3D optimal perturbations developing in homogeneous mixing layers in presence of subharmonic vortex-pairing

Many experimental and numerical studies have found that the pairing of primary Klevin-Helmholtz (KH) vortices in mixing layers generally inhibits the growth of infinintesimal three-dimensional disturbances, delaying the transition to turbulence. In this work, we investigate the existence of 3D perturbations that grow fast enough to survive the subharmonic merging instability. For this purpose, we perform a numerical study of the transient linear evolution of 3D perturbations emerging in a homogeneous time-evolving mixing layer which undergoes pairing. We look at the optimal perturbation that yields the largest gain of energy at a specific time horizon, by use of an optimization method which solves iteratively the linearized direct and adjoint Navier-Stokes equations. In particular, we consider the influence of the time horizon relative to the saturation time of both the primary KH and subharmonic pairing instabilities

Thermal dissociation of dipositronium: path integral Monte Carlo approach

Path integral Monte Carlo simulation of the dipositronium "molecule" Ps$_2$ reveals its surprising thermal instability. Although, the binding energy is $\sim 0.4$ eV, due to the strong temperature dependence of its free energy Ps$_2$ dissociates, or does not form, above $\sim 1000$ K, except for high densities where a small fraction of molecules are in equilibrium with Ps atoms. This prediction is consistent with the recently reported first observation of stable Ps$_2$ molecules by Cassidy & Mills Jr., Nature {\bf 449}, 195 (07), and Phys.Rev.Lett. {\bf 100}, 013401 (08); at temperatures below 1000 K. The relatively sharp transition from molecular to atomic equilibrium, that we find, remains to be experimentally verified. To shed light on the origin of the large entropy factor in free energy we analyze the nature of interatomic interactions of these strongly correlated quantum particles. The conventional diatomic potential curve is given by the van der Waals interaction at large distances, but due to the correlations and high delocalization of constituent particles the concept of potential curve becomes ambiguous at short atomic distances.Comment: Submitted to the Physical Review Letter

Software Engineers' Information Seeking Behavior in Change Impact Analysis - An Interview Study

Software engineers working in large projects must navigate complex information landscapes. Change Impact Analysis (CIA) is a task that relies on engineers' successful information seeking in databases storing, e.g., source code, requirements, design descriptions, and test case specifications. Several previous approaches to support information seeking are task-specific, thus understanding engineers' seeking behavior in specific tasks is fundamental. We present an industrial case study on how engineers seek information in CIA, with a particular focus on traceability and development artifacts that are not source code. We show that engineers have different information seeking behavior, and that some do not consider traceability particularly useful when conducting CIA. Furthermore, we observe a tendency for engineers to prefer less rigid types of support rather than formal approaches, i.e., engineers value support that allows flexibility in how to practically conduct CIA. Finally, due to diverse information seeking behavior, we argue that future CIA support should embrace individual preferences to identify change impact by empowering several seeking alternatives, including searching, browsing, and tracing.Comment: Accepted for publication in the proceedings of the 25th International Conference on Program Comprehensio

A mechanistic first--passage time framework for bacterial cell-division timing

How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells on average, add a fixed size (volume) from birth to division. Interestingly, this added volume differs considerably among genetically-identical newborn cells with similar sizes suggesting a stochastic component in the timing of cell-division. To mechanistically explain the adder principle, we consider a time-keeper protein that begins to get stochastically expressed after cell birth at a rate proportional to the volume. Cell-division time is formulated as the first-passage time for protein copy numbers to hit a fixed threshold. Consistent with data, the model predicts that while the mean cell-division time decreases with increasing size of newborns, the noise in timing increases with size at birth. Intriguingly, our results show that the distribution of the volume added between successive cell-division events is independent of the newborn cell size. This was dramatically seen in experimental studies, where histograms of the added volume corresponding to different newborn sizes collapsed on top of each other. The model provides further insights consistent with experimental observations: the distributions of the added volume and the cell-division time when scaled by their respective means become invariant of the growth rate. Finally, we discuss various modifications to the proposed model that lead to deviations from the adder principle. In summary, our simple yet elegant model explains key experimental findings and suggests a mechanism for regulating both the mean and fluctuations in cell-division timing for size control

A review of job-exposure matrix methodology for application to workers exposed to radiation from internally deposited plutonium or other radioactive materials

Any potential health effects of radiation emitted from radionuclides deposited in the bodies of workers exposed to radioactive materials can be directly investigated through epidemiological studies. However, estimates of radionuclide exposure and consequent tissue-specific doses, particularly for early workers for whom monitoring was relatively crude but exposures tended to be highest, can be uncertain, limiting the accuracy of risk estimates. We review the use of job-exposure matrices (JEMs) in peer-reviewed epidemiological and exposure assessment studies of nuclear industry workers exposed to radioactive materials as a method for addressing gaps in exposure data, and discuss methodology and comparability between studies. We identified nine studies of nuclear worker cohorts in France, Russia, the USA and the UK that had incorporated JEMs in their exposure assessments. All these JEMs were study or cohort-specific, and although broadly comparable methodologies were used in their construction, this is insufficient to enable the transfer of any one JEM to another study. Moreover there was often inadequate detail on whether, or how, JEMs were validated. JEMs have become more detailed and more quantitative, and this trend may eventually enable better comparison across, and the pooling of, studies. We conclude that JEMs have been shown to be a valuable exposure assessment methodology for imputation of missing exposure data for nuclear worker cohorts with data not missing at random. The next step forward for direct comparison or pooled analysis of complete cohorts would be the use of transparent and transferable methods

Are U.S. Exports Different from China's Exports? Evidence from Japan's Imports

Are U.S. exports different from China's exports? If so, how? This paper attempts to answer this question, focusing on the quality, variety, and overlap of their products. Using product-level manufacturing import data from Japan, I find that the exports of China and the United States are similar in terms of variety. More than 85 percent of U.S. export products to Japan are commonly exported from China. However, U.S. exports are different from China's exports in terms of quality. A comparison with the European Union (EU) shows that U.S. exports are similar to EU exports in terms of both quality and variety when compared to Chinaàs exports. These results suggest that quality matters. Both the EU and the United States are better endowed with the factors needed to produce quality or are relatively more productive in producing quality products than China.China, America, trade, exports

Private Provision of Highways: Economic Issues

This paper reviews issues raised by the use of private firms to finance, build, and/or operate highways — issues including cost of capital, level and structure of tolls, and adaptability to unforeseen changes. The public sector’s apparent advantage in cost of capital is at least partly illusory due to differences in tax liability and to constraints on the supply of public capital. The evidence for lower costs of construction or operation by private firms is slim. Private firms are likely to promote more efficient pricing. Effective private road provision depends on well-structured franchise agreements that allow pricing flexibility, restrain market power, enforce a sound debt structure, promote transparency, and foster other social goals.Privatization; Road finance; Toll road; Road pricing

On the Connection Between Metal Absorbers and Quasar Nebulae

We establish a simple model for the distribution of cold gas around L* galaxies using a large set of observational constraints on the properties of strong MgII absorber systems. Our analysis suggests that the halos of L* galaxies are filled with cool gaseous clouds having sizes of order 1kpc and densities of ~10^{-2} cm^{-3}. We then investigate the physical effects of cloud irradiation by a quasar and study the resulting spectral signatures. We show that quasar activity gives rise to (i) extended narrow-line emission on ~100kpc scales and (ii) an anisotropy in the properties of the absorbing gas arising from the geometry of the quasar radiation field. Provided that quasars reside in halos several times more massive than those of L* galaxies, our model predictions appear to be in agreement with observations of narrow emission-line nebulae around quasars and the recent detections of ~100kpc cold gaseous envelopes around those objects, suggesting a common origin for these phenomena. We discuss the implications of our results for understanding absorption systems, probing quasar environments at high redshifts, and testing the quasar unification scheme.Comment: 15 pages, 13 figures (ApJ submitted