34 research outputs found
Corticospinal Tract (CST) reconstruction based on fiber orientation distributions(FODs) tractography
The Corticospinal Tract (CST) is a part of pyramidal tract (PT), and it can
innervate the voluntary movement of skeletal muscle through spinal interneurons
(the 4th layer of the Rexed gray board layers), and anterior horn motorneurons
(which control trunk and proximal limb muscles). Spinal cord injury (SCI) is a
highly disabling disease often caused by traffic accidents. The recovery of CST
and the functional reconstruction of spinal anterior horn motor neurons play an
essential role in the treatment of SCI. However, the localization and
reconstruction of CST are still challenging issues; the accuracy of the
geometric reconstruction can directly affect the results of the surgery. The
main contribution of this paper is the reconstruction of the CST based on the
fiber orientation distributions (FODs) tractography. Differing from
tensor-based tractography in which the primary direction is a determined
orientation, the direction of FODs tractography is determined by the
probability. The spherical harmonics (SPHARM) can be used to approximate the
efficiency of FODs tractography. We manually delineate the three ROIs (the
posterior limb of the internal capsule, the cerebral peduncle, and the anterior
pontine area) by the ITK-SNAP software, and use the pipeline software to
reconstruct both the left and right sides of the CST fibers. Our results
demonstrate that FOD-based tractography can show more and correct anatomical
CST fiber bundles
Fronto-medial electrode placement for electroconvulsive treatment of depression
Electroconvulsive therapy (ECT) is the most effective treatment for severe treatment-resistant depression but concern about cognitive side-effects, particularly memory loss, limits its use. Recent observational studies on large groups of patients who have received ECT report that cognitive side-effects were associated with electric field (EF) induced increases in hippocampal volume, whereas therapeutic efficacy was associated with EF induced increases in sagittal brain structures. The aim in the present study was to determine whether a novel fronto-medial (FM) ECT electrode placement would minimize electric fields in bilateral hippocampi (HIP) whilst maximizing electric fields in dorsal sagittal cortical regions. An anatomically detailed computational head model was used with finite element analysis, to calculate ECT-induced electric fields in specific brain regions identified by translational neuroimaging studies of treatment-resistant depressive illness, for a range of electrode placements. As hypothesized, compared to traditional bitemporal (BT) electrode placement, a specific FM electrode placement reduced bilateral hippocampal electric fields two-to-three-fold, whilst the electric fields in the dorsal anterior cingulate (dAC) were increased by approximately the same amount. We highlight the clinical relevance of this specific FM electrode placement for ECT, which may significantly reduce cognitive and non-cognitive side-effects and suggest a clinical trial is indicated
Uncertainty Estimation using the Local Lipschitz for Deep Learning Image Reconstruction Models
The use of supervised deep neural network approaches has been investigated to
solve inverse problems in all domains, especially radiology where imaging
technologies are at the heart of diagnostics. However, in deployment, these
models are exposed to input distributions that are widely shifted from training
data, due in part to data biases or drifts. It becomes crucial to know whether
a given input lies outside the training data distribution before relying on the
reconstruction for diagnosis. The goal of this work is three-fold: (i)
demonstrate use of the local Lipshitz value as an uncertainty estimation
threshold for determining suitable performance, (ii) provide method for
identifying out-of-distribution (OOD) images where the model may not have
generalized, and (iii) use the local Lipschitz values to guide proper data
augmentation through identifying false positives and decrease epistemic
uncertainty. We provide results for both MRI reconstruction and CT sparse view
to full view reconstruction using AUTOMAP and UNET architectures due to it
being pertinent in the medical domain that reconstructed images remain
diagnostically accurate
"MASSIVE" Brain Dataset: Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation
PURPOSE: In this work, we present the MASSIVE (Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation) brain dataset of a single healthy subject, which is intended to facilitate diffusion MRI (dMRI) modeling and methodology development. METHODS: MRI data of one healthy subject (female, 25 years) were acquired on a clinical 3 Tesla system (Philips Achieva) with an eight-channel head coil. In total, the subject was scanned on 18 different occasions with a total acquisition time of 22.5 h. The dMRI data were acquired with an isotropic resolution of 2.5 mm(3) and distributed over five shells with b-values up to 4000 s/mm(2) and two Cartesian grids with b-values up to 9000 s/mm(2) . RESULTS: The final dataset consists of 8000 dMRI volumes, corresponding B0 field maps and noise maps for subsets of the dMRI scans, and ten three-dimensional FLAIR, T1 -, and T2 -weighted scans. The average signal-to-noise-ratio of the non-diffusion-weighted images was roughly 35. CONCLUSION: This unique set of in vivo MRI data will provide a robust framework to evaluate novel diffusion processing techniques and to reliably compare different approaches for diffusion modeling. The MASSIVE dataset is made publically available (both unprocessed and processed) on www.massive-data.org. Magn Reson Med, 2016
Structural connectivity-based segmentation of the human entorhinal cortex
The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posteromedial (pmEC) and anterolateral (alEC) parts, but uncertainty remains about the choice of imaging modality and seed regions, in particular in light of a substantial revision of the classical model of EC connectivity based on novel insights from rodent anatomy. Here, we used structural, not functional imaging, namely diffusion tensor imaging (DTI) and probabilistic tractography to segment the human EC based on differential connectivity to other brain regions known to project selectively to MEC or LEC. We defined MEC as more strongly connected with presubiculum and retrosplenial cortex (RSC), and LEC as more strongly connected with distal CA1 and proximal subiculum (dCA1pSub) and lateral orbitofrontal cortex (OFC). Although our DTI segmentation had a larger medial-lateral component than in the previous fMRI studies, our results show that the human MEC and LEC homologues have a border oriented both towards the posterior-anterior and medial-lateral axes, supporting the differentiation between pmEC and alEC