Higher-Dimensional Timed Automata

We introduce a new formalism of higher-dimensional timed automata, based on van Glabbeek's higher-dimensional automata and Alur's timed automata. We prove that their reachability is PSPACE-complete and can be decided using zone-based algorithms. We also show how to use tensor products to combat state-space explosion and how to extend the setting to higher-dimensional hybrid automata

Petri nets for systems and synthetic biology

We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which uni¯es the qualita- tive, stochastic and continuous paradigms. Each perspective adds its con- tribution to the understanding of the system, thus the three approaches do not compete, but complement each other. We illustrate our approach by applying it to an extended model of the three stage cascade, which forms the core of the ERK signal transduction pathway. Consequently our focus is on transient behaviour analysis. We demonstrate how quali- tative descriptions are abstractions over stochastic or continuous descrip- tions, and show that the stochastic and continuous models approximate each other. Although our framework is based on Petri nets, it can be applied more widely to other formalisms which are used to model and analyse biochemical networks

Analysing oscillatory trends of discrete-state stochastic processes through HASL statistical model checking

The application of formal methods to the analysis of stochastic oscillators has been at the focus of several research works in recent times. In this paper we provide insights on the application of an expressive temporal logic formalism, namely the Hybrid Automata Stochastic Logic (HASL), to that issue. We show how one can take advantage of the expressive power of the HASL logic to define and assess relevant characteristics of (stochastic) oscillators