Ideating Mobile Health Behavioral Support for Compliance to Therapy for Patients with Chronic Disease: A Case Study of Atrial Fibrillation Management

Poor patient compliance to therapy results in a worsening condition that often increases healthcare costs. In the MobiGuide project, we developed an evidence-based clinical decision-support system that delivered personalized reminders and recommendations to patients, helping to achieve higher therapy compliance. Yet compliance could still be improved and therefore building on the MobiGuide project experience, we designed a new component called the Motivational Patient Assistant (MPA) that is integrated within the MobiGuide architecture to further improve compliance. This component draws from psychological theories to provide behavioral support to improve patient engagement and thereby increasing patients\u27 compliance. Behavior modification interventions are delivered via mobile technology at patients\u27 home environments. Our approach was inspired by the IDEAS (Integrate, Design, Assess, and Share) framework for developing effective digital interventions to change health behavior; it goes beyond this approach by extending the Ideation phase\u27 concepts into concrete backend architectural components and graphical user-interface designs that implement behavioral interventions. We describe in detail our ideation approach and how it was applied to design the user interface of MPA for anticoagulation therapy for the atrial fibrillation patients. We report results of a preliminary evaluation involving patients and care providers that shows the potential usefulness of the MPA for improving compliance to anticoagulation therapy

Thermal barrier coating life modeling in aircraft gas turbine engines

Analytical models useful for predicting ceramic thermal barrier coating (TBC) spalling life in aircraft gas turbine engines are presented. Electron beam-physical vapor deposited (EB-PVD) and plasma sprayed TBC systems are discussed. TBC spalling was attributed to a combination of mechanisms such as metal oxidation at the ceramic-metal interface, ceramic-metal interface stress concentrations at free surfaces due to dissimilar materials, ceramic-metal interface stresses caused by local radius of curvature and interface roughness, material properties and mechanical behavior, transient temperature gradients across the ceramic layer and component design features. TBC spalling life analytical models were developed based on observations of TBC failure modes and plausible failure theories. TBC failure was assumed to occur when the imposed stresses exceeded the material strength (at or near the ceramic-metal interface). TBC failure knowledge gaps caused by lack of experimental evidence and analytical understanding are noted. The analytical models are considered initial engineering approaches that capture observed TBC failure trends

Scaling Up Automated Verification: A Case Study and a Formalization IDE for Building High Integrity Software

Component-based software verification is a difficult challenge because developers must specify components formally and annotate implementations with suitable assertions that are amenable to automation. This research investigates the intrinsic complexity in this challenge using a component-based case study. Simultaneously, this work also seeks to minimize the extrinsic complexities of this challenge through the development and usage of a formalization integrated development environment (F-IDE) built for specifying, developing, and using verified reusable software components. The first contribution is an F-IDE built to support formal specification and automated verification of object-based software for the integrated specification and programming language RESOLVE. The F-IDE is novel, as it integrates a verifying compiler with a user-friendly interface that provides a number of amenities including responsive editing for model-based mathematical contracts and code, assistance for design by contract, verification, responsive error handling, and generation of property-preserving Java code that can be run within the F-IDE. The second contribution is a case study built using the F-IDE that involves an interplay of multiple artifacts encompassing mathematical units, component interfaces, and realizations. The object-based interfaces involved are specified in terms of new mathematical models and non-trivial theories designed to encapsulate data structures and algorithms. The components are designed to be amenable to modular verification and analysis

A Few Considerations on Structural and Logical Composition in Specification Theories

Over the last 20 years a large number of automata-based specification theories have been proposed for modeling of discrete,real-time and probabilistic systems. We have observed a lot of shared algebraic structure between these formalisms. In this short abstract, we collect results of our work in progress on describing and systematizing the algebraic assumptions in specification theories.Comment: In Proceedings FIT 2010, arXiv:1101.426

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic)

Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation. It presents: a brief view of the uncertainty classification: Aleatory uncertainty comes from the inherent uncertain nature and phenomena, and epistemic uncertainty comes from the lack of knowledge, a formulation of the tolerance analysis problem based on this classification, its development: Aleatory uncertainty is modeled by probability distributions while epistemic uncertainty is modeled by intervals; Monte Carlo simulation is employed for probabilistic analysis while nonlinear optimization is used for interval analysis.“AHTOLA” project (ANR-11- MONU-013

Modal Interface Automata

De Alfaro and Henzinger's Interface Automata (IA) and Nyman et al.'s recent combination IOMTS of IA and Larsen's Modal Transition Systems (MTS) are established frameworks for specifying interfaces of system components. However, neither IA nor IOMTS consider conjunction that is needed in practice when a component shall satisfy multiple interfaces, while Larsen's MTS-conjunction is not closed and Bene\v{s} et al.'s conjunction on disjunctive MTS does not treat internal transitions. In addition, IOMTS-parallel composition exhibits a compositionality defect. This article defines conjunction (and also disjunction) on IA and disjunctive MTS and proves the operators to be 'correct', i.e., the greatest lower bounds (least upper bounds) wrt. IA- and resp. MTS-refinement. As its main contribution, a novel interface theory called Modal Interface Automata (MIA) is introduced: MIA is a rich subset of IOMTS featuring explicit output-must-transitions while input-transitions are always allowed implicitly, is equipped with compositional parallel, conjunction and disjunction operators, and allows a simpler embedding of IA than Nyman's. Thus, it fixes the shortcomings of related work, without restricting designers to deterministic interfaces as Raclet et al.'s modal interface theory does.Comment: 28 page