29,281 research outputs found
Dynamical strategies for obstacle avoidance during Dictyostelium discoideum aggregation: a Multi-agent system model
Chemotaxis, the movement of an organism in response to chemical stimuli, is a
typical feature of many microbiological systems. In particular, the social
amoeba \textit{Disctyostelium discoideum} is widely used as a model organism,
but it is not still clear how it behaves in heterogeneous environments. A few
models focusing on mechanical features have already addressed the question;
however, we suggest that phenomenological models focusing on the population
dynamics may provide new meaningful data. Consequently, by means of a specific
Multi-agent system model, we study the dynamical features emerging from complex
social interactions among individuals belonging to amoeba colonies.\\ After
defining an appropriate metric to quantitatively estimate the gathering
process, we find that: a) obstacles play the role of local topological
perturbation, as they alter the flux of chemical signals; b) physical obstacles
(blocking the cellular motion and the chemical flux) and purely chemical
obstacles (only interfering with chemical flux) elicit similar dynamical
behaviors; c) a minimal program for robustly gathering simulated cells does not
involve mechanisms for obstacle sensing and avoidance; d) fluctuations of the
dynamics concur in preventing multiple stable clusters. Comparing those
findings with previous results, we speculate about the fact that chemotactic
cells can avoid obstacles by simply following the altered chemical gradient.
Social interactions are sufficient to guarantee the aggregation of the whole
colony past numerous obstacles
Regional Heterogeneity and Chinaâs International Trade: Sufficient Lumpiness or Not?
This paper explores whether there is sufficient lumpiness or heterogeneity in the relative endowments (capital, labour and skills) of the regions of China to affect Chinaâs specialization and trade patterns. It does so using both the lens condition to identify the violation of factor price equalization across regions, and direct evidence on regional trade and specialization. The results are sensitive to the level of regional aggregation. The paper concludes, however, that China was sufficiently lumpy as recently as 2004 to affect it pattern of international trade.Trade, lumpiness, regions, China
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Interactive Visual Analysis of Heterogeneous Cohort Study Data
Cohort studies in medicine are conducted to enable the study of medical hypotheses in large samples. Often, a large amount of heterogeneous data is acquired from many subjects. The analysis is usually hypothesis-driven, i.e., a specific subset of such data is studied to confirm or reject specific hypotheses. In this paper, we demonstrate how we enable the interactive visual exploration and analysis of such data, helping with the generation of new hypotheses and contributing to the process of validating them. We propose a data-cube based model which handles partially overlapping data subsets during the interactive visualization. This model enables seamless integration of the heterogeneous data, as well as linking spatial and non-spatial views on these data. We implemented this model in an application prototype, and used it to analyze data acquired in the context of a cohort study on cognitive aging. We present case-study analyses of selected aspects of brain connectivity by using the prototype implementation of the presented model, to demonstrate its potential and flexibility
In Silico Approaches and the Role of Ontologies in Aging Research
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney and skin
Extracting, Transforming and Archiving Scientific Data
It is becoming common to archive research datasets that are not only large
but also numerous. In addition, their corresponding metadata and the software
required to analyse or display them need to be archived. Yet the manual
curation of research data can be difficult and expensive, particularly in very
large digital repositories, hence the importance of models and tools for
automating digital curation tasks. The automation of these tasks faces three
major challenges: (1) research data and data sources are highly heterogeneous,
(2) future research needs are difficult to anticipate, (3) data is hard to
index. To address these problems, we propose the Extract, Transform and Archive
(ETA) model for managing and mechanizing the curation of research data.
Specifically, we propose a scalable strategy for addressing the research-data
problem, ranging from the extraction of legacy data to its long-term storage.
We review some existing solutions and propose novel avenues of research.Comment: 8 pages, Fourth Workshop on Very Large Digital Libraries, 201
Beyond Volume: The Impact of Complex Healthcare Data on the Machine Learning Pipeline
From medical charts to national census, healthcare has traditionally operated
under a paper-based paradigm. However, the past decade has marked a long and
arduous transformation bringing healthcare into the digital age. Ranging from
electronic health records, to digitized imaging and laboratory reports, to
public health datasets, today, healthcare now generates an incredible amount of
digital information. Such a wealth of data presents an exciting opportunity for
integrated machine learning solutions to address problems across multiple
facets of healthcare practice and administration. Unfortunately, the ability to
derive accurate and informative insights requires more than the ability to
execute machine learning models. Rather, a deeper understanding of the data on
which the models are run is imperative for their success. While a significant
effort has been undertaken to develop models able to process the volume of data
obtained during the analysis of millions of digitalized patient records, it is
important to remember that volume represents only one aspect of the data. In
fact, drawing on data from an increasingly diverse set of sources, healthcare
data presents an incredibly complex set of attributes that must be accounted
for throughout the machine learning pipeline. This chapter focuses on
highlighting such challenges, and is broken down into three distinct
components, each representing a phase of the pipeline. We begin with attributes
of the data accounted for during preprocessing, then move to considerations
during model building, and end with challenges to the interpretation of model
output. For each component, we present a discussion around data as it relates
to the healthcare domain and offer insight into the challenges each may impose
on the efficiency of machine learning techniques.Comment: Healthcare Informatics, Machine Learning, Knowledge Discovery: 20
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