4,077 research outputs found
Resolution enhancement, noise suppression, and joint T2* decay estimation in dual-echo sodium-23 MR imaging using anatomically-guided reconstruction
Purpose: Sodium MRI is challenging because of the low tissue concentration of
the 23 Na nucleus and its extremely fast biexponential transverse relaxation
rate. In this article, we present an iterative reconstruction framework using
dual-echo 23Na data and exploiting anatomical prior information (AGR) from
high-resolution, low-noise, 1 H MR images. This framework enables the
estimation and modeling of the spatially-varying signal decay due to transverse
relaxation during readout (AGRdm), which leads to images of better resolution
and reduced noise resulting in improved quantification of the reconstructed
23Na images.
Methods: The proposed framework was evaluated using reconstructions of 30
noise realizations of realistic simulations of dual echo twisted projection
imaging (TPI) 23 Na data. Moreover, three dual echo 23 Na TPI brain data sets
of healthy controls acquired on a 3T Siemens Prisma system were reconstructed
using conventional reconstruction, AGR and AGRdm.
Results: Our simulations show that compared to conventional reconstructions,
AGR and AGRdm show improved bias-noise characteristics in several regions of
the brain. Moreover, AGR and AGRdm images show more anatomical detail and less
noise in the reconstructions of the experimental data sets. Compared to AGR and
the conventional reconstruction, AGRdm shows higher contrast in the sodium
concentration ratio between gray and white matter and between gray matter and
the brain stem.
Conclusion: AGR and AGRdm generate 23 Na images with high resolution, high
levels of anatomical detail, and low levels of noise, potentially enabling
high-quality 23 Na MR imaging at 3T.Comment: 19 pages, 8 figures, 2 table
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The role of HG in the analysis of temporal iteration and interaural correlation
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Sequence Development and Expansion of Zero J-Modulation Echo-Planar Chemical Shift Imaging in Three Dimensions (3D ZJ-EPSI)
580,350 (35%) of 1,660,290 cancer patients are estimated to die in the US in 2013. Routine monitoring by X-Rays and CT scans are hazardous and evaluating this disease is time consuming. Magnetic Resonance Spectroscopy (MRS) has changed this mal-routine significantly in the past few years. MRS can help with better understanding of tumor pathology, study of tumor vascularization and progress, and having a predicting value for the treatment response and disease-free survival of the patients even before they start their treatment.
Unfortunately, MRS is still not a common practice among the medical community because of three main reasons: First and far most is the fact that MRS acquisition is usually very time consuming. For a classic 1H 3D MRS with a spatial matrix of 20x18x10 with TR = 1000 ms, the scan time is about 1 hour which is "practically" impossible to acquire on a patient. Second, MR time is extremely expensive. Depending on the site, specific procedure, and strength of the magnet a simple MR study can cost somewhere between 1000 to 3500 US dollars. Finally, non-standardized MRS acquisitions and analysis protocols could create havoc in interpretation and usefulness of the technique. MRS scan parameters such as spatial resolution and echo times have been used non-uniformly in variety of different combinations in research and clinical studies. These parameters must be chosen with utmost care as they have direct impact on signal to noise ratio, quantification of the metabolites, and an overall interpretation of the results.
For the reasons said, having a method that could shorten the length of an MRS scan, reduce the cost, and potentially become a sensible routine in clinical practice is of a huge value. 3D Zero J-modulation Echo Planar Chemical Shift Imaging (3D ZJ-EPSI) is a fast MRS technique that can not only achieve all that was mentioned above, it can also provide additional detailed anatomical/pathological information due to its 3D nature. 3D ZJ-EPSI technique acquires proton magnetic resonance spectroscopy with time to acquisition (TE') of less than 1.7 ms and zero J-modulation effects. 3D ZJ-EPSI consisted of a slab excitation, followed by two phase encoding gradients and an echo planar switching readout gradient. The Free induction decay (FID) acquisition occurred during the plateaus of the switching gradient.
The lipid suppression was achieved via ten Regional Saturation Technique (REST) pulses placed prior to the main slab excitation RF. The water suppression technique was a chemical shift selective (CHESS) pulse with RF-80º-80º-160º that was placed prior to lipid suppression pulses. The sequence was tested on a brain metabolite phantom with spatial resolution of 15×15×6 mm3 in 4:04 min, yielding spectra with comparable quality to the spectra obtained using conventional chemical shift imaging (CSI) technique taking 56:34 min. The sequence was also tested on human subjects with spatial resolution of 15×15×6 mm3 and 7.5×7.5×6 mm3 and the metabolic ratios were calculated and compared to literature values. Signals of coupled resonances were improved due to near zero TE' and zero J-modulation effects, while the macromolecules were more pronounced in the spectra. With non-water suppressed sequence, variations of waterline shape of different tissues in three spatial dimensions could be studied. The 3D ZJ-EPSI technique addresses the need for a fast MRS method that allows for a better quantification capability by acquiring proton spectra with zero J-modulation. The short acquisition time and near zero TE' make this methodology suitable for uniform quantification of metabolites in clinical studies
Reward circuitry is perturbed in the absence of the serotonin transporter
The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems. These three systems are intimately involved in normal physiological functioning of the brain and implicated in numerous pathological conditions. Here we use high-resolution magnetic resonance imaging (MRI) and spectroscopy to elucidate the effects of disruption of the serotonin transporter in an animal model system: the SERT knock-out mouse. Employing manganese-enhanced MRI, we injected Mn^(2+) into the prefrontal cortex and obtained 3D MR images at specific time points in cohorts of SERT and normal mice. Statistical analysis of co-registered datasets demonstrated that active circuitry originating in the prefrontal cortex in the SERT knock-out is dramatically altered, with a bias towards more posterior areas (substantia nigra, ventral tegmental area, and Raphé nuclei) directly involved in the reward circuit. Injection site and tracing were confirmed with traditional track tracers by optical microscopy. In contrast, metabolite levels were essentially normal in the SERT knock-out by in vivo magnetic resonance spectroscopy and little or no anatomical differences between SERT knock-out and normal mice were detected by MRI. These findings point to modulation of the limbic cortical–ventral striatopallidal by disruption of SERT function. Thus, molecular disruptions of SERT that produce behavioral changes also alter the functional anatomy of the reward circuitry in which all the monoamine systems are involved
Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain
The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here
K-Bayes Reconstruction for Perfusion MRI I: Concepts and Application
Despite the continued spread of magnetic resonance imaging (MRI) methods in scientific studies and clinical diagnosis, MRI applications are mostly restricted to high-resolution modalities, such as structural MRI. While perfusion MRI gives complementary information on blood flow in the brain, its reduced resolution limits its power for detecting specific disease effects on perfusion patterns. This reduced resolution is compounded by artifacts such as partial volume effects, Gibbs ringing, and aliasing, which are caused by necessarily limited k-space sampling and the subsequent use of discrete Fourier transform (DFT) reconstruction. In this study, a Bayesian modeling procedure (K-Bayes) is developed for the reconstruction of perfusion MRI. The K-Bayes approach (described in detail in Part II: Modeling and Technical Development) combines a process model for the MRI signal in k-space with a Markov random field prior distribution that incorporates high-resolution segmented structural MRI information. A simulation study was performed to determine qualitative and quantitative improvements in K-Bayes reconstructed images compared with those obtained via DFT. The improvements were validated using in vivo perfusion MRI data of the human brain. The K-Bayes reconstructed images were demonstrated to provide reduced bias, increased precision, greater effect sizes, and higher resolution than those obtained using DFT
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