4,446 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Knowledge-based Biomedical Data Science 2019
Knowledge-based biomedical data science (KBDS) involves the design and
implementation of computer systems that act as if they knew about biomedicine.
Such systems depend on formally represented knowledge in computer systems,
often in the form of knowledge graphs. Here we survey the progress in the last
year in systems that use formally represented knowledge to address data science
problems in both clinical and biological domains, as well as on approaches for
creating knowledge graphs. Major themes include the relationships between
knowledge graphs and machine learning, the use of natural language processing,
and the expansion of knowledge-based approaches to novel domains, such as
Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages
with 3 table
Kernelized Hashcode Representations for Relation Extraction
Kernel methods have produced state-of-the-art results for a number of NLP
tasks such as relation extraction, but suffer from poor scalability due to the
high cost of computing kernel similarities between natural language structures.
A recently proposed technique, kernelized locality-sensitive hashing (KLSH),
can significantly reduce the computational cost, but is only applicable to
classifiers operating on kNN graphs. Here we propose to use random subspaces of
KLSH codes for efficiently constructing an explicit representation of NLP
structures suitable for general classification methods. Further, we propose an
approach for optimizing the KLSH model for classification problems by
maximizing an approximation of mutual information between the KLSH codes
(feature vectors) and the class labels. We evaluate the proposed approach on
biomedical relation extraction datasets, and observe significant and robust
improvements in accuracy w.r.t. state-of-the-art classifiers, along with
drastic (orders-of-magnitude) speedup compared to conventional kernel methods.Comment: To appear in the proceedings of conference, AAAI-1
Node Embedding over Temporal Graphs
In this work, we present a method for node embedding in temporal graphs. We
propose an algorithm that learns the evolution of a temporal graph's nodes and
edges over time and incorporates this dynamics in a temporal node embedding
framework for different graph prediction tasks. We present a joint loss
function that creates a temporal embedding of a node by learning to combine its
historical temporal embeddings, such that it optimizes per given task (e.g.,
link prediction). The algorithm is initialized using static node embeddings,
which are then aligned over the representations of a node at different time
points, and eventually adapted for the given task in a joint optimization. We
evaluate the effectiveness of our approach over a variety of temporal graphs
for the two fundamental tasks of temporal link prediction and multi-label node
classification, comparing to competitive baselines and algorithmic
alternatives. Our algorithm shows performance improvements across many of the
datasets and baselines and is found particularly effective for graphs that are
less cohesive, with a lower clustering coefficient
Deep Learning for Genomics: A Concise Overview
Advancements in genomic research such as high-throughput sequencing
techniques have driven modern genomic studies into "big data" disciplines. This
data explosion is constantly challenging conventional methods used in genomics.
In parallel with the urgent demand for robust algorithms, deep learning has
succeeded in a variety of fields such as vision, speech, and text processing.
Yet genomics entails unique challenges to deep learning since we are expecting
from deep learning a superhuman intelligence that explores beyond our knowledge
to interpret the genome. A powerful deep learning model should rely on
insightful utilization of task-specific knowledge. In this paper, we briefly
discuss the strengths of different deep learning models from a genomic
perspective so as to fit each particular task with a proper deep architecture,
and remark on practical considerations of developing modern deep learning
architectures for genomics. We also provide a concise review of deep learning
applications in various aspects of genomic research, as well as pointing out
potential opportunities and obstacles for future genomics applications.Comment: Invited chapter for Springer Book: Handbook of Deep Learning
Application
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