Hardware/Software Co-Design of Ultra-Low Power Biomedical Monitors

Ongoing changes in world demographics and the prevalence of unhealthy lifestyles are imposing a paradigm shift in healthcare delivery. Nowadays, chronic ailments such as cardiovascular diseases, hypertension and diabetes, represent the most common causes of death according to the World Health Organization. It is estimated that 63% of deaths worldwide are directly or indirectly related to these non-communicable diseases (NCDs), and by 2030 it is predicted that the health delivery cost will reach an amount comparable to 75% of the current GDP. In this context, technologies based on Wireless Sensor Nodes (WSNs) effectively alleviate this burden enabling the conception of wearable biomedical monitors composed of one or several devices connected through a Wireless Body Sensor Network (WBSN). Energy efficiency is of paramount importance for these devices, which must operate for prolonged periods of time with a single battery charge. In this thesis I propose a set of hardware/software co-design techniques to drastically increase the energy efficiency of bio-medical monitors. To this end, I jointly explore different alternatives to reduce the required computational effort at the software level while optimizing the power consumption of the processing hardware by employing ultra-low power multi-core architectures that exploit DSP application characteristics. First, at the sensor level, I study the utilization of a heartbeat classifier to perform selective advanced DSP on state-of-the-art ECG bio-medical monitors. To this end, I developed a framework to design and train real-time, lightweight heartbeat neuro-fuzzy classifiers, detail- ing the required optimizations to efficiently execute them on a resource-constrained platform. Then, at the network level I propose a more complex transmission-aware WBSN for activity monitoring that provides different tradeoffs between classification accuracy and transmission volume. In this work, I study the combination of a minimal set of WSNs with a smartphone, and propose two classification schemes that trade accuracy for transmission volume. The proposed method can achieve accuracies ranging from 88% to 97% and can save up to 86% of wireless transmissions, outperforming the state-of-the-art alternatives. Second, I propose a synchronization-based low-power multi-core architecture for bio-signal processing. I introduce a hardware/software synchronization mechanism that allows to achieve high energy efficiency while parallelizing the execution of multi-channel DSP applications. Then, I generalize the methodology to support bio-signal processing applications with an arbitrarily high degree of parallelism. Due to the benefits of SIMD execution and software pipelining, the architecture can reduce its power consumption by up 38% when compared to an equivalent low-power single-core alternative. Finally, I focused on the optimization of the multi-core memory subsystem, which is the major contributor to the overall system power consumption. First I considered a hybrid memory subsystem featuring a small reliable partition that can operate at ultra-low voltage enabling low-power buffering of data and obtaining up to 50% energy savings. Second, I explore a two-level memory hierarchy based on non-volatile memories (NVM) that allows for aggressive fine-grained power gating enabled by emerging low-power NVM technologies and monolithic 3D integration. Experimental results show that, by adopting this memory hierarchy, power consumption can be reduced by 5.42x in the DSP stage

Arquitectura de un sistema integrado para diseño dirigido por modelos en el contexto de internet de las cosas con aplicaciones en medicina

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Informática, Departamento de Arquitectura de Computadores y Automática, leída el 14-10-20222Over the past few years, we have seen how processing and storage architectures become cheaper and more efficient, communication infrastructures become faster and more scalable, and many new ways of interacting with the world around us are being developed. Every day more devices are connected to the network, and the generation of data worldwide is growing exponentially. In this context, the Internet of Things promises to be the new technological revolution, as was the introduction of the network of networks or universal mobile accessibility in tis day...A lo largo de los últimos años hemos visto cómo las arquitecturas de procesamiento y almacenamiento se vuelven más baratas y eficientes, las infraestructuras de comunicación se hacen más rápidas y escalables, y se desarrollan multitud de nuevas formas de interactuar con el mundo que nos rodea. Cada día más dispositivos se conectan a la red, y la generación de datos a nivel mundal está creciendo exponencialmente. En este contexto, el Internet de las cosas promete ser la nueva revolución tecnológica, como en su día lo fue la introducción de la red de redes o la accesibilidad móvil universal...Fac. de InformáticaTRUEunpu

Design for energy-efficient and reliable fog-assisted healthcare IoT systems

Cardiovascular disease and diabetes are two of the most dangerous diseases as they are the leading causes of death in all ages. Unfortunately, they cannot be completely cured with the current knowledge and existing technologies. However, they can be effectively managed by applying methods of continuous health monitoring. Nonetheless, it is difficult to achieve a high quality of healthcare with the current health monitoring systems which often have several limitations such as non-mobility support, energy inefficiency, and an insufficiency of advanced services. Therefore, this thesis presents a Fog computing approach focusing on four main tracks, and proposes it as a solution to the existing limitations. In the first track, the main goal is to introduce Fog computing and Fog services into remote health monitoring systems in order to enhance the quality of healthcare. In the second track, a Fog approach providing mobility support in a real-time health monitoring IoT system is proposed. The handover mechanism run by Fog-assisted smart gateways helps to maintain the connection between sensor nodes and the gateways with a minimized latency. Results show that the handover latency of the proposed Fog approach is 10%-50% less than other state-of-the-art mobility support approaches. In the third track, the designs of four energy-efficient health monitoring IoT systems are discussed and developed. Each energy-efficient system and its sensor nodes are designed to serve a specific purpose such as glucose monitoring, ECG monitoring, or fall detection; with the exception of the fourth system which is an advanced and combined system for simultaneously monitoring many diseases such as diabetes and cardiovascular disease. Results show that these sensor nodes can continuously work, depending on the application, up to 70-155 hours when using a 1000 mAh lithium battery. The fourth track mentioned above, provides a Fog-assisted remote health monitoring IoT system for diabetic patients with cardiovascular disease. Via several proposed algorithms such as QT interval extraction, activity status categorization, and fall detection algorithms, the system can process data and detect abnormalities in real-time. Results show that the proposed system using Fog services is a promising approach for improving the treatment of diabetic patients with cardiovascular disease

Recent Developments in Smart Healthcare

Medicine is undergoing a sector-wide transformation thanks to the advances in computing and networking technologies. Healthcare is changing from reactive and hospital-centered to preventive and personalized, from disease focused to well-being centered. In essence, the healthcare systems, as well as fundamental medicine research, are becoming smarter. We anticipate significant improvements in areas ranging from molecular genomics and proteomics to decision support for healthcare professionals through big data analytics, to support behavior changes through technology-enabled self-management, and social and motivational support. Furthermore, with smart technologies, healthcare delivery could also be made more efficient, higher quality, and lower cost. In this special issue, we received a total 45 submissions and accepted 19 outstanding papers that roughly span across several interesting topics on smart healthcare, including public health, health information technology (Health IT), and smart medicine

A comparison of statistical machine learning methods in heartbeat detection and classification

In health care, patients with heart problems require quick responsiveness in a clinical setting or in the operating theatre. Towards that end, automated classification of heartbeats is vital as some heartbeat irregularities are time consuming to detect. Therefore, analysis of electro-cardiogram (ECG) signals is an active area of research. The methods proposed in the literature depend on the structure of a heartbeat cycle. In this paper, we use interval and amplitude based features together with a few samples from the ECG signal as a feature vector. We studied a variety of classification algorithms focused especially on a type of arrhythmia known as the ventricular ectopic fibrillation (VEB). We compare the performance of the classifiers against algorithms proposed in the literature and make recommendations regarding features, sampling rate, and choice of the classifier to apply in a real-time clinical setting. The extensive study is based on the MIT-BIH arrhythmia database. Our main contribution is the evaluation of existing classifiers over a range sampling rates, recommendation of a detection methodology to employ in a practical setting, and extend the notion of a mixture of experts to a larger class of algorithms

Reliable and secure low energy sensed spectrum communication for time critical cloud computing applications

Reliability and security of data transmission and access are of paramount importance to enhance the dependability of time critical remote monitoring systems (e.g. tele-monitoring patients, surveillance of smart grid components). Potential failures for data transmissions include wireless channel unavailability and delays due to the interruptions. Reliable data transmission demands seamless channel availability with minimum delays in spite of interruptions (e.g. fading, denial-of-service attacks). Secure data transmissions require sensed data to be transmitted over unreliable wireless channels with sucient security using suitable encryption techniques. The transmitted data are stored in secure cloud repositories. Potential failures for data access include unsuccessful user authentications due to mis-management of digital identities and insucient permissions to authorize situation specic data access requests. Reliable and secure data access requires robust user authentication and context-dependent authorization to fulll situation specic data utility needs in cloud repositories. The work herein seeks to enhance the dependability of time critical remote monitoring applications, by reducing these failure conditions which may degrade the reliability and security of data transmission or access. As a result of an extensive literature survey, in order to achieve the above said security and reliability, the following areas have been selected for further investigations. The enhancement of opportunistic transmissions in cognitive radio networks to provide greater channel availability as opposed to xed spectrum allocations in conventional wireless networks. Delay sensitive channel access methods to ensure seamless connectivity in spite of multiple interruptions in cognitive radio networks. Energy ecient encryption and route selection mechanisms to enhance both secure and reliable data transmissions. Trustworthy digital identity management in cloud platforms which can facilitate ecient user authentication to ensure reliable access to the sensed remote monitoring data. Context-aware authorizations to reliably handle the exible situation specic data access requests. Main contributions of this thesis include a novel trust metric to select non-malicious cooperative spectrum sensing users to reliably detect vacant channels, a reliable delaysensitive cognitive radio spectrum hand-o management method for seamless connectivity and an energy-aware physical unclonable function based encryption key size selection method for secure data transmission. Furthermore, a trust based identity provider selection method for user authentications and a reliable context-aware situation specic authorization method are developed for more reliable and secure date access in cloud repositories. In conclusion, these contributions can holistically contribute to mitigate the above mentioned failure conditions to achieve the intended dependability of the timecritical remote monitoring applications