Error Corrective Boosting for Learning Fully Convolutional Networks with Limited Data

Training deep fully convolutional neural networks (F-CNNs) for semantic image segmentation requires access to abundant labeled data. While large datasets of unlabeled image data are available in medical applications, access to manually labeled data is very limited. We propose to automatically create auxiliary labels on initially unlabeled data with existing tools and to use them for pre-training. For the subsequent fine-tuning of the network with manually labeled data, we introduce error corrective boosting (ECB), which emphasizes parameter updates on classes with lower accuracy. Furthermore, we introduce SkipDeconv-Net (SD-Net), a new F-CNN architecture for brain segmentation that combines skip connections with the unpooling strategy for upsampling. The SD-Net addresses challenges of severe class imbalance and errors along boundaries. With application to whole-brain MRI T1 scan segmentation, we generate auxiliary labels on a large dataset with FreeSurfer and fine-tune on two datasets with manual annotations. Our results show that the inclusion of auxiliary labels and ECB yields significant improvements. SD-Net segments a 3D scan in 7 secs in comparison to 30 hours for the closest multi-atlas segmentation method, while reaching similar performance. It also outperforms the latest state-of-the-art F-CNN models.Comment: Accepted at MICCAI 201

Learned versus Hand-Designed Feature Representations for 3d Agglomeration

For image recognition and labeling tasks, recent results suggest that machine learning methods that rely on manually specified feature representations may be outperformed by methods that automatically derive feature representations based on the data. Yet for problems that involve analysis of 3d objects, such as mesh segmentation, shape retrieval, or neuron fragment agglomeration, there remains a strong reliance on hand-designed feature descriptors. In this paper, we evaluate a large set of hand-designed 3d feature descriptors alongside features learned from the raw data using both end-to-end and unsupervised learning techniques, in the context of agglomeration of 3d neuron fragments. By combining unsupervised learning techniques with a novel dynamic pooling scheme, we show how pure learning-based methods are for the first time competitive with hand-designed 3d shape descriptors. We investigate data augmentation strategies for dramatically increasing the size of the training set, and show how combining both learned and hand-designed features leads to the highest accuracy

Effective classifiers for detecting objects

Several state-of-the-art machine learning classifiers are compared for the purposes of object detection in complex images, using global image features derived from the Ohta color space and Local Binary Patterns. Image complexity in this sense refers to the degree to which the target objects are occluded and/or non-dominant (i.e. not in the foreground) in the image, and also the degree to which the images are cluttered with non-target objects. The results indicate that a voting ensemble of Support Vector Machines, Random Forests, and Boosted Decision Trees provide the best performance with AUC values of up to 0.92 and Equal Error Rate accuracies of up to 85.7% in stratified 10-fold cross validation experiments on the GRAZ02 complex image dataset

Topological descriptors for 3D surface analysis

We investigate topological descriptors for 3D surface analysis, i.e. the classification of surfaces according to their geometric fine structure. On a dataset of high-resolution 3D surface reconstructions we compute persistence diagrams for a 2D cubical filtration. In the next step we investigate different topological descriptors and measure their ability to discriminate structurally different 3D surface patches. We evaluate their sensitivity to different parameters and compare the performance of the resulting topological descriptors to alternative (non-topological) descriptors. We present a comprehensive evaluation that shows that topological descriptors are (i) robust, (ii) yield state-of-the-art performance for the task of 3D surface analysis and (iii) improve classification performance when combined with non-topological descriptors.Comment: 12 pages, 3 figures, CTIC 201

Statistical methods for tissue array images - algorithmic scoring and co-training

Recent advances in tissue microarray technology have allowed immunohistochemistry to become a powerful medium-to-high throughput analysis tool, particularly for the validation of diagnostic and prognostic biomarkers. However, as study size grows, the manual evaluation of these assays becomes a prohibitive limitation; it vastly reduces throughput and greatly increases variability and expense. We propose an algorithm - Tissue Array Co-Occurrence Matrix Analysis (TACOMA) - for quantifying cellular phenotypes based on textural regularity summarized by local inter-pixel relationships. The algorithm can be easily trained for any staining pattern, is absent of sensitive tuning parameters and has the ability to report salient pixels in an image that contribute to its score. Pathologists' input via informative training patches is an important aspect of the algorithm that allows the training for any specific marker or cell type. With co-training, the error rate of TACOMA can be reduced substantially for a very small training sample (e.g., with size 30). We give theoretical insights into the success of co-training via thinning of the feature set in a high-dimensional setting when there is "sufficient" redundancy among the features. TACOMA is flexible, transparent and provides a scoring process that can be evaluated with clarity and confidence. In a study based on an estrogen receptor (ER) marker, we show that TACOMA is comparable to, or outperforms, pathologists' performance in terms of accuracy and repeatability.Comment: Published in at http://dx.doi.org/10.1214/12-AOAS543 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Improving Patch-Based Convolutional Neural Networks for MRI Brain Tumor Segmentation by Leveraging Location Information.

The manual brain tumor annotation process is time consuming and resource consuming, therefore, an automated and accurate brain tumor segmentation tool is greatly in demand. In this paper, we introduce a novel method to integrate location information with the state-of-the-art patch-based neural networks for brain tumor segmentation. This is motivated by the observation that lesions are not uniformly distributed across different brain parcellation regions and that a locality-sensitive segmentation is likely to obtain better segmentation accuracy. Toward this, we use an existing brain parcellation atlas in the Montreal Neurological Institute (MNI) space and map this atlas to the individual subject data. This mapped atlas in the subject data space is integrated with structural Magnetic Resonance (MR) imaging data, and patch-based neural networks, including 3D U-Net and DeepMedic, are trained to classify the different brain lesions. Multiple state-of-the-art neural networks are trained and integrated with XGBoost fusion in the proposed two-level ensemble method. The first level reduces the uncertainty of the same type of models with different seed initializations, and the second level leverages the advantages of different types of neural network models. The proposed location information fusion method improves the segmentation performance of state-of-the-art networks including 3D U-Net and DeepMedic. Our proposed ensemble also achieves better segmentation performance compared to the state-of-the-art networks in BraTS 2017 and rivals state-of-the-art networks in BraTS 2018. Detailed results are provided on the public multimodal brain tumor segmentation (BraTS) benchmarks

Image Parsing with a Wide Range of Classes and Scene-Level Context

This paper presents a nonparametric scene parsing approach that improves the overall accuracy, as well as the coverage of foreground classes in scene images. We first improve the label likelihood estimates at superpixels by merging likelihood scores from different probabilistic classifiers. This boosts the classification performance and enriches the representation of less-represented classes. Our second contribution consists of incorporating semantic context in the parsing process through global label costs. Our method does not rely on image retrieval sets but rather assigns a global likelihood estimate to each label, which is plugged into the overall energy function. We evaluate our system on two large-scale datasets, SIFTflow and LMSun. We achieve state-of-the-art performance on the SIFTflow dataset and near-record results on LMSun.Comment: Published at CVPR 2015, Computer Vision and Pattern Recognition (CVPR), 2015 IEEE Conference o

ReSeg: A Recurrent Neural Network-based Model for Semantic Segmentation

We propose a structured prediction architecture, which exploits the local generic features extracted by Convolutional Neural Networks and the capacity of Recurrent Neural Networks (RNN) to retrieve distant dependencies. The proposed architecture, called ReSeg, is based on the recently introduced ReNet model for image classification. We modify and extend it to perform the more challenging task of semantic segmentation. Each ReNet layer is composed of four RNN that sweep the image horizontally and vertically in both directions, encoding patches or activations, and providing relevant global information. Moreover, ReNet layers are stacked on top of pre-trained convolutional layers, benefiting from generic local features. Upsampling layers follow ReNet layers to recover the original image resolution in the final predictions. The proposed ReSeg architecture is efficient, flexible and suitable for a variety of semantic segmentation tasks. We evaluate ReSeg on several widely-used semantic segmentation datasets: Weizmann Horse, Oxford Flower, and CamVid; achieving state-of-the-art performance. Results show that ReSeg can act as a suitable architecture for semantic segmentation tasks, and may have further applications in other structured prediction problems. The source code and model hyperparameters are available on https://github.com/fvisin/reseg.Comment: In CVPR Deep Vision Workshop, 201

Text Detection in Natural Scenes and Technical Diagrams with Convolutional Feature Learning and Cascaded Classification

An enormous amount of digital images are being generated and stored every day. Understanding text in these images is an important challenge with large impacts for academic, industrial and domestic applications. Recent studies address the difficulty of separating text targets from noise and background, all of which vary greatly in natural scenes. To tackle this problem, we develop a text detection system to analyze and utilize visual information in a data driven, automatic and intelligent way. The proposed method incorporates features learned from data, including patch-based coarse-to-fine detection (Text-Conv), connected component extraction using region growing, and graph-based word segmentation (Word-Graph). Text-Conv is a sliding window-based detector, with convolution masks learned using the Convolutional k-means algorithm (Coates et. al, 2011). Unlike convolutional neural networks (CNNs), a single vector/layer of convolution mask responses are used to classify patches. An initial coarse detection considers both local and neighboring patch responses, followed by refinement using varying aspect ratios and rotations for a smaller local detection window. Different levels of visual detail from ground truth are utilized in each step, first using constraints on bounding box intersections, and then a combination of bounding box and pixel intersections. Combining masks from different Convolutional k-means initializations, e.g., seeded using random vectors and then support vectors improves performance. The Word-Graph algorithm uses contextual information to improve word segmentation and prune false character detections based on visual features and spatial context. Our system obtains pixel, character, and word detection f-measures of 93.14%, 90.26%, and 86.77% respectively for the ICDAR 2015 Robust Reading Focused Scene Text dataset, out-performing state-of-the-art systems, and producing highly accurate text detection masks at the pixel level. To investigate the utility of our feature learning approach for other image types, we perform tests on 8- bit greyscale USPTO patent drawing diagram images. An ensemble of Ada-Boost classifiers with different convolutional features (MetaBoost) is used to classify patches as text or background. The Tesseract OCR system is used to recognize characters in detected labels and enhance performance. With appropriate pre-processing and post-processing, f-measures of 82% for part label location, and 73% for valid part label locations and strings are obtained, which are the best obtained to-date for the USPTO patent diagram data set used in our experiments. To sum up, an intelligent refinement of convolutional k-means-based feature learning and novel automatic classification methods are proposed for text detection, which obtain state-of-the-art results without the need for strong prior knowledge. Different ground truth representations along with features including edges, color, shape and spatial relationships are used coherently to improve accuracy. Different variations of feature learning are explored, e.g. support vector-seeded clustering and MetaBoost, with results suggesting that increased diversity in learned features benefit convolution-based text detectors