Near-capacity fixed-rate and rateless channel code constructions

Fixed-rate and rateless channel code constructions are designed for satisfying conflicting design tradeoffs, leading to codes that benefit from practical implementations, whilst offering a good bit error ratio (BER) and block error ratio (BLER) performance. More explicitly, two novel low-density parity-check code (LDPC) constructions are proposed; the first construction constitutes a family of quasi-cyclic protograph LDPC codes, which has a Vandermonde-like parity-check matrix (PCM). The second construction constitutes a specific class of protograph LDPC codes, which are termed as multilevel structured (MLS) LDPC codes. These codes possess a PCM construction that allows the coexistence of both pseudo-randomness as well as a structure requiring a reduced memory. More importantly, it is also demonstrated that these benefits accrue without any compromise in the attainable BER/BLER performance. We also present the novel concept of separating multiple users by means of user-specific channel codes, which is referred to as channel code division multiple access (CCDMA), and provide an example based on MLS LDPC codes. In particular, we circumvent the difficulty of having potentially high memory requirements, while ensuring that each user’s bits in the CCDMA system are equally protected. With regards to rateless channel coding, we propose a novel family of codes, which we refer to as reconfigurable rateless codes, that are capable of not only varying their code-rate but also to adaptively modify their encoding/decoding strategy according to the near-instantaneous channel conditions. We demonstrate that the proposed reconfigurable rateless codes are capable of shaping their own degree distribution according to the nearinstantaneous requirements imposed by the channel, but without any explicit channel knowledge at the transmitter. Additionally, a generalised transmit preprocessing aided closed-loop downlink multiple-input multiple-output (MIMO) system is presented, in which both the channel coding components as well as the linear transmit precoder exploit the knowledge of the channel state information (CSI). More explicitly, we embed a rateless code in a MIMO transmit preprocessing scheme, in order to attain near-capacity performance across a wide range of channel signal-to-ratios (SNRs), rather than only at a specific SNR. The performance of our scheme is further enhanced with the aid of a technique, referred to as pilot symbol assisted rateless (PSAR) coding, whereby a predetermined fraction of pilot bits is appropriately interspersed with the original information bits at the channel coding stage, instead of multiplexing pilots at the modulation stage, as in classic pilot symbol assisted modulation (PSAM). We subsequently demonstrate that the PSAR code-aided transmit preprocessing scheme succeeds in gleaning more information from the inserted pilots than the classic PSAM technique, because the pilot bits are not only useful for sounding the channel at the receiver but also beneficial for significantly reducing the computational complexity of the rateless channel decoder

Research and technology highlights of the Lewis Research Center

Highlights of research accomplishments of the Lewis Research Center for fiscal year 1984 are presented. The report is divided into four major sections covering aeronautics, space communications, space technology, and materials and structures. Six articles on energy are included in the space technology section

Radiomics risk modelling using machine learning algorithms for personalised radiation oncology

One major objective in radiation oncology is the personalisation of cancer treatment. The implementation of this concept requires the identification of biomarkers, which precisely predict therapy outcome. Besides molecular characterisation of tumours, a new approach known as radiomics aims to characterise tumours using imaging data. In the context of the presented thesis, radiomics was established at OncoRay to improve the performance of imaging-based risk models. Two software-based frameworks were developed for image feature computation and risk model construction. A novel data-driven approach for the correction of intensity non-uniformity in magnetic resonance imaging data was evolved to improve image quality prior to feature computation. Further, different feature selection methods and machine learning algorithms for time-to-event survival data were evaluated to identify suitable algorithms for radiomics risk modelling. An improved model performance could be demonstrated using computed tomography data, which were acquired during the course of treatment. Subsequently tumour sub-volumes were analysed and it was shown that the tumour rim contains the most relevant prognostic information compared to the corresponding core. The incorporation of such spatial diversity information is a promising way to improve the performance of risk models.:1. Introduction 2. Theoretical background 2.1. Basic physical principles of image modalities 2.1.1. Computed tomography 2.1.2. Magnetic resonance imaging 2.2. Basic principles of survival analyses 2.2.1. Semi-parametric survival models 2.2.2. Full-parametric survival models 2.3. Radiomics risk modelling 2.3.1. Feature computation framework 2.3.2. Risk modelling framework 2.4. Performance assessments 2.5. Feature selection methods and machine learning algorithms 2.5.1. Feature selection methods 2.5.2. Machine learning algorithms 3. A physical correction model for automatic correction of intensity non-uniformity in magnetic resonance imaging 3.1. Intensity non-uniformity correction methods 3.2. Physical correction model 3.2.1. Correction strategy and model definition 3.2.2. Model parameter constraints 3.3. Experiments 3.3.1. Phantom and simulated brain data set 3.3.2. Clinical brain data set 3.3.3. Abdominal data set 3.4. Summary and discussion 4. Comparison of feature selection methods and machine learning algorithms for radiomics time-to-event survival models 4.1. Motivation 4.2. Patient cohort and experimental design 4.2.1. Characteristics of patient cohort 4.2.2. Experimental design 4.3. Results of feature selection methods and machine learning algorithms evaluation 4.4. Summary and discussion 5. Characterisation of tumour phenotype using computed tomography imaging during treatment 5.1. Motivation 5.2. Patient cohort and experimental design 5.2.1. Characteristics of patient cohort 5.2.2. Experimental design 5.3. Results of computed tomography imaging during treatment 5.4. Summary and discussion 6. Tumour phenotype characterisation using tumour sub-volumes 6.1. Motivation 6.2. Patient cohort and experimental design 6.2.1. Characteristics of patient cohorts 6.2.2. Experimental design 6.3. Results of tumour sub-volumes evaluation 6.4. Summary and discussion 7. Summary and further perspectives 8. Zusammenfassun

Aeronautical engineering: A continuing bibliography with indexes (supplement 204)

This bibliography lists 419 reports, articles, and other documents introduced into the NASA scientific and technical information system in August 1986

INTEGRATION OF BIOMEDICAL IMAGING AND TRANSLATIONAL APPROACHES FOR MANAGEMENT OF HEAD AND NECK CANCER

The aim of the clinical component of this work was to determine whether the currently available clinical imaging tools can be integrated with radiotherapy (RT) platforms for monitoring and adaptation of radiation dose, prediction of tumor response and disease outcomes, and characterization of patterns of failure and normal tissue toxicity in head and neck cancer (HNC) patients with potentially curable tumors. In Aim 1, we showed that the currently available clinical imaging modalities can be successfully used to adapt RT dose based-on dynamic tumor response, predict oncologic disease outcomes, characterize RT-induced toxicity, and identify the patterns of disease failure. We used anatomical MRIs for the RT dose adaptation purpose. Our findings showed that after proper standardization of the immobilization and image acquisition techniques, we can achieve high geometric accuracy. These images can then be used to monitor the shrinkage of tumors during RT and optimize the clinical target volumes accordingly. Our results also showed that this MR-guided dose adaptation technique has a dosimetric advantage over the standard of care and was associated with a reduction in normal tissue doses that translated into a reduction of the odds of long-term RT-induced toxicity. In the second aim, we used quantitative MRIs to determine its benefit for prediction of oncologic outcomes and characterization of RT-induced normal tissue toxicity. Our findings showed that delta changes of apparent diffusion coefficient parameters derived from diffusion-weighted images at mid-RT can be used to predict local recurrence and recurrence free-survival. We also showed that Ktrans and Ve vascular parameters derived from dynamic contrast-enhanced MRIs can characterize the mandibular areas of osteoradionecrosis. In the final clinical aim, we used CT images of recurrence and baseline CT planning images to develop a methodology and workflow that involves the application of deformable image registration software as a tool to standardize image co-registration in addition to granular combined geometric- and dosimetric-based failure characterization to correctly attribute sites and causes of locoregional failure. We then successfully applied this methodology to identify the patterns of failure following postoperative and definitive IMRT in HNC patients. Using this methodology, we showed that most recurrences occurred in the central high dose regions for patients treated with definitive IMRT compared with mainly non-central high dose recurrences after postoperative IMRT. We also correlated recurrences with pretreatment FDG-PET and identified that most of the central high dose recurrences originated in an area that would be covered by a 10-mm margin on the volume of 50% of the maximum FDG uptake. In the translational component of this work, we integrated radiomic features derived from pre-RT CT images with whole-genome measurements using TCGA and TCIA data. Our results demonstrated a statistically significant associations between radiomic features characterizing different tumor phenotypes and different genomic features. These findings represent a promising potential towards non-invasively tract genomic changes in the tumor during treatment and use this information to adapt treatment accordingly. In the final project of this dissertation, we developed a high-throughput approach to identify effective systemic agents against aggressive head and neck tumors with poor prognosis like anaplastic thyroid cancer. We successfully identified three candidate drugs and performed extensive in vitro and in vivo validation using orthotopic and PDX models. Among these drugs, HDAC inhibitor and LBH-589 showed the most effective tumor growth inhibition that can be used in future clinical trials

Research reports: 1990 NASA/ASEE Summer Faculty Fellowship Program

Reports on the research projects performed under the NASA/ASEE Summer Faculty Fellowship Program are presented. The program was conducted by The University of Alabama and MSFC during the period from June 4, 1990 through August 10, 1990. Some of the topics covered include: (1) Space Shuttles; (2) Space Station Freedom; (3) information systems; (4) materials and processes; (4) Space Shuttle main engine; (5) aerospace sciences; (6) mathematical models; (7) mission operations; (8) systems analysis and integration; (9) systems control; (10) structures and dynamics; (11) aerospace safety; and (12) remote sensin

Aeronautical Engineering: A continuing bibliography with indexes, supplement 134

This bibliography lists 387 reports, articles, and solar documents introduced into the NASA scientific and technical information system in March 1981

Aeronautical Engineering: A cumulative index to the 1984 issues of the continuing bibliography

This bibliography is a cumulative index to the abstracts contained in NASA SP-7037(171) through NASA SP-7037(182) of Aeronautical Engineering: A Continuing Bibliography. NASA SP-7037 and its supplements have been compiled through the cooperative efforts of the American Institute of Aeronautics and Astronautics (AIAA) and the National Aeronautics and Space Administration (NASA). This cumulative index includes subject, personal author, corporate source, foreign technology, contract, report number, and accession number indexes