`The frozen accident' as an evolutionary adaptation: A rate distortion theory perspective on the dynamics and symmetries of genetic coding mechanisms

We survey some interpretations and related issues concerning the frozen hypothesis due to F. Crick and how it can be explained in terms of several natural mechanisms involving error correction codes, spin glasses, symmetry breaking and the characteristic robustness of genetic networks. The approach to most of these questions involves using elements of Shannon's rate distortion theory incorporating a semantic system which is meaningful for the relevant alphabets and vocabulary implemented in transmission of the genetic code. We apply the fundamental homology between information source uncertainty with the free energy density of a thermodynamical system with respect to transcriptional regulators and the communication channels of sequence/structure in proteins. This leads to the suggestion that the frozen accident may have been a type of evolutionary adaptation

A Combinatorial Methodology for Optimizing Non-Binary Graph-Based Codes: Theoretical Analysis and Applications in Data Storage

Non-binary (NB) low-density parity-check (LDPC) codes are graph-based codes that are increasingly being considered as a powerful error correction tool for modern dense storage devices. Optimizing NB-LDPC codes to overcome their error floor is one of the main code design challenges facing storage engineers upon deploying such codes in practice. Furthermore, the increasing levels of asymmetry incorporated by the channels underlying modern dense storage systems, e.g., multi-level Flash systems, exacerbates the error floor problem by widening the spectrum of problematic objects that contributes to the error floor of an NB-LDPC code. In a recent research, the weight consistency matrix (WCM) framework was introduced as an effective combinatorial NB-LDPC code optimization methodology that is suitable for modern Flash memory and magnetic recording (MR) systems. The WCM framework was used to optimize codes for asymmetric Flash channels, MR channels that have intrinsic memory, in addition to canonical symmetric additive white Gaussian noise channels. In this paper, we provide an in-depth theoretical analysis needed to understand and properly apply the WCM framework. We focus on general absorbing sets of type two (GASTs) as the detrimental objects of interest. In particular, we introduce a novel tree representation of a GAST called the unlabeled GAST tree, using which we prove that the WCM framework is optimal in the sense that it operates on the minimum number of matrices, which are the WCMs, to remove a GAST. Then, we enumerate WCMs and demonstrate the significance of the savings achieved by the WCM framework in the number of matrices processed to remove a GAST. Moreover, we provide a linear-algebraic analysis of the null spaces of WCMs associated with a GAST. We derive the minimum number of edge weight changes needed to remove a GAST via its WCMs, along with how to choose these changes. Additionally, we propose a new set of problematic objects, namely oscillating sets of type two (OSTs), which contribute to the error floor of NB-LDPC codes with even column weights on asymmetric channels, and we show how to customize the WCM framework to remove OSTs. We also extend the domain of the WCM framework applications by demonstrating its benefits in optimizing column weight 5 codes, codes used over Flash channels with soft information, and spatially-coupled codes. The performance gains achieved via the WCM framework range between 1 and nearly 2.5 orders of magnitude in the error floor region over interesting channels

Image segmentation with adaptive region growing based on a polynomial surface model

A new method for segmenting intensity images into smooth surface segments is presented. The main idea is to divide the image into flat, planar, convex, concave, and saddle patches that coincide as well as possible with meaningful object features in the image. Therefore, we propose an adaptive region growing algorithm based on low-degree polynomial fitting. The algorithm uses a new adaptive thresholding technique with the L∞ fitting cost as a segmentation criterion. The polynomial degree and the fitting error are automatically adapted during the region growing process. The main contribution is that the algorithm detects outliers and edges, distinguishes between strong and smooth intensity transitions and finds surface segments that are bent in a certain way. As a result, the surface segments corresponding to meaningful object features and the contours separating the surface segments coincide with real-image object edges. Moreover, the curvature-based surface shape information facilitates many tasks in image analysis, such as object recognition performed on the polynomial representation. The polynomial representation provides good image approximation while preserving all the necessary details of the objects in the reconstructed images. The method outperforms existing techniques when segmenting images of objects with diffuse reflecting surfaces

Representation Learning: A Review and New Perspectives

The success of machine learning algorithms generally depends on data representation, and we hypothesize that this is because different representations can entangle and hide more or less the different explanatory factors of variation behind the data. Although specific domain knowledge can be used to help design representations, learning with generic priors can also be used, and the quest for AI is motivating the design of more powerful representation-learning algorithms implementing such priors. This paper reviews recent work in the area of unsupervised feature learning and deep learning, covering advances in probabilistic models, auto-encoders, manifold learning, and deep networks. This motivates longer-term unanswered questions about the appropriate objectives for learning good representations, for computing representations (i.e., inference), and the geometrical connections between representation learning, density estimation and manifold learning

Seven properties of self-organization in the human brain

The principle of self-organization has acquired a fundamental significance in the newly emerging field of computational philosophy. Self-organizing systems have been described in various domains in science and philosophy including physics, neuroscience, biology and medicine, ecology, and sociology. While system architecture and their general purpose may depend on domain-specific concepts and definitions, there are (at least) seven key properties of self-organization clearly identified in brain systems: 1) modular connectivity, 2) unsupervised learning, 3) adaptive ability, 4) functional resiliency, 5) functional plasticity, 6) from-local-to-global functional organization, and 7) dynamic system growth. These are defined here in the light of insight from neurobiology, cognitive neuroscience and Adaptive Resonance Theory (ART), and physics to show that self-organization achieves stability and functional plasticity while minimizing structural system complexity. A specific example informed by empirical research is discussed to illustrate how modularity, adaptive learning, and dynamic network growth enable stable yet plastic somatosensory representation for human grip force control. Implications for the design of “strong” artificial intelligence in robotics are brought forward