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Artificial Intelligence in Radiotherapy Treatment Planning: Present and Future.
Treatment planning is an essential step of the radiotherapy workflow. It has become more sophisticated over the past couple of decades with the help of computer science, enabling planners to design highly complex radiotherapy plans to minimize the normal tissue damage while persevering sufficient tumor control. As a result, treatment planning has become more labor intensive, requiring hours or even days of planner effort to optimize an individual patient case in a trial-and-error fashion. More recently, artificial intelligence has been utilized to automate and improve various aspects of medical science. For radiotherapy treatment planning, many algorithms have been developed to better support planners. These algorithms focus on automating the planning process and/or optimizing dosimetric trade-offs, and they have already made great impact on improving treatment planning efficiency and plan quality consistency. In this review, the smart planning tools in current clinical use are summarized in 3 main categories: automated rule implementation and reasoning, modeling of prior knowledge in clinical practice, and multicriteria optimization. Novel artificial intelligence-based treatment planning applications, such as deep learning-based algorithms and emerging research directions, are also reviewed. Finally, the challenges of artificial intelligence-based treatment planning are discussed for future works
Tree Memory Networks for Modelling Long-term Temporal Dependencies
In the domain of sequence modelling, Recurrent Neural Networks (RNN) have
been capable of achieving impressive results in a variety of application areas
including visual question answering, part-of-speech tagging and machine
translation. However this success in modelling short term dependencies has not
successfully transitioned to application areas such as trajectory prediction,
which require capturing both short term and long term relationships. In this
paper, we propose a Tree Memory Network (TMN) for modelling long term and short
term relationships in sequence-to-sequence mapping problems. The proposed
network architecture is composed of an input module, controller and a memory
module. In contrast to related literature, which models the memory as a
sequence of historical states, we model the memory as a recursive tree
structure. This structure more effectively captures temporal dependencies
across both short term and long term sequences using its hierarchical
structure. We demonstrate the effectiveness and flexibility of the proposed TMN
in two practical problems, aircraft trajectory modelling and pedestrian
trajectory modelling in a surveillance setting, and in both cases we outperform
the current state-of-the-art. Furthermore, we perform an in depth analysis on
the evolution of the memory module content over time and provide visual
evidence on how the proposed TMN is able to map both long term and short term
relationships efficiently via a hierarchical structure
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