16,453 research outputs found
Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery
The electrocardiogram or ECG has been in use for over 100 years and remains
the most widely performed diagnostic test to characterize cardiac structure and
electrical activity. We hypothesized that parallel advances in computing power,
innovations in machine learning algorithms, and availability of large-scale
digitized ECG data would enable extending the utility of the ECG beyond its
current limitations, while at the same time preserving interpretability, which
is fundamental to medical decision-making. We identified 36,186 ECGs from the
UCSF database that were 1) in normal sinus rhythm and 2) would enable training
of specific models for estimation of cardiac structure or function or detection
of disease. We derived a novel model for ECG segmentation using convolutional
neural networks (CNN) and Hidden Markov Models (HMM) and evaluated its output
by comparing electrical interval estimates to 141,864 measurements from the
clinical workflow. We built a 725-element patient-level ECG profile using
downsampled segmentation data and trained machine learning models to estimate
left ventricular mass, left atrial volume, mitral annulus e' and to detect and
track four diseases: pulmonary arterial hypertension (PAH), hypertrophic
cardiomyopathy (HCM), cardiac amyloid (CA), and mitral valve prolapse (MVP).
CNN-HMM derived ECG segmentation agreed with clinical estimates, with median
absolute deviations (MAD) as a fraction of observed value of 0.6% for heart
rate and 4% for QT interval. Patient-level ECG profiles enabled quantitative
estimates of left ventricular and mitral annulus e' velocity with good
discrimination in binary classification models of left ventricular hypertrophy
and diastolic function. Models for disease detection ranged from AUROC of 0.94
to 0.77 for MVP. Top-ranked variables for all models included known ECG
characteristics along with novel predictors of these traits/diseases.Comment: 13 pages, 6 figures, 1 Table + Supplemen
Exploiting Prior Knowledge in Compressed Sensing Wireless ECG Systems
Recent results in telecardiology show that compressed sensing (CS) is a
promising tool to lower energy consumption in wireless body area networks for
electrocardiogram (ECG) monitoring. However, the performance of current
CS-based algorithms, in terms of compression rate and reconstruction quality of
the ECG, still falls short of the performance attained by state-of-the-art
wavelet based algorithms. In this paper, we propose to exploit the structure of
the wavelet representation of the ECG signal to boost the performance of
CS-based methods for compression and reconstruction of ECG signals. More
precisely, we incorporate prior information about the wavelet dependencies
across scales into the reconstruction algorithms and exploit the high fraction
of common support of the wavelet coefficients of consecutive ECG segments.
Experimental results utilizing the MIT-BIH Arrhythmia Database show that
significant performance gains, in terms of compression rate and reconstruction
quality, can be obtained by the proposed algorithms compared to current
CS-based methods.Comment: Accepted for publication at IEEE Journal of Biomedical and Health
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A Deep Learning Approach to Examine Ischemic ST Changes in Ambulatory ECG Recordings.
Patients with suspected acute coronary syndrome (ACS) are at risk of transient myocardial ischemia (TMI), which could lead to serious morbidity or even mortality. Early detection of myocardial ischemia can reduce damage to heart tissues and improve patient condition. Significant ST change in the electrocardiogram (ECG) is an important marker for detecting myocardial ischemia during the rule-out phase of potential ACS. However, current ECG monitoring software is vastly underused due to excessive false alarms. The present study aims to tackle this problem by combining a novel image-based approach with deep learning techniques to improve the detection accuracy of significant ST depression change. The obtained convolutional neural network (CNN) model yields an average area under the curve (AUC) at 89.6% from an independent testing set. At selected optimal cutoff thresholds, the proposed model yields a mean sensitivity at 84.4% while maintaining specificity at 84.9%
Biosignal Generation and Latent Variable Analysis with Recurrent Generative Adversarial Networks
The effectiveness of biosignal generation and data augmentation with
biosignal generative models based on generative adversarial networks (GANs),
which are a type of deep learning technique, was demonstrated in our previous
paper. GAN-based generative models only learn the projection between a random
distribution as input data and the distribution of training data.Therefore, the
relationship between input and generated data is unclear, and the
characteristics of the data generated from this model cannot be controlled.
This study proposes a method for generating time-series data based on GANs and
explores their ability to generate biosignals with certain classes and
characteristics. Moreover, in the proposed method, latent variables are
analyzed using canonical correlation analysis (CCA) to represent the
relationship between input and generated data as canonical loadings. Using
these loadings, we can control the characteristics of the data generated by the
proposed method. The influence of class labels on generated data is analyzed by
feeding the data interpolated between two class labels into the generator of
the proposed GANs. The CCA of the latent variables is shown to be an effective
method of controlling the generated data characteristics. We are able to model
the distribution of the time-series data without requiring domain-dependent
knowledge using the proposed method. Furthermore, it is possible to control the
characteristics of these data by analyzing the model trained using the proposed
method. To the best of our knowledge, this work is the first to generate
biosignals using GANs while controlling the characteristics of the generated
data
ESC core curriculum for the general cardiologist (2013)
[No abstract available
Theoretical Interpretations and Applications of Radial Basis Function Networks
Medical applications usually used Radial Basis Function Networks just as Artificial Neural Networks. However, RBFNs are Knowledge-Based Networks that can be interpreted in several way: Artificial Neural Networks, Regularization Networks, Support Vector Machines, Wavelet Networks, Fuzzy Controllers, Kernel Estimators, Instanced-Based Learners. A survey of their interpretations and of their corresponding learning algorithms is provided as well as a brief survey on dynamic learning algorithms. RBFNs' interpretations can suggest applications that are particularly interesting in medical domains
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