An interpretable deep learning classifier for epileptic seizure prediction using EEG data

Deep learning has served pattern classification in many applications, with a performance which often well exceeds that of other machine learning paradigms. Yet, in general, deep learning has used computational architectures built, albeit partially, by ad hoc means, and its classification decisions are not necessarily interpretable in terms of knowledge relevant to the application it serves. This is often referred to as the black box problem, which in certain applications, such as epileptic seizure prediction, can be a serious impediment. The purpose of this study is to investigate an interpretable deep learning classifier for epileptic EEG-driven seizure prediction. This neural network is interpretable because its layers can be visualized and interpreted as a result of a novel architecture where the learned weights follow from signal processing computations such as frequency sub-band and spatial filters. Consequently, the extracted features are no longer abstract as they correspond to the features commonly used for decoding EEG data. In addition, the network uses layer-wise relevance propagation to reveal pertinent features which can further explain the computations leading to the decisions. In seizure prediction experiments using the CHB-MIT data set, the method produced classification results which improved on the state-of-the art, with first network layer filters corresponding to clinically relevant frequency bands, and the input channels in the brain location in which the seizure originates contributing most significantly to the network predictions

EEG-based Brain-Computer Interfaces (BCIs): A Survey of Recent Studies on Signal Sensing Technologies and Computational Intelligence Approaches and Their Applications.

Brain-Computer interfaces (BCIs) enhance the capability of human brain activities to interact with the environment. Recent advancements in technology and machine learning algorithms have increased interest in electroencephalographic (EEG)-based BCI applications. EEG-based intelligent BCI systems can facilitate continuous monitoring of fluctuations in human cognitive states under monotonous tasks, which is both beneficial for people in need of healthcare support and general researchers in different domain areas. In this review, we survey the recent literature on EEG signal sensing technologies and computational intelligence approaches in BCI applications, compensating for the gaps in the systematic summary of the past five years. Specifically, we first review the current status of BCI and signal sensing technologies for collecting reliable EEG signals. Then, we demonstrate state-of-the-art computational intelligence techniques, including fuzzy models and transfer learning in machine learning and deep learning algorithms, to detect, monitor, and maintain human cognitive states and task performance in prevalent applications. Finally, we present a couple of innovative BCI-inspired healthcare applications and discuss future research directions in EEG-based BCI research

Pattern Recognition

Pattern recognition is a very wide research field. It involves factors as diverse as sensors, feature extraction, pattern classification, decision fusion, applications and others. The signals processed are commonly one, two or three dimensional, the processing is done in real- time or takes hours and days, some systems look for one narrow object class, others search huge databases for entries with at least a small amount of similarity. No single person can claim expertise across the whole field, which develops rapidly, updates its paradigms and comprehends several philosophical approaches. This book reflects this diversity by presenting a selection of recent developments within the area of pattern recognition and related fields. It covers theoretical advances in classification and feature extraction as well as application-oriented works. Authors of these 25 works present and advocate recent achievements of their research related to the field of pattern recognition

Epilepsy

With the vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, InTech proudly presents the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well

EEG Phase Synchronization in Persons With Depression Subjected to Transcranial Magnetic Stimulation

Aim: The main objective of this work was to study the impact of repetitive Transcranial Magnetic Stimulation (rTMS) treatment on brain activity in 8 patients with major depressive disorder (MDD) and 10 patients with bipolar disorder (BP). Changes due to rTMS stimulation of the left dorsolateral prefrontal cortex (DLPFC) were investigated considering separately responders and non-responders to therapy in each of both groups. The aim of the research is to determine whether non-responders differ from responders suffered from both diseases, as well as if any change occurred due to rTMS across consecutive rTMS sessions.Methods: The graph-theory-based connectivity analysis of non-linearity measure of phase interdependencies—Phase Locking Value (PLV)—was examined from EEG data. The approximately 15-min EEG recordings from each of participants were recorded before and after 1st, 10th, and 20th session, respectively. PLV calculated from data was analyzed using principal graph theory indices (strength and degree) within five physiological frequency bands and in individual channels separately. The impact of rTMS on the EEG connectivity in every group of patients evaluated by PLV was assessed.Results: Each of four groups reacted differently to rTMS treatment. The strength and degree of PLV increased in gamma band in both groups of responders. Moreover, an increase of indices in beta band for BP-responders was observed. While, in MDD-non-responders the indices decreased in gamma band and increased in beta band. Moreover, the index strength was lower in alpha band for BP- non-responders. The rTMS stimulation caused topographically specific changes, i.e., the increase of the activity in the left DLPFC as well as in other brain regions such as right parieto-occipital areas.Conclusions: The analysis of PLV allowed for evaluation of the rTMS impact on the EEG activity in each group of patients. The changes of PLV under stimulation might be a good indicator of response to depression treatment permitting to improve the effectiveness of therapy

Reading the brain’s personality: using machine learning to investigate the relationships between EEG and depressivity

Electroencephalography (EEG) measures electrical signals on the scalp and can give information about processes near the surface of the brain (cortex). The goal of our research was to create models that predict depressivity (mapping to personality in general, not just sickness) and to find potential biomarkers in EEG data. First, to provide our models with cleaner EEG data, we designed a novel single-channel physiology-based eye blink artefact removal method and a mains power noise removal method. Then, we assessed two main machine learning model types (classification- and regression-based) with a total of eighteen sub-types to predict the depressivity of participants. The models were generated by combining four signal processing techniques with a) three classification techniques, and b) three regression techniques. The experimental results showed that both types of models perform well in depressivity prediction and one regression-based model (Reg-FFT-LSBoost) showed a significant depressivity prediction performance, especially for female group. More importantly, we found that a specific EEG frequency band (the gamma band) made major contributions to depressivity prediction. Apart from that, the alpha and beta band may make modest contributions. Specific locations (T7, T8, and C3) made major contributions to depressivity prediction. Frontal locations may also have some influence. We also found that the combination of both eye states’ EEG data showed a better depressivity prediction ability. Compared to the eyes closed data, the EEG data obtained from the state of eyes open were more suitable for assessing depressivity. In brief, the outcomes of this research provided the possibilities for translating the EEG data for depressivity measure. Furthermore, there are possibilities to extend the research to apply to other mental disorders’ prediction, such as anxiety