sizes of 12nm and 25 nm gold spheres were used as the cores for the europium-doped gadolinium vanadate flower-shaped shell. The production of 7-hydroxycoumarin-3-carboxylic acid in an aqueous environment upon kV irradiation of its precursor, coumarin-3-carboxylic acid, was assessed and used as a fluorescence detector for hydroxyl radicals. The quantification of excess or moderation of hydroxyl radicals in the presence of the nanomaterial as compared to a control sample can indicate the potential for increased DNA damage for purposes such as tumor control. This work indicates the potential for physical and chemical enhancement in the presence of nanomaterials

High-efficiency generation of nanomaterials via laser ablation synthesis in solution with in-situ diagnostics for closed-loop control

Driven by an ever-increasing demand for nanomaterials with specific functionalities, physical synthesis techniques such as Laser Ablation Synthesis in Solution (LASiS) have gained significant interest over in recent years. Commercial wet chemical synthesis methods, while having significantly higher nanomaterial yields than LASiS, typically have considerable negative environmental impact through the use of harmful reagents and solvents. LASiS therefore represents a route towards the sustainable “green” production of nanomaterials however the significant challenge to its commercialization is that of comparably low nanomaterial yields. Significant effort has been made towards increasing the production rates of LASiS, however many of the reported advances have relied on the use of high power (>20 W) or short pulse (<10 ps) laser systems which have high capital costs. Other advances have examined moving from batch production in small volumes towards the use of continuous production through the use of solvent flow systems. Combining these advances, we have developed a new system for nanomaterial generation via LASiS incorporating a low cost, low power (< 4W) Nd:YAG laser and solvent flow system for high-efficiency nanomaterial generation. This study has shown an increase in productivity from 2.5± 0.5 mg/hr for an 11 mL batch colloid, to continuous production yields of 17± 0.7 mg/hr under flow conditions

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations

Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibril formation of amyloid-prone proteins. We employ classical molecular dynamics simulations and large-scale density functional theory calculations to investigate the effects of nanomaterials on the structure, dynamics and binding of an amyloidogenic peptide apoC-II(60-70). We show that the binding affinity of this peptide to carbonaceous nanomaterials such as C60, nanotubes and graphene decreases with increasing nanoparticle curvature. Strong binding is facilitated by the large contact area available for π-stacking between the aromatic residues of the peptide and the extended surfaces of graphene and the nanotube. The highly curved fullerene surface exhibits reduced efficiency for π-stacking but promotes increased peptide dynamics. We postulate that the increase in conformational dynamics of the amyloid peptide can be unfavorable for the formation of fibril competent structures. In contrast, extended fibril forming peptide conformations are promoted by the nanotube and graphene surfaces which can provide a template for fibril-growth

An easily prepared graphene oxide-ionic liquid hybrid nanomaterial for micro-solid phase extraction and preconcentration of Hg in water samples

A preconcentration method based on the use of graphene oxide (GO) functionalized with an ionic liquid (IL) was developed for trace Hg determination in water samples. The IL-GO hybrid nanomaterial was prepared by a simple procedure to functionalize GO with the IL 1-butyl-3-dodecylimidazolium bromide ([C4C12im]Br) and its performance as a sorption material for Hg was evaluated. A microcolumn filled with the IL-GO nanomaterial was used for preconcentration and determination of Hg followed by electrothermal atomic absorption spectrometry (ETAAS) detection. Mercury was retained at pH 5.0 and 20% (v/v) HNO3 was used for the elution of Hg from the microcolumn. The effects of different variables, including the sample volume, extraction time, sample flow rate, type and concentration of eluent and eluent flow rate were carefully studied. High retention efficiency (100%) was achieved with the proposed IL-GO sorption nanomaterial without the need for additional chelating reagents or derivatization reagents, which is an important advantage compared with traditional preconcentration methods. A sensitivity enhancement factor of 100 and a low detection limit of 14 ng L-1 were obtained under optimal experimental conditions. The proposed method can be considered as a simple, cost-effective and efficient alternative for Hg determination in water samples like river, rain, mineral and tap water.Fil: Cruz Sotolongo, Annaly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Martinis, Estefanía Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Wuilloud, Rodolfo German. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo; Argentin

A Targeted Approach to High-Volume Fly Ash Concrete Pavement (Phase I)

Unlike the conventional method of admixing nanomaterials directly in fresh concrete mixture, a more targeted approach was explored. Specifically, nanomaterials were used to improve the interface between coarse aggregate and cement paste, by coating the coarse aggregate with cement paste that contained graphene oxide or nanosilica. Using coated coarse aggregates, the mechanical and transport properties of high-volume fly ash (HVFA) concrete were tested to evaluate the effect of nanomaterial coating on the interface transition zone of concrete. The compressive and splitting strengths of HVFA concrete at 3, 7, 14, and 28 days and the water sorptivity and chloride migration coefficient at 28 days were studied. Results show that nanomaterial-coated coarse aggregate can improve the transport properties of HVFA concrete by reducing permeability. However, no improvement was seen in the compressive and splitting strengths when incorporating coated coarse aggregate, compared with direct mixing of nanomaterials in fresh concrete. Resistance to freezing/thawing cycles and scanning electron microscope/energy dispersive X-ray spectroscopy of concrete samples were also investigated to obtain a more comprehensive and mechanistic understanding of nanomaterial coating

Effect of nanomaterial properties on thermal conductivity of heat transfer fluids and nanomaterial suspension

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Energy has been rated as the single most important issue facing humanity in the current as well as next 50 years. Securing clean energy has become the top priority of most developed countries. Considering the rapid increase in energy demand worldwide, intensifying the heat transfer process and reducing energy loss due to ineffective use have become an increasingly important task. Fundamentally, energy conversion and transportation occur at atomic or molecular levels, Nanoscience and nanotechnology are expected to play a significant role in revitalizing the traditional energy industries and stimulating the emerging renewable energy industries. Nanofluid is a modern engineering heat transfer fluid with superior potential for enhancing the heat transfer performance of conventional fluids such as water, ethylene glycol and oils. It is consisting of solid nanoparticles with sizes typically of 1–100 nm suspended in base fluids. Many attempts have been made to investigate its important thermal properties, i.e. thermal conductivity; however, no definitive agreements and idea have emerged about this property. This article reports the effect of different nanomaterial on the thermal conductivity enhancement of nanofluids experimentally. TiO2, Fe3O4 and Al2O3 nanoparticles dispersed in water and ethylene glycol with volume concentration of 1 – 7.5 vol. % is used in the present study. A transient hot-wire apparatus (KD2 pro) is used for measuring the thermal conductivity of nanofluids. The results show that all the heat transfer fluids show an increase in thermal conductivity with the addition of nanoparticles in it. The measured thermal conductivity of nanofluids increased as the particle concentrations increased and are higher than the values of the base liquids. This confirms the effect of volume concentration of nanoparticles on the thermal conductivity enhancement

Co-exposure of the organic nanomaterial fullerene C60 with benzo[a]pyrene in Danio rerio (zebrafish) hepatocytes: Evidence of toxicological interactions

Compounds from the nanotechnology industry, such as carbon-based nanomaterials, are strong candidates to contaminate aquatic environments because their production and disposal have exponentially grown in a few years. Previous evidence shows that fullerene C60, a carbon nanomaterial, can facilitate the intake of metals or PAHs both in vivo and in vitro, potentially amplifying the deleterious effects of these toxicants in organisms. The present work aimed to investigate the effects of fullerene C60 in a Danio rerio (zebrafish) hepatocyte cell lineage exposed to benzo[a]pyrene (BaP) in terms of cell viability, oxidative stress parameters and BaP intracellular accumulation. Additionally, a computational docking was performed to investigate the interaction of the fullerene C60 molecule with the detoxificatory and antioxidant enzyme πGST. Fullerene C60 provoked a significant (p 0.05) alter the enzyme activity when added to GST purified extracts from the zebrafish hepatocyte cells. These results show that fullerene C60 can increase the intake of BaP into the cells, decreasing cell viability and impairing the detoxificatory response by phase II enzymes, such as GST, and this latter effect should be occurring at the transcriptional level.Fil: Ribas Ferreira, Josencler L.. Universidade Federal do Rio Grande do Sul; BrasilFil: Lonné, María Noelia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: França, Thiago A.. Universidade Federal do Rio Grande do Sul; BrasilFil: Maximilla, Naiana R.. Universidade Federal do Rio Grande do Sul; BrasilFil: Lugokenski, Thiago H.. Universidade Federal de Santa Maria. Departamento de Química; BrasilFil: Costa, Patrícia G.. Universidade Federal do Rio Grande do Sul; BrasilFil: Fillmann, Gilberto. Universidade Federal do Rio Grande do Sul; BrasilFil: Soares, Félix A.. Universidade Federal de Santa Maria. Departamento de Química; BrasilFil: de la Torre, Fernando Roman. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaFil: Monserrat, José María. Universidade Federal do Rio Grande do Sul; Brasil. Instituto Nacional de Ciência e Tecnologia de Nanomateriais de Carbono; Brasi

Transient Photoconductivity of a Thermoelectric Nanomaterial PEDOT:PSS with TeCu nanowires

Thermoelectric materials are able to transfer heat energy into electrical energy. They have many important applications, and an increased understanding of them would allow the scientific community to develop more efficient thermoelectrics. We provide here transient photoconductivity measurements of a thermoelectric nanomaterial - PEDOT:PSS with TeCu nanowires on quartz substrate. Increased copper concentration in nanowires decreases photoconductivity in both transmission and reflectance measurements. Fermi blocking provides a reasonable explanation for this decrease in photoconductivity, which occurs when total nanowire mass approaches ~15% copper concentration