29,530 research outputs found
6G White Paper on Machine Learning in Wireless Communication Networks
The focus of this white paper is on machine learning (ML) in wireless
communications. 6G wireless communication networks will be the backbone of the
digital transformation of societies by providing ubiquitous, reliable, and
near-instant wireless connectivity for humans and machines. Recent advances in
ML research has led enable a wide range of novel technologies such as
self-driving vehicles and voice assistants. Such innovation is possible as a
result of the availability of advanced ML models, large datasets, and high
computational power. On the other hand, the ever-increasing demand for
connectivity will require a lot of innovation in 6G wireless networks, and ML
tools will play a major role in solving problems in the wireless domain. In
this paper, we provide an overview of the vision of how ML will impact the
wireless communication systems. We first give an overview of the ML methods
that have the highest potential to be used in wireless networks. Then, we
discuss the problems that can be solved by using ML in various layers of the
network such as the physical layer, medium access layer, and application layer.
Zero-touch optimization of wireless networks using ML is another interesting
aspect that is discussed in this paper. Finally, at the end of each section,
important research questions that the section aims to answer are presented
Machine learning applied to enzyme turnover numbers reveals protein structural correlates and improves metabolic models.
Knowing the catalytic turnover numbers of enzymes is essential for understanding the growth rate, proteome composition, and physiology of organisms, but experimental data on enzyme turnover numbers is sparse and noisy. Here, we demonstrate that machine learning can successfully predict catalytic turnover numbers in Escherichia coli based on integrated data on enzyme biochemistry, protein structure, and network context. We identify a diverse set of features that are consistently predictive for both in vivo and in vitro enzyme turnover rates, revealing novel protein structural correlates of catalytic turnover. We use our predictions to parameterize two mechanistic genome-scale modelling frameworks for proteome-limited metabolism, leading to significantly higher accuracy in the prediction of quantitative proteome data than previous approaches. The presented machine learning models thus provide a valuable tool for understanding metabolism and the proteome at the genome scale, and elucidate structural, biochemical, and network properties that underlie enzyme kinetics
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