A probabilistic approach for pediatric epilepsy diagnosis using brain functional connectivity networks

BACKGROUND: The lives of half a million children in the United States are severely affected due to the alterations in their functional and mental abilities which epilepsy causes. This study aims to introduce a novel decision support system for the diagnosis of pediatric epilepsy based on scalp EEG data in a clinical environment. METHODS: A new time varying approach for constructing functional connectivity networks (FCNs) of 18 subjects (7 subjects from pediatric control (PC) group and 11 subjects from pediatric epilepsy (PE) group) is implemented by moving a window with overlap to split the EEG signals into a total of 445 multi-channel EEG segments (91 for PC and 354 for PE) and finding the hypothetical functional connectivity strengths among EEG channels. FCNs are then mapped into the form of undirected graphs and subjected to extraction of graph theory based features. An unsupervised labeling technique based on Gaussian mixtures model (GMM) is then used to delineate the pediatric epilepsy group from the control group. RESULTS:The study results show the existence of a statistically significant difference (p \u3c 0.0001) between the mean FCNs of PC and PE groups. The system was able to diagnose pediatric epilepsy subjects with the accuracy of 88.8% with 81.8% sensitivity and 100% specificity purely based on exploration of associations among brain cortical regions and without a priori knowledge of diagnosis. CONCLUSIONS:The current study created the potential of diagnosing epilepsy without need for long EEG recording session and time-consuming visual inspection as conventionally employed

Multiband Spectrum Access: Great Promises for Future Cognitive Radio Networks

Cognitive radio has been widely considered as one of the prominent solutions to tackle the spectrum scarcity. While the majority of existing research has focused on single-band cognitive radio, multiband cognitive radio represents great promises towards implementing efficient cognitive networks compared to single-based networks. Multiband cognitive radio networks (MB-CRNs) are expected to significantly enhance the network's throughput and provide better channel maintenance by reducing handoff frequency. Nevertheless, the wideband front-end and the multiband spectrum access impose a number of challenges yet to overcome. This paper provides an in-depth analysis on the recent advancements in multiband spectrum sensing techniques, their limitations, and possible future directions to improve them. We study cooperative communications for MB-CRNs to tackle a fundamental limit on diversity and sampling. We also investigate several limits and tradeoffs of various design parameters for MB-CRNs. In addition, we explore the key MB-CRNs performance metrics that differ from the conventional metrics used for single-band based networks.Comment: 22 pages, 13 figures; published in the Proceedings of the IEEE Journal, Special Issue on Future Radio Spectrum Access, March 201

Retinal image analysis: Image processing and feature extraction oriented to the clinical task

Medical digital imaging has become a key element of modern health care procedures. It provides visual documentation and a permanent record for the patients, and most important the ability to extract quantitative information about many diseases. Modern ophthalmology relies on the advances in digital imaging and computing power. In this paper we present an overview of the results from the doctoral dissertation by Andrés G. Marrugo. This dissertation contributes to the digital analysis of retinal images and the problems that arise along the imaging pipeline of fundus photography, a field that is commonly referred to as retinal image analysis. We have dealt with and proposed solutions to problems that arise in retinal image acquisition and longitudinal monitoring of retinal disease evolution. Specifically, non-uniform illumination compensation, poor image quality, automated focusing, image segmentation, change detection, space-invariant (SI) and space-variant (SV) blind deconvolution (BD). Digital retinal image analysis can be effective and cost-efficient for disease management, computeraided diagnosis, screening and telemedicine and applicable to a variety of disorders such as glaucoma, macular degeneration, and retinopathy. © 2017. Sociedad Española de Óptica. All right reserved

Signal Processing Research Program

Contains table of contents for Part III, table of contents for Section 1, an introduction and reports on fourteen research projects.Charles S. Draper Laboratory Contract DL-H-404158U.S. Navy - Office of Naval Research Grant N00014-89-J-1489National Science Foundation Grant MIP 87-14969Battelle LaboratoriesTel-Aviv University, Department of Electronic SystemsU.S. Army Research Office Contract DAAL03-86-D-0001The Federative Republic of Brazil ScholarshipSanders Associates, Inc.Bell Northern Research, Ltd.Amoco Foundation FellowshipGeneral Electric FellowshipNational Science Foundation FellowshipU.S. Air Force - Office of Scientific Research FellowshipU.S. Navy - Office of Naval Research Grant N00014-85-K-0272Natural Science and Engineering Research Council of Canada - Science and Technology Scholarshi

Image processing and machine learning techniques used in computer-aided detection system for mammogram screening - a review

This paper aims to review the previously developed Computer-aided detection (CAD) systems for mammogram screening because increasing death rate in women due to breast cancer is a global medical issue and it can be controlled only by early detection with regular screening. Till now mammography is the widely used breast imaging modality. CAD systems have been adopted by the radiologists to increase the accuracy of the breast cancer diagnosis by avoiding human errors and experience related issues. This study reveals that in spite of the higher accuracy obtained by the earlier proposed CAD systems for breast cancer diagnosis, they are not fully automated. Moreover, the false-positive mammogram screening cases are high in number and over-diagnosis of breast cancer exposes a patient towards harmful overtreatment for which a huge amount of money is being wasted. In addition, it is also reported that the mammogram screening result with and without CAD systems does not have noticeable difference, whereas the undetected cancer cases by CAD system are increasing. Thus, future research is required to improve the performance of CAD system for mammogram screening and make it completely automated

Mitigating Interference with Knowledge-Aided Subarray Pattern Synthesis and Space Time Adaptive Processing

Phased arrays are essential to airborne ground moving target indication (GMTI), as they measure the spatial angle-of-arrival of the target, clutter, and interference signals. The spatial and Doppler (temporal) frequency is utilized by space-time adaptive processing (STAP) to separate and filter out the interference from the moving target returns. Achieving acceptable airborne GMTI performance often requires fairly large arrays, but the size, weight and power (SWAP) requirements, cost and complexity considerations often result in the use of subarrays. This yields an acceptable balance between cost and performance while lowering the system’s robustness to interference. This thesis proposes the use of knowledge aided adaptive radar to institute adaptive subarray nulling in concert with digital space-time adaptive processing to improve performance in the presence of substantial interference. This research expands previous work which analyzed a clutter-free airborne moving-target indication (AMTI) application of knowledge-aided subarray pattern synthesis (KASPS) [1] and updates this previous research by applying the same concept to the GMTI application with clutter and STAP

Adaptive Illumination Patterns for Radar Applications

The fundamental goal of Fully Adaptive Radar (FAR) involves full exploitation of the joint, synergistic adaptivity of the radar\u27s transmitter and receiver. Little work has been done to exploit the joint space time Degrees-of-Freedom (DOF) available via an Active Electronically Steered Array (AESA) during the radar\u27s transmit illumination cycle. This research introduces Adaptive Illumination Patterns (AIP) as a means for exploiting this previously untapped transmit DOF. This research investigates ways to mitigate clutter interference effects by adapting the illumination pattern on transmit. Two types of illumination pattern adaptivity were explored, termed Space Time Illumination Patterns (STIP) and Scene Adaptive Illumination Patterns (SAIP). Using clairvoyant knowledge, STIP demonstrates the ability to remove sidelobe clutter at user specified Doppler frequencies, resulting in optimum receiver performance using a non-adaptive receive processor. Using available database knowledge, SAIP demonstrated the ability to reduce training data heterogeneity in dense target environments, thereby greatly improving the minimum discernable velocity achieved through STAP processing