Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis

This paper presents an alternative method, called as parallel factor analysis (PARAFAC) with a continuous wavelet transform, to analyze of brain activity in patients with chronic pain in the time-frequency-channel domain and quantifies differences between chronic pain patients and controls in these domains. The event related multiple EEG recordings of the chronic pain patients and non-pain controls with somatosensory stimuli (pain, random pain, touch, random touch) are analyzed. Multiple linear regression (MLR) is applied to describe the effects of aging on the frequency response differences between patients and controls. The results show that the somatosensory cortical responses occurred around 250 ms in both groups. In the frequency domain, the neural response frequency in the pain group (around 4 Hz) was less than that in the control group (around 5.5 Hz) under the somatosensory stimuli. In the channel domain, cortical activation was predominant in the frontal region for the chronic pain group and in the central region for controls. The indices of active ratios were statistical significant between the two groups in the frontal and central regions. These findings demonstrate that the PARAFAC is an interesting method to understanding the pathophysiological characteristics of chronic pain

Advanced tensor based signal processing techniques for wireless communication systems and biomedical signal processing

Many observed signals in signal processing applications including wireless communications, biomedical signal processing, image processing, and machine learning are multi-dimensional. Tensors preserve the multi-dimensional structure and provide a natural representation of these signals/data. Moreover, tensors provide often an improved identifiability. Therefore, we benefit from using tensor algebra in the above mentioned applications and many more. In this thesis, we present the benefits of utilizing tensor algebra in two signal processing areas. These include signal processing for MIMO (Multiple-Input Multiple-Output) wireless communication systems and biomedical signal processing. Moreover, we contribute to the theoretical aspects of tensor algebra by deriving new properties and ways of computing tensor decompositions. Often, we only have an element-wise or a slice-wise description of the signal model. This representation of the signal model does not reveal the explicit tensor structure. Therefore, the derivation of all tensor unfoldings is not always obvious. Consequently, exploiting the multi-dimensional structure of these models is not always straightforward. We propose an alternative representation of the element-wise multiplication or the slice-wise multiplication based on the generalized tensor contraction operator. Later in this thesis, we exploit this novel representation and the properties of the contraction operator such that we derive the final tensor models. There exist a number of different tensor decompositions that describe different signal models such as the HOSVD (Higher Order Singular Value Decomposition), the CP/PARAFAC (Canonical Polyadic / PARallel FACtors) decomposition, the BTD (Block Term Decomposition), the PARATUCK2 (PARAfac and TUCker2) decomposition, and the PARAFAC2 (PARAllel FACtors2) decomposition. Among these decompositions, the CP decomposition is most widely spread and used. Therefore, the development of algorithms for the efficient computation of the CP decomposition is important for many applications. The SECSI (Semi-Algebraic framework for approximate CP decomposition via SImultaneaous matrix diagonalization) framework is an efficient and robust tool for the calculation of the approximate low-rank CP decomposition via simultaneous matrix diagonalizations. In this thesis, we present five extensions of the SECSI framework that reduce the computational complexity of the original framework and/or introduce constraints to the factor matrices. Moreover, the PARAFAC2 decomposition and the PARATUCK2 decomposition are usually described using a slice-wise notation that can be expressed in terms of the generalized tensor contraction as proposed in this thesis. We exploit this novel representation to derive explicit tensor models for the PARAFAC2 decomposition and the PARATUCK2 decomposition. Furthermore, we use the PARAFAC2 model to derive an ALS (Alternating Least-Squares) algorithm for the computation of the PARAFAC2 decomposition. Moreover, we exploit the novel contraction properties for element wise and slice-wise multiplications to model MIMO multi-carrier wireless communication systems. We show that this very general model can be used to derive the tensor model of the received signal for MIMO-OFDM (Multiple-Input Multiple-Output - Orthogonal Frequency Division Multiplexing), Khatri-Rao coded MIMO-OFDM, and randomly coded MIMO-OFDM systems. We propose the transmission techniques Khatri-Rao coding and random coding in order to impose an additional tensor structure of the transmit signal tensor that otherwise does not have a particular structure. Moreover, we show that this model can be extended to other multi-carrier techniques such as GFDM (Generalized Frequency Division Multiplexing). Utilizing these models at the receiver side, we design several types for receivers for these systems that outperform the traditional matrix based solutions in terms of the symbol error rate. In the last part of this thesis, we show the benefits of using tensor algebra in biomedical signal processing by jointly decomposing EEG (ElectroEncephaloGraphy) and MEG (MagnetoEncephaloGraphy) signals. EEG and MEG signals are usually acquired simultaneously, and they capture aspects of the same brain activity. Therefore, EEG and MEG signals can be decomposed using coupled tensor decompositions such as the coupled CP decomposition. We exploit the proposed coupled SECSI framework (one of the proposed extensions of the SECSI framework) for the computation of the coupled CP decomposition to first validate and analyze the photic driving effect. Moreover, we validate the effects of scull defects on the measurement EEG and MEG signals by means of a joint EEG-MEG decomposition using the coupled SECSI framework. Both applications show that we benefit from coupled tensor decompositions and the coupled SECSI framework is a very practical tool for the analysis of biomedical data.Zahlreiche messbare Signale in verschiedenen Bereichen der digitalen Signalverarbeitung, z.B. in der drahtlosen Kommunikation, im Mobilfunk, biomedizinischen Anwendungen, der Bild- oder akustischen Signalverarbeitung und dem maschinellen Lernen sind mehrdimensional. Tensoren erhalten die mehrdimensionale Struktur und stellen eine natürliche Darstellung dieser Signale/Daten dar. Darüber hinaus bieten Tensoren oft eine verbesserte Trennbarkeit von enthaltenen Signalkomponenten. Daher profitieren wir von der Verwendung der Tensor-Algebra in den oben genannten Anwendungen und vielen mehr. In dieser Arbeit stellen wir die Vorteile der Nutzung der Tensor-Algebra in zwei Bereichen der Signalverarbeitung vor: drahtlose MIMO (Multiple-Input Multiple-Output) Kommunikationssysteme und biomedizinische Signalverarbeitung. Darüber hinaus tragen wir zu theoretischen Aspekten der Tensor-Algebra bei, indem wir neue Eigenschaften und Berechnungsmethoden für die Tensor-Zerlegung ableiten. Oftmals verfügen wir lediglich über eine elementweise oder ebenenweise Beschreibung des Signalmodells, welche nicht die explizite Tensorstruktur zeigt. Daher ist die Ableitung aller Tensor-Unfoldings nicht offensichtlich, wodurch die multidimensionale Struktur dieser Modelle nicht trivial nutzbar ist. Wir schlagen eine alternative Darstellung der elementweisen Multiplikation oder der ebenenweisen Multiplikation auf der Grundlage des generalisierten Tensor-Kontraktionsoperators vor. Weiterhin nutzen wir diese neuartige Darstellung und deren Eigenschaften zur Ableitung der letztendlichen Tensor-Modelle. Es existieren eine Vielzahl von Tensor-Zerlegungen, die verschiedene Signalmodelle beschreiben, wie die HOSVD (Higher Order Singular Value Decomposition), CP/PARAFAC (Canonical Polyadic/ PARallel FACtors) Zerlegung, die BTD (Block Term Decomposition), die PARATUCK2-(PARAfac und TUCker2) und die PARAFAC2-Zerlegung (PARAllel FACtors2). Dabei ist die CP-Zerlegung am weitesten verbreitet und wird findet in zahlreichen Gebieten Anwendung. Daher ist die Entwicklung von Algorithmen zur effizienten Berechnung der CP-Zerlegung von besonderer Bedeutung. Das SECSI (Semi-Algebraic Framework for approximate CP decomposition via Simultaneaous matrix diagonalization) Framework ist ein effizientes und robustes Werkzeug zur Berechnung der approximierten Low-Rank CP-Zerlegung durch simultane Matrixdiagonalisierung. In dieser Arbeit stellen wir fünf Erweiterungen des SECSI-Frameworks vor, welche die Rechenkomplexität des ursprünglichen Frameworks reduzieren bzw. Einschränkungen für die Faktormatrizen einführen. Darüber hinaus werden die PARAFAC2- und die PARATUCK2-Zerlegung in der Regel mit einer ebenenweisen Notation beschrieben, die sich in Form der allgemeinen Tensor-Kontraktion, wie sie in dieser Arbeit vorgeschlagen wird, ausdrücken lässt. Wir nutzen diese neuartige Darstellung, um explizite Tensormodelle für diese beiden Zerlegungen abzuleiten. Darüber hinaus verwenden wir das PARAFAC2-Modell, um einen ALS-Algorithmus (Alternating Least-Squares) für die Berechnung der PARAFAC2-Zerlegungen abzuleiten. Weiterhin nutzen wir die neuartigen Kontraktionseigenschaften für elementweise und ebenenweise Multiplikationen, um MIMO Multi-Carrier-Mobilfunksysteme zu modellieren. Wir zeigen, dass dieses sehr allgemeine Modell verwendet werden kann, um das Tensor-Modell des empfangenen Signals für MIMO-OFDM- (Multiple- Input Multiple-Output - Orthogonal Frequency Division Multiplexing), Khatri-Rao codierte MIMO-OFDM- und zufällig codierte MIMO-OFDM-Systeme abzuleiten. Wir schlagen die Übertragungstechniken der Khatri-Rao-Kodierung und zufällige Kodierung vor, um eine zusätzliche Tensor-Struktur des Sendesignal-Tensors einzuführen, welcher gewöhnlich keine bestimmte Struktur aufweist. Darüber hinaus zeigen wir, dass dieses Modell auf andere Multi-Carrier-Techniken wie GFDM (Generalized Frequency Division Multiplexing) erweitert werden kann. Unter Verwendung dieser Modelle auf der Empfängerseite entwerfen wir verschiedene Typen von Empfängern für diese Systeme, die die traditionellen matrixbasierten Lösungen in Bezug auf die Symbolfehlerrate übertreffen. Im letzten Teil dieser Arbeit zeigen wir die Vorteile der Verwendung von Tensor-Algebra in der biomedizinischen Signalverarbeitung durch die gemeinsame Zerlegung von EEG-(ElectroEncephaloGraphy) und MEG- (MagnetoEncephaloGraphy) Signalen. Diese werden in der Regel gleichzeitig erfasst, wobei sie gemeinsame Aspekte derselben Gehirnaktivität beschreiben. Daher können EEG- und MEG-Signale mit gekoppelten Tensor-Zerlegungen wie der gekoppelten CP Zerlegung analysiert werden. Wir nutzen das vorgeschlagene gekoppelte SECSI-Framework (eine der vorgeschlagenen Erweiterungen des SECSI-Frameworks) für die Berechnung der gekoppelten CP Zerlegung, um zunächst den photic driving effect zu validieren und zu analysieren. Darüber hinaus validieren wir die Auswirkungen von Schädeldefekten auf die Messsignale von EEG und MEG durch eine gemeinsame EEG-MEG-Zerlegung mit dem gekoppelten SECSI-Framework. Beide Anwendungen zeigen, dass wir von gekoppelten Tensor-Zerlegungen profitieren, wobei die Methoden des gekoppelten SECSI-Frameworks erfolgreich zur Analyse biomedizinischer Daten genutzt werden können

Blind Multilinear Identification

We discuss a technique that allows blind recovery of signals or blind identification of mixtures in instances where such recovery or identification were previously thought to be impossible: (i) closely located or highly correlated sources in antenna array processing, (ii) highly correlated spreading codes in CDMA radio communication, (iii) nearly dependent spectra in fluorescent spectroscopy. This has important implications --- in the case of antenna array processing, it allows for joint localization and extraction of multiple sources from the measurement of a noisy mixture recorded on multiple sensors in an entirely deterministic manner. In the case of CDMA, it allows the possibility of having a number of users larger than the spreading gain. In the case of fluorescent spectroscopy, it allows for detection of nearly identical chemical constituents. The proposed technique involves the solution of a bounded coherence low-rank multilinear approximation problem. We show that bounded coherence allows us to establish existence and uniqueness of the recovered solution. We will provide some statistical motivation for the approximation problem and discuss greedy approximation bounds. To provide the theoretical underpinnings for this technique, we develop a corresponding theory of sparse separable decompositions of functions, including notions of rank and nuclear norm that specialize to the usual ones for matrices and operators but apply to also hypermatrices and tensors.Comment: 20 pages, to appear in IEEE Transactions on Information Theor

Brain signal analysis in space-time-frequency domain : an application to brain computer interfacing

In this dissertation, advanced methods for electroencephalogram (EEG) signal analysis in the space-time-frequency (STF) domain with applications to eye-blink (EB) artifact removal and brain computer interfacing (BCI) are developed. The two methods for EB artifact removal from EEGs are presented which respectively include the estimated spatial signatures of the EB artifacts into the signal extraction and the robust beamforming frameworks. In the developed signal extraction algorithm, the EB artifacts are extracted as uncorrelated signals from EEGs. The algorithm utilizes the spatial signatures of the EB artifacts as priori knowledge in the signal extraction stage. The spatial distributions are identified using the STF model of EEGs. In the robust beamforming approach, first a novel space-time-frequency/time-segment (STF-TS) model for EEGs is introduced. The estimated spatial signatures of the EBs are then taken into account in order to restore the artifact contaminated EEG measurements. Both algorithms are evaluated by using the simulated and real EEGs and shown to produce comparable results to that of conventional approaches. Finally, an effective paradigm for BCI is introduced. In this approach prior physiological knowledge of spectrally band limited steady-state movement related potentials is exploited. The results consolidate the method.EThOS - Electronic Theses Online ServiceGBUnited Kingdo