From Personalized Medicine to Population Health: A Survey of mHealth Sensing Techniques

Mobile Sensing Apps have been widely used as a practical approach to collect behavioral and health-related information from individuals and provide timely intervention to promote health and well-beings, such as mental health and chronic cares. As the objectives of mobile sensing could be either \emph{(a) personalized medicine for individuals} or \emph{(b) public health for populations}, in this work we review the design of these mobile sensing apps, and propose to categorize the design of these apps/systems in two paradigms -- \emph{(i) Personal Sensing} and \emph{(ii) Crowd Sensing} paradigms. While both sensing paradigms might incorporate with common ubiquitous sensing technologies, such as wearable sensors, mobility monitoring, mobile data offloading, and/or cloud-based data analytics to collect and process sensing data from individuals, we present a novel taxonomy system with two major components that can specify and classify apps/systems from aspects of the life-cycle of mHealth Sensing: \emph{(1) Sensing Task Creation \& Participation}, \emph{(2) Health Surveillance \& Data Collection}, and \emph{(3) Data Analysis \& Knowledge Discovery}. With respect to different goals of the two paradigms, this work systematically reviews this field, and summarizes the design of typical apps/systems in the view of the configurations and interactions between these two components. In addition to summarization, the proposed taxonomy system also helps figure out the potential directions of mobile sensing for health from both personalized medicines and population health perspectives.Comment: Submitted to a journal for revie

Privacy and Security in Mobile Health – a Research Agenda

Mobile health technology has great potential to increase healthcare quality, expand access to services, reduce costs, and improve personal wellness and public health. However, mHealth also raises significant privacy and security challenges

cii Student Papers - 2021

In this collection of papers, we, the Research Group Critical Information Infrastructures (cii) from the Karlsruhe Institute of Technology, present nine selected student research articles contributing to the design, development, and evaluation of critical information infrastructures. During our courses, students mostly work in groups and deal with problems and issues related to sociotechnical challenges in the realm of (critical) information systems. Student papers came from four different cii courses, namely Emerging Trends in Digital Health, Emerging Trends in Internet Technologies, Critical Information Infrastructures, and Digital Health in the winter term of 2020 and summer term of 2021

Cyber risk in health facilities: A systematic literature review

The current world challenges include issues such as infectious disease pandemics, environmental health risks, food safety, and crime prevention. Through this article, a special emphasis is given to one of the main challenges in the healthcare sector during the COVID-19 pandemic, the cyber risk. Since the beginning of the Covid-19 pandemic, the World Health Organization has detected a dramatic increase in the number of cyber-attacks. For instance, in Italy the COVID-19 emergency has heavily affected cybersecurity; from January to April 2020, the total of attacks, accidents, and violations of privacy to the detriment of companies and individuals has doubled. Using a systematic and rigorous approach, this paper aims to analyze the literature on the cyber risk in the healthcare sector to understand the real knowledge on this topic. The findings highlight the poor attention of the scientific community on this topic, except in the United States. The literature lacks research contributions to support cyber risk management in subject areas such as Business, Management and Accounting; Social Science; and Mathematics. This research outlines the need to empirically investigate the cyber risk, giving a practical solution to health facilities. Keywords: cyber risk; cyber-attack; cybersecurity; computer security; COVID-19; coronavirus;information technology risk; risk management; risk assessment; health facilities; healthcare sector;systematic literature review; insuranc

Toward Data-Driven Digital Therapeutics Analytics: Literature Review and Research Directions

With the advent of Digital Therapeutics (DTx), the development of software as a medical device (SaMD) for mobile and wearable devices has gained significant attention in recent years. Existing DTx evaluations, such as randomized clinical trials, mostly focus on verifying the effectiveness of DTx products. To acquire a deeper understanding of DTx engagement and behavioral adherence, beyond efficacy, a large amount of contextual and interaction data from mobile and wearable devices during field deployment would be required for analysis. In this work, the overall flow of the data-driven DTx analytics is reviewed to help researchers and practitioners to explore DTx datasets, to investigate contextual patterns associated with DTx usage, and to establish the (causal) relationship of DTx engagement and behavioral adherence. This review of the key components of data-driven analytics provides novel research directions in the analysis of mobile sensor and interaction datasets, which helps to iteratively improve the receptivity of existing DTx.Comment: This paper has been accepted by the IEEE/CAA Journal of Automatica Sinic

A smartphone-based health care chatbot to promote self-management of chronic pain (SELMA) : pilot randomized controlled trial

Background: Ongoing pain is one of the most common diseases and has major physical, psychological, social, and economic impacts. A mobile health intervention utilizing a fully automated text-based health care chatbot (TBHC) may offer an innovative way not only to deliver coping strategies and psychoeducation for pain management but also to build a working alliance between a participant and the TBHC. Objective: The objectives of this study are twofold: (1) to describe the design and implementation to promote the chatbot painSELfMAnagement (SELMA), a 2-month smartphone-based cognitive behavior therapy (CBT) TBHC intervention for pain self-management in patients with ongoing or cyclic pain, and (2) to present findings from a pilot randomized controlled trial, in which effectiveness, influence of intention to change behavior, pain duration, working alliance, acceptance, and adherence were evaluated. Methods: Participants were recruited online and in collaboration with pain experts, and were randomized to interact with SELMA for 8 weeks either every day or every other day concerning CBT-based pain management (n=59), or weekly concerning content not related to pain management (n=43). Pain-related impairment (primary outcome), general well-being, pain intensity, and the bond scale of working alliance were measured at baseline and postintervention. Intention to change behavior and pain duration were measured at baseline only, and acceptance postintervention was assessed via self-reporting instruments. Adherence was assessed via usage data. Results: From May 2018 to August 2018, 311 adults downloaded the SELMA app, 102 of whom consented to participate and met the inclusion criteria. The average age of the women (88/102, 86.4%) and men (14/102, 13.6%) participating was 43.7 (SD 12.7) years. Baseline group comparison did not differ with respect to any demographic or clinical variable. The intervention group reported no significant change in pain-related impairment (P=.68) compared to the control group postintervention. The intention to change behavior was positively related to pain-related impairment (P=.01) and pain intensity (P=.01). Working alliance with the TBHC SELMA was comparable to that obtained in guided internet therapies with human coaches. Participants enjoyed using the app, perceiving it as useful and easy to use. Participants of the intervention group replied with an average answer ratio of 0.71 (SD 0.20) to 200 (SD 58.45) conversations initiated by SELMA. Participants’ comments revealed an appreciation of the empathic and responsible interaction with the TBHC SELMA. A main criticism was that there was no option to enter free text for the patients’ own comments. Conclusions: SELMA is feasible, as revealed mainly by positive feedback and valuable suggestions for future revisions. For example, the participants’ intention to change behavior or a more homogenous sample (eg, with a specific type of chronic pain) should be considered in further tailoring of SELMA

COVID-19 what have we learned? The rise of social machines and connected devices in pandemic management following the concepts of predictive, preventive and personalised medicine

A comprehensive bibliographic review with R statistical methods of the COVID pandemic in PubMed literature and Web of Science Core Collection, supported with Google Scholar search. In addition, a case study review of emerging new approaches in different regions, using medical literature, academic literature, news articles and other reliable data sources. Public responses of mistrust about privacy data misuse differ across countries, depending on the chosen public communication strategy

Mobile Cloud Computing Model and Big Data Analysis for Healthcare Applications

Mobile devices are increasingly becoming an indispensable part of people\u27s daily life, facilitating to perform a variety of useful tasks. Mobile cloud computing integrates mobile and cloud computing to expand their capabilities and benefits and overcomes their limitations, such as limited memory, CPU power, and battery life. Big data analytics technologies enable extracting value from data having four Vs: volume, variety, velocity, and veracity. This paper discusses networked healthcare and the role of mobile cloud computing and big data analytics in its enablement. The motivation and development of networked healthcare applications and systems is presented along with the adoption of cloud computing in healthcare. A cloudlet-based mobile cloud-computing infrastructure to be used for healthcare big data applications is described. The techniques, tools, and applications of big data analytics are reviewed. Conclusions are drawn concerning the design of networked healthcare systems using big data and mobile cloud-computing technologies. An outlook on networked healthcare is given