A P2P Integration Architecture for Protein Resources

The availability of a direct pathway from a primary sequence (denovo or DNA derived) to macromolecular structure to biological function using computer-based tools is the ultimate goal for a protein scientist. Today\u27s state of the art protein resources and on-going research and experiments provide the raw data that can enable protein scientists to achieve at least some steps of this goal. Thus, protein scientists are looking towards taking their benchtop research from the specific to a much broader base of using the large resources of available electronic information. However, currently the burden falls on the scientist to manually interface with each data resource, integrate the required information, and then finally interpret the results. Their discoveries are impeded by the lack of tools that can not only bring integrated information from several known data resources, but also weave in information as it is discovered and brought online by other research groups. We propose a novel peer-to-peer based architecture that allows protein scientists to share resources in the form of data and tools within their community, facilitating ad hoc, decentralized sharing of data. In this paper, we present an overview of this integration architecture and briefly describe the tools that are essential to this framework

Modeling views in the layered view model for XML using UML

In data engineering, view formalisms are used to provide flexibility to users and user applications by allowing them to extract and elaborate data from the stored data sources. Conversely, since the introduction of Extensible Markup Language (XML), it is fast emerging as the dominant standard for storing, describing, and interchanging data among various web and heterogeneous data sources. In combination with XML Schema, XML provides rich facilities for defining and constraining user-defined data semantics and properties, a feature that is unique to XML. In this context, it is interesting to investigate traditional database features, such as view models and view design techniques for XML. However, traditional view formalisms are strongly coupled to the data language and its syntax, thus it proves to be a difficult task to support views in the case of semi-structured data models. Therefore, in this paper we propose a Layered View Model (LVM) for XML with conceptual and schemata extensions. Here our work is three-fold; first we propose an approach to separate the implementation and conceptual aspects of the views that provides a clear separation of concerns, thus, allowing analysis and design of views to be separated from their implementation. Secondly, we define representations to express and construct these views at the conceptual level. Thirdly, we define a view transformation methodology for XML views in the LVM, which carries out automated transformation to a view schema and a view query expression in an appropriate query language. Also, to validate and apply the LVM concepts, methods and transformations developed, we propose a view-driven application development framework with the flexibility to develop web and database applications for XML, at varying levels of abstraction

Beyond definition: Organising semantic information in bilingual dictionaries

This paper considers the process of organising semantic information in bilingual dictionaries with diachronic coverage, from selecting the textual source-material to designing the entries. The discussion centres on practical aspects of ancient Greek lexicography. First, the traditional semantic frameworks are described. Then, more recent approaches are noted, notably those of Adrados and of Chadwick, both of which aim to integrate contextual data within a semantic framework. Since the relevance of contextual information varies with lemma part of speech, different configurations are required for entries describing nouns, adjectives, and verbs. These are illustrated by three entries from a Greek-English dictionary currently being written at Cambridge. In order to organise data to this level of specificity, stylistic templates are indispensable, and digital software provides a means of providing them. However, systems designed for writing new dictionaries require different features from those designed for encoding pre-existing texts. A description is given of how the lexicographic requirements of the Cambridge dictionary were met by a user-designed system

Technological undercurrents and global information circulation

pp. 217-23

Data Ontology and an Information System Realization for Web-Based Management of Image Measurements

Image acquisition, processing, and quantification of objects (morphometry) require the integration of data inputs and outputs originating from heterogeneous sources. Management of the data exchange along this workflow in a systematic manner poses several challenges, notably the description of the heterogeneous meta-data and the interoperability between the software used. The use of integrated software solutions for morphometry and management of imaging data in combination with ontologies can reduce meta-data loss and greatly facilitate subsequent data analysis. This paper presents an integrated information system, called LabIS. The system has the objectives to automate (i) the process of storage, annotation, and querying of image measurements and (ii) to provide means for data sharing with third party applications consuming measurement data using open standard communication protocols. LabIS implements 3-tier architecture with a relational database back-end and an application logic middle tier realizing web-based user interface for reporting and annotation and a web-service communication layer. The image processing and morphometry functionality is backed by interoperability with ImageJ, a public domain image processing software, via integrated clients. Instrumental for the latter feat was the construction of a data ontology representing the common measurement data model. LabIS supports user profiling and can store arbitrary types of measurements, regions of interest, calibrations, and ImageJ settings. Interpretation of the stored measurements is facilitated by atlas mapping and ontology-based markup. The system can be used as an experimental workflow management tool allowing for description and reporting of the performed experiments. LabIS can be also used as a measurements repository that can be transparently accessed by computational environments, such as Matlab. Finally, the system can be used as a data sharing tool

Semantics and Validation of Shapes Schemas for RDF

We present a formal semantics and proof of soundness for shapes schemas, an expressive schema language for RDF graphs that is the foundation of Shape Expressions Language 2.0. It can be used to describe the vocabulary and the structure of an RDF graph, and to constrain the admissible properties and values for nodes in that graph. The language defines a typing mechanism called shapes against which nodes of the graph can be checked. It includes an algebraic grouping operator, a choice operator and cardinality constraints for the number of allowed occurrences of a property. Shapes can be combined using Boolean operators, and can use possibly recursive references to other shapes. We describe the syntax of the language and define its semantics. The semantics is proven to be well-defined for schemas that satisfy a reasonable syntactic restriction, namely stratified use of negation and recursion. We present two algorithms for the validation of an RDF graph against a shapes schema. The first algorithm is a direct implementation of the semantics, whereas the second is a non-trivial improvement. We also briefly give implementation guidelines

The Molecular Pages of the mesotelencephalic dopamine consortium (DopaNet)

BACKGROUND: DopaNet is a Systems Biology initiative that aims to investigate precisely and quantitatively all the aspects of neurotransmission in a specific neuronal system, the mesotelencephalic dopamine system. The project should lead to large-scale models of molecular and cellular processes involved in neuronal signaling. A prerequisite is the proper storage of knowledge coming from the literature. METHODS: DopaNet Molecular Pages are highly structured descriptions of quantitative parameters related to a specific molecular complex involved in neuronal signal processing. A Molecular Page is built by maintainers who are experts in the field, and responsible for the quality of the page content. Each piece of data is identified by a specific ontology code, annotated (method of acquisition, species, etc.) and linked to the relevant bibliography. The Molecular Pages are stored as XML files, and processed through the DopaNet Web Service, which provides functionalities to edit the Molecular Pages, to cross-link the Pages and generate the public display, and to search them. CONCLUSIONS: DopaNet Molecular Pages are one of the core resources of the DopaNet project but should be of widespread utility in the field of Systems Neurobiology

Trends in modeling Biomedical Complex Systems.

In this paper we provide an introduction to the techniques for multi-scale complex biological systems, from the single bio-molecule to the cell, combining theoretical modeling, experiments, informatics tools and technologies suitable for biological and biomedical research, which are becoming increasingly multidisciplinary, multidimensional and information-driven. The most important concepts on mathematical modeling methodologies and statistical inference, bioinformatics and standards tools to investigate complex biomedical systems are discussed and the prominent literature useful to both the practitioner and the theoretician are presented.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

XML: aplicações e tecnologias associadas: 6th National Conference

This volume contains the papers presented at the Sixth Portuguese XML Conference, called XATA (XML, Aplicações e Tecnologias Associadas), held in Évora, Portugal, 14-15 February, 2008. The conference followed on from a successful series held throughout Portugal in the last years: XATA2003 was held in Braga, XATA2004 was held in Porto, XATA2005 was held in Braga, XATA2006 was held in Portalegre and XATA2007 was held in Lisboa. Dued to research evaluation criteria that are being used to evaluate researchers and research centers national conferences are becoming deserted. Many did not manage to gather enough submissions to proceed in this scenario. XATA made it through. However with a large decrease in the number of submissions. In this edition a special meeting will join the steering committee with some interested attendees to discuss XATA's future: internationalization, conference model, ... We think XATA is important in the national context. It has succeeded in gathering and identifying a comunity that shares the same research interests and has promoted some colaborations. We want to keep "the wheel spinning"... This edition has its program distributed by first day's afternoon and next day's morning. This way we are facilitating travel arrangements and we will have one night to meet