Workplace Surfaces as Resource for Social Interactions

Space and spatial arrangements play an important role in our everyday social interactions. The way we use and manage our surrounding space is not coincidental, on the contrary, it reflects the way we think, plan and act. Within collaborative contexts, its ability to support social activities makes space an important component of human cognition in the post-cognitive era. As technology designers, we can learn a lot by rigorously understanding the role of space for the purpose of designing collaborative systems. In this paper, we describe an ethnographic study on the use of workplace surfaces in design studios. We introduce the idea of artful surfaces. Artful surfaces are full of informative, inspirational and creative artefacts that help designers accomplish their everyday design practices. The way these surfaces are created and used could provide information about how designers work. Using examples from our fieldwork, we show that artful surfaces have both functional and inspirational characteristics. We indentify four types of artful surfaces: personal, shared, project-specific and live surfaces. We believe that a greater insight into how these artful surfaces are created and used could lead to better design of novel display technologies to support designers' everyday work

Test results of a prototype designed to detect horizontal cosmic ray flux

In this paper we report test results from a prototype designed to detect muons from horizontal air shower at large zenith angle, $86^{0}<\Theta<93^{0}$. To detect horizontal tracks and their directions we select them according the muon vertical equivalent charge and we measure the time of flight with a time resolution of 800 ps. Several measurements are collected at different zenith angles. The background studies performed with two modules show that the main source is due to tracks crossing the module at the same time. The upper limit of background flux for a single twin module is estimated to be $10^{-9} cm^{-2}$ $s^{-1}$ $sr^{-1} (90$. We estimated the size of the surface array necessary to detect the shower flux of the order of $10^{-9} cm^{-2}$ $yr^{-1}$ $sr^{-1}$ if originated by Tau Air-Showers secondaries of GZK neutrino Tau below the horizons.Comment: 12 pages, 13 figure

Alignment apparatus using a laser having a gravitationally sensitive cavity reflector

A description is given of a device for determining a true gravitational vertical. The apparatus is composed of a vertically disposed laser with a gravitationally sensitive lower regeneration reflector. The reflector enables an output beam to be developed only when the optical axis of the laser is disposed normal to the gravitationally sensitive reflective surface. In an alternative embodiment, the devices is combined with a servo system to provide a gravitationally stabilized horizontal platform

Rapid simultaneous identification and quantitation of Staphylococcus aureus and Pseudomonas aeruginosa directly from bronchoalveolar lavage specimens using automated microscopy

AbstractDiagnosis of ventilator-assisted pneumonia (VAP) requires pathogen quantitation of respiratory samples. Current quantitative culture methods require overnight growth, and pathogen identification requires an additional step. Automated microscopy can perform rapid simultaneous identification and quantitation of live, surface-immobilized bacteria extracted directly from patient specimens using image data collected over 3 h. Automated microscopy was compared to 1 μL loop culture and standard identification methods for Staphylococcus aureus and Pseudomonas spp. in 53 remnant bronchoalveolar lavage specimens. Microscopy identified 9/9 S. aureus and 7/7 P. aeruginosa in all specimens with content above the VAP diagnostic threshold. Concordance for specimens containing targets above the diagnostic threshold was 13/16, with concordance for sub-diagnostic content of 86/90. Results demonstrated that automated microscopy had higher precision than 1 μL loop culture (range ~0.55 log versus ≥1 log), with a dynamic range of ~4 logs (~103 to 106 CFU/mL)

Lightweight reflector assembly

An inexpensive, lightweight reflective assembly member having good optical quality and particularly adaptable to accommodating temperature variations without providing destructive thermal stresses and reflective slope errors is described. The reflective assembly consists of a thin sheet of glass with appropriate reflective coating and a cellular glass block substrate bonded together. The method of fabrication includes abrading the cellular substrate with an abrasive master die to form an appropriate concave surface. An adhesive is applied to the abraded surface and a lamina reflective surface is placed under a uniform pressure to conform the reflective surface onto the desired abraded surface of the substrate

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.

Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear. Here we report that syntaxin 3 is involved in orchestrating polarized trafficking in cultured rat hippocampal neurons. We show that syntaxin 3 localizes to the axonal plasma membrane, particularly to axonal tips, whereas syntaxin 4 localizes to the somatodendritic plasma membrane. Disruption of a conserved N-terminal targeting motif, which causes mislocalization of syntaxin 3, results in coincident mistargeting of the axonal cargos neuron-glia cell adhesion molecule (NgCAM) and neurexin, but not transferrin receptor, a somatodendritic cargo. Similarly, RNAi-mediated knockdown of endogenous syntaxin 3 leads to partial mistargeting of NgCAM, demonstrating that syntaxin 3 plays an important role in its targeting. Additionally, overexpression of syntaxin 3 results in increased axonal growth. Our findings suggest an important role for syntaxin 3 in maintaining neuronal polarity and in the critical task of selective trafficking of membrane protein to axons