Spectral Generalized Multi-Dimensional Scaling

Multidimensional scaling (MDS) is a family of methods that embed a given set of points into a simple, usually flat, domain. The points are assumed to be sampled from some metric space, and the mapping attempts to preserve the distances between each pair of points in the set. Distances in the target space can be computed analytically in this setting. Generalized MDS is an extension that allows mapping one metric space into another, that is, multidimensional scaling into target spaces in which distances are evaluated numerically rather than analytically. Here, we propose an efficient approach for computing such mappings between surfaces based on their natural spectral decomposition, where the surfaces are treated as sampled metric-spaces. The resulting spectral-GMDS procedure enables efficient embedding by implicitly incorporating smoothness of the mapping into the problem, thereby substantially reducing the complexity involved in its solution while practically overcoming its non-convex nature. The method is compared to existing techniques that compute dense correspondence between shapes. Numerical experiments of the proposed method demonstrate its efficiency and accuracy compared to state-of-the-art approaches

On central tendency and dispersion measures for intervals and hypercubes

The uncertainty or the variability of the data may be treated by considering, rather than a single value for each data, the interval of values in which it may fall. This paper studies the derivation of basic description statistics for interval-valued datasets. We propose a geometrical approach in the determination of summary statistics (central tendency and dispersion measures) for interval-valued variables

Automated Segmentation of Cells with IHC Membrane Staining

This study presents a fully automated membrane segmentation technique for immunohistochemical tissue images with membrane staining, which is a critical task in computerized immunohistochemistry (IHC). Membrane segmentation is particularly tricky in immunohistochemical tissue images because the cellular membranes are visible only in the stained tracts of the cell, while the unstained tracts are not visible. Our automated method provides accurate segmentation of the cellular membranes in the stained tracts and reconstructs the approximate location of the unstained tracts using nuclear membranes as a spatial reference. Accurate cell-by-cell membrane segmentation allows per cell morphological analysis and quantification of the target membrane proteins that is fundamental in several medical applications such as cancer characterization and classification, personalized therapy design, and for any other applications requiring cell morphology characterization. Experimental results on real datasets from different anatomical locations demonstrate the wide applicability and high accuracy of our approach in the context of IHC analysi

On the optimality of shape and data representation in the spectral domain

A proof of the optimality of the eigenfunctions of the Laplace-Beltrami operator (LBO) in representing smooth functions on surfaces is provided and adapted to the field of applied shape and data analysis. It is based on the Courant-Fischer min-max principle adapted to our case. % The theorem we present supports the new trend in geometry processing of treating geometric structures by using their projection onto the leading eigenfunctions of the decomposition of the LBO. Utilisation of this result can be used for constructing numerically efficient algorithms to process shapes in their spectrum. We review a couple of applications as possible practical usage cases of the proposed optimality criteria. % We refer to a scale invariant metric, which is also invariant to bending of the manifold. This novel pseudo-metric allows constructing an LBO by which a scale invariant eigenspace on the surface is defined. We demonstrate the efficiency of an intermediate metric, defined as an interpolation between the scale invariant and the regular one, in representing geometric structures while capturing both coarse and fine details. Next, we review a numerical acceleration technique for classical scaling, a member of a family of flattening methods known as multidimensional scaling (MDS). There, the optimality is exploited to efficiently approximate all geodesic distances between pairs of points on a given surface, and thereby match and compare between almost isometric surfaces. Finally, we revisit the classical principal component analysis (PCA) definition by coupling its variational form with a Dirichlet energy on the data manifold. By pairing the PCA with the LBO we can handle cases that go beyond the scope defined by the observation set that is handled by regular PCA

Edge Potential Functions (EPF) and Genetic Algorithms (GA) for Edge-Based Matching of Visual Objects

Edges are known to be a semantically rich representation of the contents of a digital image. Nevertheless, their use in practical applications is sometimes limited by computation and complexity constraints. In this paper, a new approach is presented that addresses the problem of matching visual objects in digital images by combining the concept of Edge Potential Functions (EPF) with a powerful matching tool based on Genetic Algorithms (GA). EPFs can be easily calculated starting from an edge map and provide a kind of attractive pattern for a matching contour, which is conveniently exploited by GAs. Several tests were performed in the framework of different image matching applications. The results achieved clearly outline the potential of the proposed method as compared to state of the art methodologies. (c) 2007 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works