Backtracking Spatial Pyramid Pooling (SPP)-based Image Classifier for Weakly Supervised Top-down Salient Object Detection

Top-down saliency models produce a probability map that peaks at target locations specified by a task/goal such as object detection. They are usually trained in a fully supervised setting involving pixel-level annotations of objects. We propose a weakly supervised top-down saliency framework using only binary labels that indicate the presence/absence of an object in an image. First, the probabilistic contribution of each image region to the confidence of a CNN-based image classifier is computed through a backtracking strategy to produce top-down saliency. From a set of saliency maps of an image produced by fast bottom-up saliency approaches, we select the best saliency map suitable for the top-down task. The selected bottom-up saliency map is combined with the top-down saliency map. Features having high combined saliency are used to train a linear SVM classifier to estimate feature saliency. This is integrated with combined saliency and further refined through a multi-scale superpixel-averaging of saliency map. We evaluate the performance of the proposed weakly supervised topdown saliency and achieve comparable performance with fully supervised approaches. Experiments are carried out on seven challenging datasets and quantitative results are compared with 40 closely related approaches across 4 different applications.Comment: 14 pages, 7 figure

Systematic analysis of primary sequence domain segments for the discrimination between class C GPCR subtypes

G-protein-coupled receptors (GPCRs) are a large and diverse super-family of eukaryotic cell membrane proteins that play an important physiological role as transmitters of extracellular signal. In this paper, we investigate Class C, a member of this super-family that has attracted much attention in pharmacology. The limited knowledge about the complete 3D crystal structure of Class C receptors makes necessary the use of their primary amino acid sequences for analytical purposes. Here, we provide a systematic analysis of distinct receptor sequence segments with regard to their ability to differentiate between seven class C GPCR subtypes according to their topological location in the extracellular, transmembrane, or intracellular domains. We build on the results from the previous research that provided preliminary evidence of the potential use of separated domains of complete class C GPCR sequences as the basis for subtype classification. The use of the extracellular N-terminus domain alone was shown to result in a minor decrease in subtype discrimination in comparison with the complete sequence, despite discarding much of the sequence information. In this paper, we describe the use of Support Vector Machine-based classification models to evaluate the subtype-discriminating capacity of the specific topological sequence segments.Peer ReviewedPostprint (author's final draft