Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil

Superparamagnetic iron-oxide nanoparticles can be used in a variety of medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered. Within this work, we will present a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the measurement of mice. The setup is capable of detecting 5 ng of iron in vitro at 2.14 sec acquisition time. In terms of iron concentration we are able to detect 156 {\mu}g/L marking the lowest value that has been reported for an MPI scanner so far. In vivo MPI mouse images of a 512 ng bolus at 21.5 ms acquisition time allow for capturing the flow of an intravenously injected tracer through the heart of a mouse. Since it has been rather difficult to compare detection limits across MPI publications we propose guidelines improving the comparability of future MPI studies.Comment: 15 Pages, 7 Figures, V2: Changed the initials of Author Kannan M Krishnan, added two citations, corrected typo

Neural Face Editing with Intrinsic Image Disentangling

Traditional face editing methods often require a number of sophisticated and task specific algorithms to be applied one after the other --- a process that is tedious, fragile, and computationally intensive. In this paper, we propose an end-to-end generative adversarial network that infers a face-specific disentangled representation of intrinsic face properties, including shape (i.e. normals), albedo, and lighting, and an alpha matte. We show that this network can be trained on "in-the-wild" images by incorporating an in-network physically-based image formation module and appropriate loss functions. Our disentangling latent representation allows for semantically relevant edits, where one aspect of facial appearance can be manipulated while keeping orthogonal properties fixed, and we demonstrate its use for a number of facial editing applications.Comment: CVPR 2017 ora