Hybrid modeling, HMM/NN architectures, and protein applications

We describe a hybrid modeling approach where the parameters of a model are calculated and modulated by another model, typically a neural network (NN), to avoid both overfitting and underfitting. We develop the approach for the case of Hidden Markov Models (HMMs), by deriving a class of hybrid HMM/NN architectures. These architectures can be trained with unified algorithms that blend HMM dynamic programming with NN backpropagation. In the case of complex data, mixtures of HMMs or modulated HMMs must be used. NNs can then be applied both to the parameters of each single HMM, and to the switching or modulation of the models, as a function of input or context. Hybrid HMM/NN architectures provide a flexible NN parameterization for the control of model structure and complexity. At the same time, they can capture distributions that, in practice, are inaccessible to single HMMs. The HMM/NN hybrid approach is tested, in its simplest form, by constructing a model of the immunoglobulin protein family. A hybrid model is trained, and a multiple alignment derived, with less than a fourth of the number of parameters used with previous single HMMs

Diffusion of Context and Credit Information in Markovian Models

This paper studies the problem of ergodicity of transition probability matrices in Markovian models, such as hidden Markov models (HMMs), and how it makes very difficult the task of learning to represent long-term context for sequential data. This phenomenon hurts the forward propagation of long-term context information, as well as learning a hidden state representation to represent long-term context, which depends on propagating credit information backwards in time. Using results from Markov chain theory, we show that this problem of diffusion of context and credit is reduced when the transition probabilities approach 0 or 1, i.e., the transition probability matrices are sparse and the model essentially deterministic. The results found in this paper apply to learning approaches based on continuous optimization, such as gradient descent and the Baum-Welch algorithm.Comment: See http://www.jair.org/ for any accompanying file

3D medical volume segmentation using hybrid multiresolution statistical approaches

This article is available through the Brunel Open Access Publishing Fund. Copyright © 2010 S AlZu’bi and A Amira.3D volume segmentation is the process of partitioning voxels into 3D regions (subvolumes) that represent meaningful physical entities which are more meaningful and easier to analyze and usable in future applications. Multiresolution Analysis (MRA) enables the preservation of an image according to certain levels of resolution or blurring. Because of multiresolution quality, wavelets have been deployed in image compression, denoising, and classification. This paper focuses on the implementation of efficient medical volume segmentation techniques. Multiresolution analysis including 3D wavelet and ridgelet has been used for feature extraction which can be modeled using Hidden Markov Models (HMMs) to segment the volume slices. A comparison study has been carried out to evaluate 2D and 3D techniques which reveals that 3D methodologies can accurately detect the Region Of Interest (ROI). Automatic segmentation has been achieved using HMMs where the ROI is detected accurately but suffers a long computation time for its calculations

Joint Multi-Pitch Detection Using Harmonic Envelope Estimation for Polyphonic Music Transcription

In this paper, a method for automatic transcription of music signals based on joint multiple-F0 estimation is proposed. As a time-frequency representation, the constant-Q resonator time-frequency image is employed, while a novel noise suppression technique based on pink noise assumption is applied in a preprocessing step. In the multiple-F0 estimation stage, the optimal tuning and inharmonicity parameters are computed and a salience function is proposed in order to select pitch candidates. For each pitch candidate combination, an overlapping partial treatment procedure is used, which is based on a novel spectral envelope estimation procedure for the log-frequency domain, in order to compute the harmonic envelope of candidate pitches. In order to select the optimal pitch combination for each time frame, a score function is proposed which combines spectral and temporal characteristics of the candidate pitches and also aims to suppress harmonic errors. For postprocessing, hidden Markov models (HMMs) and conditional random fields (CRFs) trained on MIDI data are employed, in order to boost transcription accuracy. The system was trained on isolated piano sounds from the MAPS database and was tested on classic and jazz recordings from the RWC database, as well as on recordings from a Disklavier piano. A comparison with several state-of-the-art systems is provided using a variety of error metrics, where encouraging results are indicated