Symmetric Interconnection Networks from Cubic Crystal Lattices

Torus networks of moderate degree have been widely used in the supercomputer industry. Tori are superb when used for executing applications that require near-neighbor communications. Nevertheless, they are not so good when dealing with global communications. Hence, typical 3D implementations have evolved to 5D networks, among other reasons, to reduce network distances. Most of these big systems are mixed-radix tori which are not the best option for minimizing distances and efficiently using network resources. This paper is focused on improving the topological properties of these networks. By using integral matrices to deal with Cayley graphs over Abelian groups, we have been able to propose and analyze a family of high-dimensional grid-based interconnection networks. As they are built over $n$-dimensional grids that induce a regular tiling of the space, these topologies have been denoted \textsl{lattice graphs}. We will focus on cubic crystal lattices for modeling symmetric 3D networks. Other higher dimensional networks can be composed over these graphs, as illustrated in this research. Easy network partitioning can also take advantage of this network composition operation. Minimal routing algorithms are also provided for these new topologies. Finally, some practical issues such as implementability and preliminary performance evaluations have been addressed

Towards Operator-less Data Centers Through Data-Driven, Predictive, Proactive Autonomics

Continued reliance on human operators for managing data centers is a major impediment for them from ever reaching extreme dimensions. Large computer systems in general, and data centers in particular, will ultimately be managed using predictive computational and executable models obtained through data-science tools, and at that point, the intervention of humans will be limited to setting high-level goals and policies rather than performing low-level operations. Data-driven autonomics, where management and control are based on holistic predictive models that are built and updated using live data, opens one possible path towards limiting the role of operators in data centers. In this paper, we present a data-science study of a public Google dataset collected in a 12K-node cluster with the goal of building and evaluating predictive models for node failures. Our results support the practicality of a data-driven approach by showing the effectiveness of predictive models based on data found in typical data center logs. We use BigQuery, the big data SQL platform from the Google Cloud suite, to process massive amounts of data and generate a rich feature set characterizing node state over time. We describe how an ensemble classifier can be built out of many Random Forest classifiers each trained on these features, to predict if nodes will fail in a future 24-hour window. Our evaluation reveals that if we limit false positive rates to 5%, we can achieve true positive rates between 27% and 88% with precision varying between 50% and 72%.This level of performance allows us to recover large fraction of jobs' executions (by redirecting them to other nodes when a failure of the present node is predicted) that would otherwise have been wasted due to failures. [...

Investigating the pathogenesis of mitochondrial dysfunction in mitochondrial and other myopathies

PhD ThesisSkeletal muscle contains a large number of mitochondria, known for their production of ATP via oxidative phosphorylation, which is of vital importance for energy-demanding muscle contraction. However, the mitochondria also have a plethora of other functions such as; calcium ion homeostasis, iron-sulphur cluster formation, redox signalling and apoptotic signalling, which are of similarly high importance to skeletal muscle function. As such, it is of little surprise that mitochondrial dysfunction has been linked to a large number of neuromuscular conditions as well as healthy skeletal muscle ageing and sarcopenia. However, the mechanisms by which the dysfunction occurs and its pathological and clinical relevance remains to be understood. This thesis therefore aims to advance the understanding of mechanisms and pathological significance of mitochondrial dysfunction in mitochondrial disease, myofibrillar myopathy, dysferlin myopathy and skeletal muscle ageing. The project was approached from three very different angles. Firstly, by exploring mitochondrial dysfunction in myofibrillar myopathy, dysferlinopathy and looking for potential links to disease pathology. Secondly, by attempting to understand mechanisms and factors effecting clonal expansion of mitochondrial DNA (mtDNA) mutations, which accumulate with age in post mitotic tissues in both healthy individuals and those affected by neuromuscular and neurodegenerative disorders. Both of these approaches were investigated using histochemical, immunocytochemical and single cell genetic methodologies. Finally, possible links between mitochondrial morphology, ultrastructure and function were investigated using electron microscopy techniques. This work provides novel insights into mitochondrial involvement in neuromuscular disease pathology. Key findings include; the reduction of mitochondrial mass in myofibrillar myopathy, increased respiratory chain deficiency in some patients with dysferlinopathy, the spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy, the anisotropic nature of the skeletal muscle mitochondria, the perinuclear origins of mtDNA deletions and their clonal expansion due to retrograde signalling and mitochondrial biogenesis.MRC supplementary award committee at Newcastle University for granting me additional funding to undertake a period of work at Columbia Universit

The Boston University Photonics Center annual report 2014-2015

This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2014-2015 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted $18.6M in new research grants/contracts. Faculty and staff also expanded their efforts in education and training, and were awarded two new National Science Foundation– sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Advanced Materials by Design for the 21st Century at our annual symposium. We continued to support the National Photonics Initiative, and are a part of a New York–based consortium that won the competition for a new photonics- themed node in the National Network of Manufacturing Institutes. Highlights of our research achievements for the year include an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, continued support of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Catherine Klapperich, a new award for Personalized Chemotherapy Through Rapid Monitoring with Wearable Optics led by Assistant Professor Darren Roblyer, and a new award from DARPA to conduct research on Calligraphy to Build Tunable Optical Metamaterials led by Professor Dave Bishop. We were also honored to receive an award from the Massachusetts Life Sciences Center to develop a biophotonics laboratory in our Business Innovation Center

The Boston University Photonics Center annual report 2014-2015

This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2014-2015 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted $18.6M in new research grants/contracts. Faculty and staff also expanded their efforts in education and training, and were awarded two new National Science Foundation– sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Advanced Materials by Design for the 21st Century at our annual symposium. We continued to support the National Photonics Initiative, and are a part of a New York–based consortium that won the competition for a new photonics- themed node in the National Network of Manufacturing Institutes. Highlights of our research achievements for the year include an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, continued support of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Catherine Klapperich, a new award for Personalized Chemotherapy Through Rapid Monitoring with Wearable Optics led by Assistant Professor Darren Roblyer, and a new award from DARPA to conduct research on Calligraphy to Build Tunable Optical Metamaterials led by Professor Dave Bishop. We were also honored to receive an award from the Massachusetts Life Sciences Center to develop a biophotonics laboratory in our Business Innovation Center

Spartan Daily, December 13, 1971

Volume 59, Issue 48https://scholarworks.sjsu.edu/spartandaily/5462/thumbnail.jp

Community Pride Reporter, 10/1996

https://digitalcommons.usm.maine.edu/cpr/1036/thumbnail.jp