End-to-End Fovea Localisation in Colour Fundus Images with a Hierarchical Deep Regression Network

Accurately locating the fovea is a prerequisite for developing computer aided diagnosis (CAD) of retinal diseases. In colour fundus images of the retina, the fovea is a fuzzy region lacking prominent visual features and this makes it difficult to directly locate the fovea. While traditional methods rely on explicitly extracting image features from the surrounding structures such as the optic disc and various vessels to infer the position of the fovea, deep learning based regression technique can implicitly model the relation between the fovea and other nearby anatomical structures to determine the location of the fovea in an end-to-end fashion. Although promising, using deep learning for fovea localisation also has many unsolved challenges. In this paper, we present a new end-to-end fovea localisation method based on a hierarchical coarse-to-fine deep regression neural network. The innovative features of the new method include a multi-scale feature fusion technique and a self-attention technique to exploit location, semantic, and contextual information in an integrated framework, a multi-field-of-view (multi-FOV) feature fusion technique for context-aware feature learning and a Gaussian-shiftcropping method for augmenting effective training data. We present extensive experimental results on two public databases and show that our new method achieved state of- the-art performances. We also present a comprehensive ablation study and analysis to demonstrate the technical soundness and effectiveness of the overall framework and its various constituent components

Bilateral-Fuser: A Novel Multi-cue Fusion Architecture with Anatomical-aware Tokens for Fovea Localization

Accurate localization of fovea is one of the primary steps in analyzing retinal diseases since it helps prevent irreversible vision loss. Although current deep learning-based methods achieve better performance than traditional methods, there still remain challenges such as utilizing anatomical landmarks insufficiently, sensitivity to diseased retinal images and various image conditions. In this paper, we propose a novel transformer-based architecture (Bilateral-Fuser) for multi-cue fusion. This architecture explicitly incorporates long-range connections and global features using retina and vessel distributions for robust fovea localization. We introduce a spatial attention mechanism in the dual-stream encoder for extracting and fusing self-learned anatomical information. This design focuses more on features distributed along blood vessels and significantly decreases computational costs by reducing token numbers. Our comprehensive experiments show that the proposed architecture achieves state-of-the-art performance on two public and one large-scale private datasets. We also present that the Bilateral-Fuser is more robust on both normal and diseased retina images and has better generalization capacity in cross-dataset experiments.Comment: This paper is prepared for IEEE TRANSACTIONS ON MEDICAL IMAGIN

Open Source Software for Automatic Detection of Cone Photoreceptors in Adaptive Optics Ophthalmoscopy Using Convolutional Neural Networks

Imaging with an adaptive optics scanning light ophthalmoscope (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina. Quantitative analysis of AOSLO images typically requires manual grading, which is time consuming, and subjective; thus, automated algorithms are highly desirable. Previously developed automated methods are often reliant on ad hoc rules that may not be transferable between different imaging modalities or retinal locations. In this work, we present a convolutional neural network (CNN) based method for cone detection that learns features of interest directly from training data. This cone-identifying algorithm was trained and validated on separate data sets of confocal and split detector AOSLO images with results showing performance that closely mimics the gold standard manual process. Further, without any need for algorithmic modifications for a specific AOSLO imaging system, our fully-automated multi-modality CNN-based cone detection method resulted in comparable results to previous automatic cone segmentation methods which utilized ad hoc rules for different applications. We have made free open-source software for the proposed method and the corresponding training and testing datasets available online